The amount of self-antigen determines the effector function of murine T cells escaping negative selection

European Journal of Immunology

Volumn 44, Issue 5, 2014, Pages 1299-1312

  Swee, Lee K ^a,d   Nusser, Anja ^a   Curti, Maurus ^a,e   Kreuzaler, Matthias ^a   Rolink, Hannie ^a   Terracciano, Luigi ^b   Melchers, Fritz ^c   Andersson, Jan ^a   Rolink, Antonius ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^e Viollier AG   (Switzerland)

Author keywords

Avidity; T cells; Tolerance; Treg cell development

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERMES ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 4; L SELECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAG2 PROTEIN;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HEMATOCRIT; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PURIFYING SELECTION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; SPLENOMEGALY; T LYMPHOCYTE ACTIVATION;

AVIDITY; T CELLS; TOLERANCE; TREG-CELL DEVELOPMENT;

ANIMALS; ANTIGENS, CD11C; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY;

EID: 84899514887     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343840     Document Type: Article

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