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Volumn 8, Issue 9, 2006, Pages 1771-1773

Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IRON;

EID: 33646450274     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0600234     Document Type: Article
Times cited : (86)

References (20)
  • 9
    • 33646457146 scopus 로고    scopus 로고
    • note
    • For synthesis, see Supporting Information.
  • 15
    • 33646447006 scopus 로고    scopus 로고
    • 11-(4-Piperidyl)dibenzodiazepines. US4045445, 1977
    • The dibenzodiazepine clozapine analogue 11 has been specifically exemplified and claimed in the patent literature together with some other close piperidyl clozapine analogues. Although a generic synthetic methodology was described (the final step was a condensation reaction giving the imine functionality using phosphorus pentoxide in phosphorus oxychloride at reflux overnight), no physical data supporting the claimed structure 11 was presented. Hardy, R. A., Jr. 11-(4-Piperidyl)dibenzodiazepines. US4045445, 1977.
    • Hardy Jr., R.A.1
  • 17
    • 33646446403 scopus 로고    scopus 로고
    • note
    • Only 0.95 equiv of Grignard reagent was used because of the competing demethoxylation reaction. The use of 2 equiv of Grignard reagent gave 18 in 66% yield.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.