-
1
-
-
0029999787
-
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
-
DOI 10.1038/nm0796-783
-
Alonso AC, Grundke-Iqbal I, Iqbal K. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med. 1996;2:783-787. (Pubitemid 26225094)
-
(1996)
Nature Medicine
, vol.2
, Issue.7
, pp. 783-787
-
-
Del, C.A.A.1
Grundke-Iqbal, I.2
Iqbal, K.3
-
2
-
-
84876078566
-
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation
-
Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F. The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation. Neuron. 2013;78:94-108.
-
(2013)
Neuron
, vol.78
, pp. 94-108
-
-
Mairet-Coello, G.1
Courchet, J.2
Pieraut, S.3
Courchet, V.4
Maximov, A.5
Polleux, F.6
-
3
-
-
79955566269
-
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta
-
Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Götz J, Van Leuven F, Goris J, Janssens V. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A. 2011;108:6957-6962.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 6957-6962
-
-
Louis, J.V.1
Martens, E.2
Borghgraef, P.3
Lambrecht, C.4
Sents, W.5
Longin, S.6
Zwaenepoel, K.7
Pijnenborg, R.8
Landrieu, I.9
Lippens, G.10
Ledermann, B.11
Götz, J.12
Van Leuven, F.13
Goris, J.14
Janssens, V.15
-
4
-
-
84859993199
-
Tau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation
-
Liu Y, Su Y, Sun S, Wang T, Qiao X, Run X, Liang Z. Tau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation. PLoS One. 2012;7:e35783.
-
(2012)
PLoS One
, vol.7
-
-
Liu, Y.1
Su, Y.2
Sun, S.3
Wang, T.4
Qiao, X.5
Run, X.6
Liang, Z.7
-
5
-
-
84869806297
-
Effects of treadmill exercise on the recovery of dopaminergic neuron loss and muscle atrophy in the 6-ohda lesioned parkinson's disease rat model
-
Choe MA, Koo BS, An GJ, Jeon S. Effects of treadmill exercise on the recovery of dopaminergic neuron loss and muscle atrophy in the 6-ohda lesioned parkinson's disease rat model. Korean J Physiol Pharmacol. 2012;16:305-312.
-
(2012)
Korean J Physiol Pharmacol
, vol.16
, pp. 305-312
-
-
Choe, M.A.1
Koo, B.S.2
An, G.J.3
Jeon, S.4
-
6
-
-
46249120721
-
Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: Role of tau phosphorylation
-
Mercado-Gómez O, Hernández-Fonseca K, Villavicencio- Queijeiro A, Massieu L, Chimal-Monroy J, Arias C. Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation. Neurochem Res. 2008;33:1599-1609.
-
(2008)
Neurochem Res
, vol.33
, pp. 1599-1609
-
-
Mercado-Gómez, O.1
Hernández-Fonseca, K.2
Villavicencio- Queijeiro, A.3
Massieu, L.4
Chimal-Monroy, J.5
Arias, C.6
-
7
-
-
38349190654
-
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
-
Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem. 2008;283:1882-1892.
-
(2008)
J Biol Chem
, vol.283
, pp. 1882-1892
-
-
Kuo, Y.C.1
Huang, K.Y.2
Yang, C.H.3
Yang, Y.S.4
Lee, W.Y.5
Chiang, C.W.6
-
8
-
-
77950366745
-
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta
-
Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis. 2010;19:1221-1229.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1221-1229
-
-
Qian, W.1
Shi, J.2
Yin, X.3
Iqbal, K.4
Grundke-Iqbal, I.5
Gong, C.X.6
Liu, F.7
-
9
-
-
77954123379
-
Role of presenilins in neuronal calcium homeostasis
-
Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566-8580.
