Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats

Planta Medica

Volumn 78, Issue 7, 2012, Pages 651-657

  Chaudhari, Hemantkumar Somabhai ^a   Bhandari, Uma ^a   Khanna, Geetika ^b  

^a HAMDARD UNIVERSITY   (India)

^b SAFDARJUNG HOSPITAL   (India)

Author keywords

Embelia ribes Burm.; embelin; hyperlipidemia; Myrsinaceae; obesity; oxidative stress

Indexed keywords

APOLIPOPROTEIN B; CATALASE; EMBELIN; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SUPEROXIDE DISMUTASE; TETRAHYDROLIPSTATIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EMBELIA RIBES; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INTRAABDOMINAL FAT; LIPID DIET; LIPID METABOLISM; LIPID PEROXIDATION; LIVER FATTY DEGENERATION; LIVER HISTOLOGY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OBESITY; OXIDATIVE STRESS; RAT; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; WEIGHT GAIN;

EMBELIA RIBES; MYRSINACEAE; RATTUS; RATTUS NORVEGICUS;

EID: 84930486742     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298379     Document Type: Article

References (35)

1. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. Geneva World Health Organization Headquarters 1997
2. Slim R M., Toborek M, Watkins B A., Boissonneault G A., Hennig B. Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats. J Am Coll Nutr 1996 15 289-294 (Pubitemid 26170864)
3. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and impact on metabolic syndrome. J Clin Invest 2004 114 1752-1761 (Pubitemid 40385531)
4. Hamilton M. Strategies for the management of patients with obesity. Treat Endocrinol 2002 1 21-36 (Pubitemid 36828437)
5. Wu T, Gao X, Chen M, van Dam R M. Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis. Obes Rev 2009 10 313-323
6. Raskin I, Ribnicky D M., Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno D A., Ripoll C, Yakoby N, O'Neal J M., Cornwell T, Pastor I, Fridlender B. Plants and human health in the twenty-first century. Trends Biotechnol 2002 20 522-531 (Pubitemid 35356407)
7. Gupta O P., Ali M M., Ray Ghatak B J., Atal C K. Some pharmacological investigations of embelin and its semisynthetic derivatives. Indian J Physiol Pharmacol 1977 21 31-39 (Pubitemid 8082311)
8. Mahendran S, Maithili V, Badami S. Evaluation of antidiabetic effect of embelin from Embelia ribes in alloxan induced diabetes in rats. Biomed Pharmacother advance online publication 21 09 2010
9. Bhandari U, Kanojia R, Pillai K K. Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats. Int J Exp Diab Res 2002 3 159-162 (Pubitemid 35331372)
10. Bhandari U, Jain N, Pillai K K. Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes. Exp Diabetes Res 2007 2007 1-6
11. Bhandari U, Jain N, Ansari M N., Pillai K K. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia 2008 79 351-355
12. Pawloski C M., Kanagy N L., Mortensen L H., Fink G D. Obese Zucker rats are normotensive on normal and increased sodium intake. Hypertension 1992 19 190-195
13. Pathan R A., Bhandari U. Preparation & characterization of embelin-phospholipid complex as effective drug delivery tool. J Incl Phenom Macrocycl Chem 2011 69 139-147
14. Thippeswamy B S., Nagakannan P, Shivasharan B D., Mahendran S, Veerapur V P., Badami S. Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats. Neurotox Res 2011 20 379-386
15. Thippeswamy B S., Mahendran S, Biradar M I., Raj P, Srivastava K, Badami S, Veerapur V P. Protective effect of embelin against acetic acid induced ulcerative colitis in rats. Eur J Pharmacol 2011 654 100-105
16. Novelli E L. B., Diniz Y S., Galhardi C M., Ebaid G M. X., Rodrigues H G., Mani F, Fernandes A A. H., Cicogna A C., Novelli Filho J L. V. B. Anthropometrical parameters and markers of obesity in rats. Lab Anim 2007 41 111-119 (Pubitemid 46174434)
17. Friedewald W T., Levy R I., Fredrickson D S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972 18 499-502
18. Dobiasova M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FERHDL). Clin Biochem 2001 34 583-588 (Pubitemid 34014853)
19. Alladi S, Shanmugasundaram K R. Induction of hypercholesterolaemia by supplementing soy protein with acetate generating amino-acids. Nutr Rep Int 1989 40 893-899
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid. Anal Biochem 1979 95 359-364
21. Calberg I, Mannerviek B. Glutathione reductase levels in rat brain. J Biol Chem 1975 250 5475-5480
22. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974 47 469-474
23. Caliborne A L. Assay of catalase. In: Greenwald R A. editor Handbook of methods of oxygen radical research. Baco Raton, London (UK) CRC Press 1985 283-285
24. Rizvi F, Iftikhar M, George J P. Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant rats. J Med Food 2003 6 123-128 (Pubitemid 37128473)
25. Kennett G A., Clifton P G. New approaches to the pharmacological treatment of obesity: can they break through the efficacy barrier? Pharmacol Biochem Behav 2010 97 63-83
26. Knight S F., Imig J D. Obesity, insulin resistance, and renal function. Microcirculation 2007 14 349-362 (Pubitemid 47050027)
27. MacMahon S, Cutler J, Brittain E, Higgins M. Obesity and hypertension: epidemiological and clinical issues. Eur Heart J 1987 8 57-70 (Pubitemid 17091714)
28. Brown J L., Spicer M T., Spicer L J. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Endocrine 2002 19 327-332 (Pubitemid 36250314)
29. Mertens I L., Van Gaal L F. Overweight, obesity, and blood pressure: the effects of modest weight reduction. Obes Res 2000 8 270-278
30. Liu C H., Hung M T., Huang P C. Source of triacylglycerol accumulation in lives of rats fed a cholesterol-supplemented diet. Lipids 1995 30 527-531
31. Staiger H, Haring H U. Adipocytokines: fat-derived humoral mediators of metabolic homeostasis. Exp Clin Endocrinol Diabetes 2005 113 67-79 (Pubitemid 40388776)
32. Matsubara M, Chiba H, Maruoka S, Katayose S. Elevated serum leptin concentrations in women with components of multiple risk factor clustering syndrome. J Atheroscler Thromb 2000 7 231-237
33. Hasty H A., Gruen M L., Terry E S., Surmi B K., Atkinson R D., Gao L, Morrow J D. Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model. J Nutr Biochem 2007 18 127-133 (Pubitemid 46048989)
34. Vincent H K., Innes K E., Vincent K R. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007 9 813-839 (Pubitemid 47555204)
35. Ansari J A., Bhandari U, Haque S E., Pillai K K. Enhancement of antioxidant defense mechanism by pitavastatin and rosuvastatin on obesity-induced oxidative stress in Wistar rats. Toxicol Mech Methods advance online publication 23 08 2011