Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics

Biological Psychiatry

Volumn 75, Issue 10, 2014, Pages 765-773

  Lee, Changhoon ^a   Mayfield, R Dayne ^a   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Alcoholism; exon intron expression; GABAB receptor; human prefrontal cortex; RNA Seq; splice junction

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL; GAMMA AMINOBUTYRIC ACID TYPE B RECEPTOR SUBTYPE 1; MICRORNA; SPACER DNA; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID B RECEPTOR; GABA TYPE B RECEPTOR, SUBUNIT 1; ISOPROTEIN; PROTEIN SUBUNIT;

ALCOHOLISM; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE LIBRARY; GENE MAPPING; HUMAN; INTRON; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA SEQUENCE; RNA SPLICING; SIGNAL TRANSDUCTION; ADULT; AGED; BRAIN; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; PROTEIN SUBUNIT;

ADULT; AGED; ALCOHOLISM; BRAIN; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN ISOFORMS; PROTEIN SUBUNITS; RECEPTORS, GABA-B; RNA SPLICING;

EID: 84899624664     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.08.028     Document Type: Article

References (44)

1. J.R. Bradford, Y. Hey, T. Yates, Y. Li, S.D. Pepper, and C.J. Miller A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling BMC Genomics 11 2010 282
2. P. Schweitzer, M. Roberto, S.G. Madamba, and G.R. Siggins Gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors J Pharmacol Exp Ther 311 2004 172 179
3. M. Cammalleri, A. Brancucci, F. Berton, A. Loche, G.L. Gessa, and W. Francesconi Gamma-hydroxybutyrate reduces GABA(A)-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus Neuropsychopharmacology 27 2002 960 969
4. M. Enserink Addiction research. Anonymous alcoholic bankrolls trial of controversial therapy Science 332 2011 653
5. T. Flatscher-Bader, M. van der Brug, J.W. Hwang, P.A. Gochee, I. Matsumoto, S. Niwa, and P.A. Wilce Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics J Neurochem 93 2005 359 370
6. J. Liu, J.M. Lewohl, R.A. Harris, V.R. Iyer, P.R. Dodd, P.K. Randall, and R.D. Mayfield Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals Neuropsychopharmacology 31 2006 1574 1582
7. C. Lee, R.D. Mayfield, and R.A. Harris Intron 4 containing novel GABAB1 isoforms impair GABAB receptor function PLoS One 5 2010 e14044
8. J.Y. Tiao, A. Bradaia, B. Biermann, K. Kaupmann, M. Metz, and C. Haller et al. The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function J Biol Chem 283 2008 31005 31011
9. D.A. Schwarz, G. Barry, S.D. Eliasof, R.E. Petroski, P.J. Conlon, and R.A. Maki Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor J Biol Chem 275 2000 32174 32181
10. S. Isomoto, M. Kaibara, Y. Sakurai-Yamashita, Y. Nagayama, Y. Uezono, K. Yano, and K. Taniyama Cloning and tissue distribution of novel splice variants of the rat GABAB receptor Biochem Biophys Res Commun 253 1998 10 15
11. S.J. Glatt, O.S. Cohen, S.V. Faraone, and M.T. Tsuang Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders Am J Med Genet B Neuropsychiatr Genet 156B 2011 382 392
12. T. Sander, D. Ball, R. Murray, J. Patel, J. Samochowiec, and G. Winterer et al. Association analysis of sequence variants of GABA(A) alpha6, beta2, and gamma2 gene cluster and alcohol dependence Alcohol Clin Exp Res 23 1999 427 431
13. E.S. Barrie, R.M. Smith, J.C. Sanford, and W. Sadee mRNA transcript diversity creates new opportunities for pharmacological intervention Mol Pharmacol 81 2012 620 630
14. P.A. Hardy, W. Chen, and P.A. Wilce Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex Brain Res 819 1999 33 39
15. H.J. Walter, T. McMahon, J. Dadgar, D. Wang, and R.O. Messing Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms J Biol Chem 275 2000 25717 25722
16. G.L. McVey, K.S. Walker, J. Beyers, H.L. Harrison, S.W. Simkins, and S. Russell-Mayhew Integrating weight bias awareness and mental health promotion into obesity prevention delivery: A public health pilot study Prev Chronic Dis 10 2013 E46
17. I. Ponomarev, S. Wang, L. Zhang, R.A. Harris, and R.D. Mayfield Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence J Neurosci 32 2012 1884 1897
18. Y.Y. Zhu, E.M. Machleder, A. Chenchik, R. Li, and P.D. Siebert Reverse transcriptase template switching: A SMART approach for full-length cDNA library construction Biotechniques 30 2001 892 897
