Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions

Journal of Neuroscience

Volumn 20, Issue 22, 2000, Pages 8305-8314

  Wang, Y ^a   Xu, R ^a   Sasaoka, T ^a   Tonegawa, S ^a   Kung, M P ^a   Sankoorikal, E B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autoreceptor; Catalepsy; D2S receptor; Dopamine D2L receptor; Haloperidol; Knock out mice; Locomotion

Indexed keywords

AUTORECEPTOR; DOPAMINE 2 RECEPTOR; HALOPERIDOL; NEUROLEPTIC AGENT; QUINPIROLE;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; LOCOMOTION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SCHIZOPHRENIA;

EID: 0034668907     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-22-08305.2000     Document Type: Article

References (61)

1. Dopamine autoreceptors' pharmacological characterization by microiontophoretic single cell recording studies
2. Parkinson-like locomotor impairment in mice lacking dopamine D2 receptors
3. Mutant mice and neuroscience: Recommendations concerning genetic background
4. Differential coupling of rat D2 dopamine receptor isoforms expressed in Spodoptera frugiperda insect cells
5. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: Comparison with dopamine D2 receptor mRNA
6. Dopaminergic neurons: Effect of antipsychotic drugs and amphetamine on single cell activity
7. Cloning and expression of a rat D2 dopamine receptor cDNA
8. Interactions between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease
9. A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus
10. Molecular diversity of the dopamine receptors
11. The dopamine D2 receptor: Two molecular forms generated by alternative splicing
12. Biphasic effect of D2 agonist quinpirole on locomotion and movements
13. Sulpiride antagonizes the biphasic locomotor effects of quinpirole in weanling rats
14. Alternative splicing directs the expression of two D2 dopamine receptor isoforms
15. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons. 1. Identification and characterization
16. The basal ganglia
17. The basal ganglia and adaptive motor control
18. Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins
19. Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability
20. Metabolism of brain dopamine in human parkinsonism: Neurochemical and clinical aspects
21. Dopamine receptors and brain function
22. Dopamine and schizophrenia - A cortically corrective perspective
23. The quantitative measurement of motor incoordination in naive mice using an accelerating Rota-rod
24. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
25. Locomotor activity in D2 dopamine receptor deficient mice is determined by gene dosage, genetic background, and developmental adaptations
26. Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice
27. Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin
28. Neuroscience of addiction
29. 125I]R(+)trans-7-OH-PIPAT in rat brain
30. Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta
31. The mouse dopamine D2A receptor gene: Sequence homology with the rat and human genes and expression of alternative transcripts
32. Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice
33. Multiple D2 dopamine receptors produced by alternative RNA splicing
34. Molecular and cellular basis of addiction
35. Increased abundance of alternatively spliced forms of D2 dopamine receptor mRNA after denervation
36. Site directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling
37. The ring test: A quantitative method for assessing the 'cataleptic' effect of cannabis in mice
38. Dopamine D2 receptors in signal transduction and behavior
39. The actions of antipsychotic drugs on dopamine receptors in the rat substantia nigra
40. Electrophysiological properties of mouse dopamine neurons: In vivo and in vitro studies
41. Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors
42. The D2 dopamine receptor isoforms signal through distinct G(iα) proteins to inhibit adenylyl cyclase
43. Behavioural and pharmacological characterization of the elevated 'zero-maze' as an animal model of anxiety
44. Molecular neurobiology of dopaminergic receptors
45. Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II mutant mice
46. Catecholamines in the brain as mediators of amphetamine psychosis
47. Changes in reliability of synaptic function as a mechanism for plasticity
48. Alteration of cataleptic responses induced by dopamine receptor antagonists after chronic cocaine administration in mice
49. 125I]S(-)5-OH-PIPAT binding to dopamine D2-like receptors expressed in cell lines
50. 125I]S(-)5-OH-PIPAT
51. 3H]spiperone label equivalent numbers of D2 and D3 dopamine receptors in a range of tissues and under different conditions
52. Excitation of locus coeruleus neurons by an adenosine 3',5' cyclic monophosphate-activated inward current: Extracellular and intracellular studies in rat brain slices
53. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: Evidence fcr a G-protein mediated inward current
54. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: Role of cAMP and protein kinase A
55. Pharmacological characterization of dopamine autoreceptors in the rat ventral tegmental area: Microiontophoretic studies
56. Dopamine autoreceptors
57. Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine mediated behavioral responses
58. 3H]-QN B binding sites in the spinal dorsal horn
59. Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary
60. Tolerance of hypothalamic β endorphin neurons to μ-opioid receptor activation following chronic morphine treatment