Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 308-314

  Chinthala, Yakaiah ^a   Kumar Domatti, Anand ^b   Sarfaraz, Alam ^c   Singh, Shailendra Pratap ^b   Kumar Arigari, Niranjan ^a   Gupta, Namita ^c   Satya, Srinivas K V N ^a   Kotesh Kumar, Jonnala ^a   Khan, Feroz ^c   Tiwari, Ashok K ^b   Paramjit, Grover ^b  

^a CSIR Central Institute of Medicinal   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

1,2,3 Triazoles; Anticancer activity; Molecular modeling study; Thiazolidinediones; Glucosidase inhibition

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [(1 4 TOLYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [(1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [(1 PHENETHYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (2 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (2 METHOXY 4 METHYLPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (2 NITROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (3,4 DIFLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (4 CHLORO 3 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; 5 [BENZO[1,3]DIOXOL 5 YLMETHYLENE] 3 [[1 (4 ISOPROPYLPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]THIAZOLIDINE 2,4 DIONE; ACARBOSE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KNOEVENAGEL CONDENSATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENICITY; NEUROBLASTOMA CELL; NONHUMAN; RAT;

1,2,3-TRIAZOLES; ANTICANCER ACTIVITY; MOLECULAR MODELING STUDY; THIAZOLIDINEDIONES; Α-GLUCOSIDASE INHIBITION;

ALPHA-GLUCOSIDASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; TRIAZOLES;

EID: 84886186607     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.005     Document Type: Article

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