19. C. Lee, R.A. Harris, J.K. Wall, R.D. Mayfield, and C.O. Wilke RNaseIII and T4 polynucleotide kinase sequence biases and solutions during RNA-seq library construction Biol Direct 8 2013 16
20. C. Trapnell, L. Pachter, and S.L. Salzberg TopHat: Discovering splice junctions with RNA-Seq Bioinformatics 25 2009 1105 1111
21. L. Wang, Z. Feng, X. Wang, and X. Zhang DEGseq: An R package for identifying differentially expressed genes from RNA-seq data Bioinformatics 26 2010 136 138
22. N. Cloonan, A.R. Forrest, G. Kolle, B.B. Gardiner, G.J. Faulkner, and M.K. Brown et al. Stem cell transcriptome profiling via massive-scale mRNA sequencing Nat Methods 5 2008 613 619
23. K.D. Hansen, S.E. Brenner, and S. Dudoit Biases in Illumina transcriptome sequencing caused by random hexamer priming Nucleic Acids Res 38 2010 e131
24. O.K. Yoon, and R.B. Brem Noncanonical transcript forms in yeast and their regulation during environmental stress RNA 16 2010 1256 1267
25. J.B. Li, E.Y. Levanon, J.K. Yoon, J. Aach, B. Xie, and E. Leproust et al. Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing Science 324 2009 1210 1213
26. Z. Wang, M. Gerstein, and M. Snyder RNA-Seq: A revolutionary tool for transcriptomics Nat Rev Genet 10 2009 57 63
27. J.K. Pickrell, A.A. Pai, Y. Gilad, and J.K. Pritchard Noisy splicing drives mRNA isoform diversity in human cells PLoS Genet 6 2010 e1001236
28. M.T. Dimon, K. Sorber, and J.L. DeRisi HMMSplicer: A tool for efficient and sensitive discovery of known and novel splice junctions in RNA-Seq data PLoS One 5 2010 e13875
29. A. Mortazavi, B.A. Williams, K. McCue, L. Schaeffer, and B. Wold Mapping and quantifying mammalian transcriptomes by RNA-Seq Nat Methods 5 2008 621 628
30. K. Sorber, M.T. Dimon, and J.L. DeRisi RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts Nucleic Acids Res 39 2011 3820 3835
31. E. Bulanova, V. Budagian, E. Duitman, Z. Orinska, H. Krause, and R. Ruckert et al. Soluble interleukin IL-15 ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15 J Biol Chem 282 2007 13167 13179
32. S. Ezzat, L. Zheng, S. Yu, and S.L. Asa A soluble dominant negative fibroblast growth factor receptor 4 isoform in human MCF-7 breast cancer cells Biochem Biophys Res Commun 287 2001 60 65
33. B. Mosley, M.P. Beckmann, C.J. March, R.L. Idzerda, S.D. Gimpel, and T. VandenBos et al. The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms Cell 59 1989 335 348
34. T.J. Bell, K.Y. Miyashiro, J.Y. Sul, R. McCullough, P.T. Buckley, and J. Jochems et al. Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons Proc Natl Acad Sci U S A 105 2008 1901 1906
35. D.J. Jang, S.W. Park, J.A. Lee, C. Lee, Y.S. Chae, and H. Park et al. N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes Learn Mem 17 2010 469 479
36. T.J. Bell, K.Y. Miyashiro, J.Y. Sul, P.T. Buckley, M.T. Lee, and R. McCullough et al. Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations Proc Natl Acad Sci U S A 107 2010 21152 21157
37. E.O. Gracheva, J.F. Cordero-Morales, J.A. Gonzalez-Carcacia, N.T. Ingolia, C. Manno, and C.I. Aranguren et al. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats Nature 476 2011 88 91
38. M.A. Enoch, Z. Zhou, M. Kimura, D.C. Mash, Q. Yuan, and D. Goldman GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naive P and NP rats PLoS One 7 2012 e29369
39. A. Couve, S.J. Moss, and M.N. Pangalos GABAB receptors: A new paradigm in G protein signaling Mol Cell Neurosci 16 2000 296 312
40. M. Roberto, N.W. Gilpin, L.E. O'Dell, M.T. Cruz, A.C. Morse, G.R. Siggins, and G.F. Koob Cellular and behavioral interactions of gabapentin with alcohol dependence J Neurosci 28 2008 5762 5771
41. D. Piomelli Cannabinoid activity curtails cocaine craving Nat Med 7 2001 1099 1100
42. C.P. O'Brien, and E.L. Gardner Critical assessment of how to study addiction and its treatment: Human and non-human animal models Pharmacol Ther 108 2005 18 58
43. L.M. Saba, B. Bennett, P.L. Hoffman, K. Barcomb, T. Ishii, K. Kechris, and B. Tabakoff A systems genetic analysis of alcohol drinking by mice, rats and men: Influence of brain GABAergic transmission Neuropharmacology 60 2011 1269 1280
44. J.C. Garbutt, A.B. Kampov-Polevoy, R. Gallop, L. Kalka-Juhl, and B.A. Flannery Efficacy and safety of baclofen for alcohol dependence: A randomized, double-blind, placebo-controlled trial Alcohol Clin Exp Res 34 2010 1849 1857