Dextran-protamine coated nanostructured lipid carriers as mucus-penetrating nanoparticles for lipophilic drugs

International Journal of Pharmaceutics

Volumn 468, Issue 1-2, 2014, Pages 105-111

  Beloqui, Ana ^a   Solinís, María Ángeles ^a   Rieux, Anne Des ^b   Préat, Véronique ^b   Rodríguez Gascón, Alicia ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Caco 2; HT29 MTX; Mucus; NLCs; Permeability; Saquinavir

Indexed keywords

DEXTRAN; DRUG CARRIER; LIPID; NANOPARTICLE; PROTAMINE; SAQUINAVIR; SURFACTANT; NANOMATERIAL;

ARTICLE; CELL SURFACE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; INTESTINE CELL; INTESTINE MUCOSA; MUCUS; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE CHARGE; CACO 2 CELL LINE; CHEMISTRY; COMPARATIVE STUDY; HT 29 CELL LINE; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; NANOTECHNOLOGY; PERMEABILITY; PHARMACEUTICS; PROCEDURES; SURFACE PROPERTY;

CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; DEXTRANS; DRUG CARRIERS; ENTEROCYTES; HT29 CELLS; HUMANS; INTESTINAL ABSORPTION; MUCUS; NANOSTRUCTURES; NANOTECHNOLOGY; PARTICLE SIZE; PERMEABILITY; PROTAMINES; SAQUINAVIR; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84899561000     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.04.027     Document Type: Article

References (36)

