Pathological alteration of FoxO3a activity promotes idiopathic pulmonary fibrosis fibroblast proliferation on type i collagen matrix

American Journal of Pathology

Volumn 179, Issue 5, 2011, Pages 2420-2430

  Nho, Richard Seonghun ^a   Hergert, Polla ^a   Kahm, Judith ^a   Jessurun, Jose ^a   Henke, Craig ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; PROTEIN KINASE B; PROTEIN P27; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 80055025175     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.07.020     Document Type: Article

References (35)

1. J.H. Ryu, T.V. Colby, and T.E. Hartman Idiopathic pulmonary fibrosis: current concepts Mayo Clin Proc 73 1998 1085 1101
2. M. Gharaee-Kermani, M.R. Gyetko, B. Hu, and S.H. Phan Pharm: new insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy Pharm Res 24 2007 819 841
3. M. Kuzuya, S. Satake, M.A. Ramos, S. Kanda, T. Koike, K. Yoshino, S. Ikeda, and A. Iguchi Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice Exp Cell Res 248 1999 498 508
4. H. Xia, R.S. Nho, J. Kahm, J. Kleidon, and C.A. Henke Fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway J Biol Chem 279 2004 33024 33034
5. R.S. Nho, H. Xia, J. Kahm, J. Kleidon, D. Diebold, and C.A. Henke Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway J Biol Chem 280 2005 26630 26639
6. R.S. Nho, H. Xia, D. Diebold, J. Kahm, J. Kleidon, E. White, and C.A. Henke PTEN regulates fibroblast elimination during collagen matrix contraction J Biol Chem 281 2006 33291 33301
7. H. Xia, R.S. Nho, J. Kahm, J. Kleidon, and C.A. Henke Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway J Biol Chem 279 2004 33024 33034
8. H. Xia, D. Diebold, R. Nho, D. Perlman, J. Kleidon, J. Kahm, S. Avdulov, M. Peterson, J. Nerva, P. Bitterman, and C. Henke Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis J Exp Med 205 2008 1659 1672
9. H. Xia, W. Khalil, J. Kahm, J. Jessurun, J. Kleidon, and C.A. Henke Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis Am J Pathol 176 2010 2626 2637
10. T. Nakao, A.E. Geddis, N.E. Fox, and K. Kaushansky PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1) Cell Cycle 7 2008 257 266
11. Y. Zhao, M. Fei, Y. Wang, M. Lu, C. Cheng, and A. Shen Expression of Foxo3a in non-Hodgkin's lymphomas is correlated with cell cycle inhibitor p27 Eur J Haematol 81 2008 83 93
12. C.J. Li, J.K. Chang, C.H. Chou, G.J. Wang, and M.L. Ho The PI3K/Akt/FOXO3a/p27Kip1 signaling contributes to anti-inflammatory drug-suppressed proliferation of human osteoblasts Biochem Pharmacol 79 2010 926 937
13. D.H. Castrillon, L. Miao, R. Kollipara, J.W. Horner, and R.A. DePinho Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a Science 301 2003 215 218
14. O.R. Mikse, D.C. Blake Jr, N.R. Jones, Y.W. Sun, S. Amin, C.J. Gallagher, P. Lazarus, J. Weisz, and C.R. Herzog FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma Cancer Res 70 2010 6205 6215
15. A. Sunters, S. Fernández de Mattos, M. Stahl, J.J. Brosens, G. Zoumpoulidou, C.A. Saunders, P.J. Coffer, R.H. Medema, R.C. Coombes, and E.W. Lam FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines J Biol Chem 278 2003 49795 49805
16. N. Chapuis, S. Park, L. Leotoing, J. Tamburini, F. Verdier, V. Bardet, A.S. Green, L. Willems, F. Agou, N. Ifrah, F. Dreyfus, G. Bismuth, V. Baud, C. Lacombe, P. Mayeux, and D. Bouscary IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia Blood 116 2010 4240 4250
17. A. Brunet, J. Park, H. Tran, L.S. Hu, B.A. Hemmings, and M.E. Greenberg Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) Mol Cell Biol 21 2001 952 965
18. R.S. Nho, and J. Kahm β1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A J Biol Chem 285 2010 14195 14209
19. W.H. Zheng, S. Kar, and R. Quirion Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells J Biol Chem 275 2000 39152 39158
20. L. Yusuf, X. Zhu, M.G. Kharas, J. Chen, and D.A. Fruman Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors Blood 104 2004 784 787
21. Y.R. Chen, M.T. Liu, Y.T. Chang, C.C. Wu, C.Y. Hu, and J.Y. Chen Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells J Virol 82 2008 8124 8137
22. J. Nakae, V. Barr, and D. Accili Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR EMBO J 19 2000 989 996
23. E.D. Tang, G. Nuez, F.G. Barr, and K.L. Guan Negative regulation of the forkhead transcription factor FKHR by Akt J Biol Chem 274 1999 16741 16746
24. Y.Y. Sanders, T.O. Tollefsbol, B.M. Varisco, and J.S. Hagood Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts Am J Respir Cell Mol Biol 45 2011 16 23
25. O. Leppranta, V. Pulkkinen, K. Koli, R. Vhtalo, K. Salmenkivi, V.L. Kinnula, M. Heikinheimo, and M. Myllrniemi Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis Am J Respir Cell Mol Biol 42 2010 626 632
26. Y.Y. Sanders, A. Pardo, M. Selman, G.J. Nuovo, T.O. Tollefsbol, G.P. Siegal, and J.S. Hagood Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis Am J Respir Cell Mol Biol 39 2008 610 618
27. E.S. White, R.G. Atrasz, B. Hu, S.H. Phan, V. Stambolic, T.W. Mak, C.M. Hogaboam, K.R. Flaherty, F.J. Martinez, C.D. Kontos, and G.B. Toews Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10) Am J Respir Crit Care Med 173 2006 112 121
28. K.L. Tsai, Y.J. Sun, C.Y. Huang, J.Y. Yang, M.C. Hung, and C.D. Hsiao Crystal structure of the human FoxO3a-DBD/DNA complex suggests the effects of post-translational modification Nucleic Acids Res 35 2007 6984 6994
29. P.W. Noble Idiopathic pulmonary fibrosis: natural history and prognosis Clin Chest Med 27 2006 S11 S16
30. B. Crestani, S. Marchand-Adam, A. Fabre, M. Dehoux, and P. Soler [Mechanisms in pulmonary fibrosis] Rev Prat 57 2007 2222 2226
31. A. Brunet, A. Bonni, M.Z. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 1999 857 868
32. W.H. Biggs 3rd, J. Meisenhelder, T. Hunter, W.K. Cavenee, and K.C. Arden Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 Proc Natl Acad Sci U S A 96 1999 7421 7426
33. J. Ikeda, S. Mamat, T. Tian, Y. Wang, N. Rahadiani, K. Aozasa, and E. Morii Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines Am J Pathol 177 2010 3081 3088
34. S. Shukla, M. Shukla, G.T. Maclennan, P. Fu, and S. Gupta Deregulation of FOXO3A during prostate cancer progression Int J Oncol 34 2009 1613 1620
35. M. Kato, H. Yuan, Z.G. Xu, L. Lanting, S.L. Li, M. Wang, M.C. Hu, M.A. Reddy, and R. Natarajan Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease J Am Soc Nephrol 17 2006 3325 3335