Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists

Journal of Medicinal Chemistry

Volumn 57, Issue 8, 2014, Pages 3450-3463

  Xiao, Jingbo ^a   Free, R Benjamin ^b   Barnaeva, Elena ^a   Conroy, Jennie L ^b   Doyle, Trevor ^b   Miller, Brittney ^b   Bryant Genevier, Marthe ^a   Taylor, Mercedes K ^a   Hu, Xin ^a   Dulcey, Andrés E ^a   Southall, Noel ^a   Ferrer, Marc ^a   Titus, Steve ^a   Zheng, Wei ^a   Sibley, David R ^b   Marugan, Juan J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZEPINE DERIVATIVE; BENZYL DERIVATIVE; BETA ARRESTIN; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; EMBRYO; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

DOPAMINE ANTAGONISTS; DRUG DISCOVERY; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899565433     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500126s     Document Type: Article

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