1. V. Albert, P. Modamio, C.F. Lastra, and E.L. Mariño Determination of saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography and the analytical error function Journal of Pharmaceutical and Biomedical Analysis 36 2004 835 840 (Pubitemid 39469424)
2. I. Behrens, A.I. Pena, M.J. Alonso, and T. Kissel Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport Pharmaceutical Research 19 2002 1185 1193 (Pubitemid 34985003)
3. A. Beloqui, M.A. Solinís, A. Delgado, C. Evora, A. del Pozo-Rodríguez, and A. Rodríguez-Gascón Biodistribution of nanostructured lipid carriers (NLCs) after intravenous administration to rats: influence of technological factors European Journal of Pharmaceutics and Biopharmaceutics 84 2013 309 314
4. A. Beloqui, M.A. Solinís, A.R. Gascón, A. del Pozo-Rodríguez, A. des Rieux, and V. Préat Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier Journal of Controlled Release 166 2013 115 123
5. A. Beloqui, M.A. Solinís, A. Delgado, C. Évora, A. Isla, and A. Rodríguez-Gascón Fate of Nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution Journal of Microencapsulation 31 2014 1 8
6. R.A. Cone Barrier properties of mucus Advanced Drug Delivery Reviews 61 2009 75 85
7. P. Couvreur Nanoparticles in drug delivery: past, present and future Advanced Drug Delivery Reviews 65 2013 21 23
8. D. Delgado, A. del Pozo-Rodríguez, M.A. Solinís, and A. Rodríguez-Gascón Understanding the mechanism of protamine in solid lipid nanoparticle-based lipofection: the importance of the entry pathway European Journal of Pharmaceutics and Biopharmaceutics 79 2011 495 502
9. D. Delgado, A.R. Gascón, A. Del Pozo-Rodríguez, E. Echevarría, A.P. Ruiz de Garibay, J.M. Rodríguez, and M.A. Solinís Dextran-protamine-solid lipid nanoparticles as a non-viral vector for gene therapy: in vitro characterization and in vivo transfection after intravenous administration to mice International Journal of Pharmaceutics 425 2012 35 43
10. D. Delgado, A. del Pozo-Rodríguez, M.A. Solinís, M. Avilés-Triqueros, B.H. Weber, E. Fernández, and A.R. Gascón Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis Human Gene Therapy 23 2012 345 355
11. A. des Rieux, E.G.E. Ragnarsson, E. Gullberg, V. Préat, Y.-J. Schneider, and P. Artursson Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium European Journal of Pharmaceutical Sciences 25 2005 455 465 (Pubitemid 40853873)
12. A. des Rieux, V. Pourcelle, P.D. Cani, J. Marchand-Brynaert, and V. Préat Targeted nanoparticles with novel non-peptidic ligands for oral delivery Advanced Drug Delivery Reviews 65 2013 833 844
13. S. Dufort, L. Sancey, and J.L. Coll Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution Advanced Drug Delivery Reviews 64 2012 179 189
14. A. Elgart, I. Cherniakov, Y. Aldouby, A.J. Domb, and A. Hoffman Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds Chemistry and Physics of Lipids 165 2012 438 453
15. L.M. Ensign, R. Cone, and J. Hanes Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers Advanced Drug Delivery Reviews 64 2012 557 570
16. J.M. Gamboa, and K.W. Leong In vitro and in vivo models for the study of oral delivery of nanoparticles Advanced Drug Delivery Reviews 65 2013 800 810
17. H. Harde, M. Das, and S. Jain Solid lipid nanoparticles: an oral bioavailability enhancer vehicle Expert Opinion on Drug Delivery 8 2011 1407 1424
18. S. Hirsjärvi, S. Dufort, G. Bastiat, P. Saulnier, C. Passirani, J.L. Coll, and J.P. Benoît Surface modification of lipid nanocapsules with polysaccharides: from physicochemical characteristics to in vivo aspects Acta Biomaterialia 9 2013 6686 6693
19. C. Hilgendorf, H. Spahn-Langguth, C.G. Regårdh, E. Lipka, G.L. Amidon, and P. Langguth Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport Journal of Pharmaceutical Sciences 89 2000 63 75 (Pubitemid 30080155)
20. N.T. Huynh, C. Passirani, P. Saulnier, and J.P. Benoit Lipid nanocapsules: a new platform for nanomedicine International Journal of Pharmaceutics 379 2009 201 209
21. S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.Y. Wang, R. Cone, and J. Hanes Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proceedings of the National Academy of Sciences of the United States of America 104 2007 1482 1487 (Pubitemid 46214616)
22. S.K. Lai, Y.-Y. Wang, and J. Hanes Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Advanced Drug Delivery Reviews 61 2009 158 171
23. T. Lesuffleur, N. Porchet, J.P. Aubert, D. Swallow, J.R. Gum, Y.S. Kim, F.X. Real, and A. Zweibaum Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations Journal of Cell Science 106 1993 771 783 (Pubitemid 23346790)
24. J.M. Martínez Gómez, N. Csaba, S. Fischer, A. Sichelstiel, T.M. Kündig, B. Gander, and P. Johansen Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis Journal of Controlled Release 130 2008 161 167
25. F. Mathot, A. des Rieux, A. Ariën, Y.J. Schneider, M. Brewster, and V. Préat Transport mechanisms of mmePEG750P(CL-co-TMC) polymeric micelles across the intestinal barrier Journal of Controlled Release 124 2007 134 143 (Pubitemid 350110487)
26. P. Memvanga, P. Eloy, E.M. Gaigneaux, and V. Préat In vitro lipolysis and intestinal transport of β-arteether-loaded lipid-based drug delivery systems Pharmaceutical Research 30 2013 2694 2705
27. E. Merisko-Liversidge, and G.G. Liversidge Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology Advanced Drug Delivery Reviews 63 2011 427 440
28. C.E. Mora-Huertas, H. Fessi, and A. Elaissari Polymer-based nanocapsules for drug delivery International Journal of Pharmaceutics 385 2010 113 142
29. L. Plapied, N. Duhem, A. des Rieux, and V. Préat Fate of polymeric nanocarriers for oral drug delivery Current Opinion in Colloid & Interface Science 16 2011 228 237
30. M. Rescigno, M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci, J.-P. Kraehenbuhl, and P. Ricciardi-Castagnoli Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Nature Immunology 2 2001 361 367 (Pubitemid 33706348)
31. E. Roger, F. Lagarce, E. Garcion, and J.P. Benoit Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis Journal of Controlled Release 140 2009 174 181
32. J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.Y. Tinevez, D.J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona Fiji: an open-source platform for biological-image analysis Nature Methods 9 2012 676 682
33. H.H. Sigurdsson, J. Kirch, and C.M. Lehr Mucus as a barrier to lipophilic drugs International Journal of Pharmaceutics 453 2013 56 64
34. M.S. Thu, L.H. Bryant, T. Coppola, E.K. Jordan, M.D. Budde, B.K. Lewis, A. Chaudhry, J. Ren, N.R. Varma, A.S. Arbab, and J.A. Frank Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging Nature Medicine 18 2012 463 467
35. Y.-Y. Wang, S.K. Lai, J.S. Suk, A. Pace, R. Cone, and J. Hanes Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier Angewandte Chemie-International Edition 47 2008 9726 9729
36. L. Zhang, F.X. Gu, J.M. Chan, A.Z. Wang, R.S. Langer, and O.C. Farokhzad Nanoparticles in medicine: therapeutic applications and developments Clinical Pharmacology and Therapeutics 83 2008 761 769 (Pubitemid 351556021)