-
(2010)
J Neurosci
, vol.30
, pp. 8566-8580
-
-
Zhang, H.1
Sun, S.2
Herreman, A.3
De Strooper, B.4
Bezprozvanny, I.5
-
10
-
-
34547436948
-
2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A
-
2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. Proc Natl Acad Sci U S A. 2007;104:9876-9881.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 9876-9881
-
-
Ahn, J.H.1
Sung, J.Y.2
McAvoy, T.3
Nishi, A.4
Janssens, V.5
Goris, J.6
Greengard, P.7
Nairn, A.C.8
-
11
-
-
33847317020
-
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit
-
DOI 10.1073/pnas.0611532104
-
Ahn JH, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC. Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Proc Natl Acad Sci U S A. 2007;104:2979-2984. (Pubitemid 46327989)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.8
, pp. 2979-2984
-
-
Ahn, J.-H.1
McAvoy, T.2
Rakhilin, S.V.3
Nishi, A.4
Greengard, P.5
Nairn, A.C.6
-
12
-
-
33751212191
-
Role for the PP2A/B56delta Phosphatase in Regulating 14-3-3 Release from Cdc25 to Control Mitosis
-
DOI 10.1016/j.cell.2006.10.035, PII S0092867406014139
-
Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hahn WC, Virshup DM, Kornbluth S. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 2006;127:759-773. (Pubitemid 44781028)
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 759-773
-
-
Margolis, S.S.1
Perry, J.A.2
Forester, C.M.3
Nutt, L.K.4
Guo, Y.5
Jardim, M.J.6
Thomenius, M.J.7
Freel, C.D.8
Darbandi, R.9
Ahn, J.-H.10
Arroyo, J.D.11
Wang, X.-F.12
Shenolikar, S.13
Nairn, A.C.14
Dunphy, W.G.15
Hahn, W.C.16
Virshup, D.M.17
Kornbluth, S.18
-
13
-
-
77953490407
-
Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A
-
Yu UY, Ahn JH. Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A. BMB Rep. 2010;43:263-267.
-
(2010)
BMB Rep
, vol.43
, pp. 263-267
-
-
Yu, U.Y.1
Ahn, J.H.2
-
14
-
-
84860354271
-
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: Implications for tauopathies
-
Sontag JM, Nunbhakdi-Craig V, White CL 3rd, Halpain S, Sontag E. The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem. 2012;287:14984-14993.
-
(2012)
J Biol Chem
, vol.287
, pp. 14984-14993
-
-
Sontag, J.M.1
Nunbhakdi-Craig, V.2
White III, C.L.3
Halpain, S.4
Sontag, E.5
-
15
-
-
84896865988
-
Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after wnt signaling inhibition
-
Salcedo-Tello P, Hernández-Ortega K, Arias C. Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after wnt signaling inhibition. J Alzheimers Dis. 2014;39:775-785.
-
(2014)
J Alzheimers Dis
, vol.39
, pp. 775-785
-
-
Salcedo-Tello, P.1
Hernández-Ortega, K.2
Arias, C.3
-
16
-
-
78649486194
-
Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease
-
Shin J, Yu SB, Yu UY, Jo SA, Ahn JH. Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease. BMB Rep. 2010;43:704-709.
-
(2010)
BMB Rep
, vol.43
, pp. 704-709
-
-
Shin, J.1
Yu, S.B.2
Yu, U.Y.3
Jo, S.A.4
Ahn, J.H.5
-
17
-
-
84872295381
-
B56α subunit of protein phosphatase 2A mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production in bovine aortic endothelial cells
-
Park JH, Sung HY, Lee JY, Kim HJ, Ahn JH, Jo I. B56α subunit of protein phosphatase 2A mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production in bovine aortic endothelial cells. Biochem Biophys Res Commun. 2013;430:476-481.
-
(2013)
Biochem Biophys Res Commun
, vol.430
, pp. 476-481
-
-
Park, J.H.1
Sung, H.Y.2
Lee, J.Y.3
Kim, H.J.4
Ahn, J.H.5
Jo, I.6
-
18
-
-
84872551783
-
Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration
-
Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimers Dis. 2013;33 Suppl 1:S123-139.
-
(2013)
J Alzheimers Dis
, vol.33
, Issue.SUPPL. 1
-
-
Wang, J.Z.1
Xia, Y.Y.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
19
-
-
84876027041
-
Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor
-
Kamat PK, Rai S, Swarnkar S, Shukla R, Ali S, Najmi AK, Nath C. Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor. Neuroscience. 2013;238:97-113.
-
(2013)
Neuroscience
, vol.238
, pp. 97-113
-
-
Kamat, P.K.1
Rai, S.2
Swarnkar, S.3
Shukla, R.4
Ali, S.5
Najmi, A.K.6
Nath, C.7
-
20
-
-
39949083195
-
PP2A holoenzyme assembly: In cauda venenum (the sting is in the tail)
-
Janssens V, Longin S, Goris J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci. 2008;33:113-121.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 113-121
-
-
Janssens, V.1
Longin, S.2
Goris, J.3
-
21
-
-
0036161826
-
Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A
-
DOI 10.1046/j.0014-2956.2001.02680.x
-
Li X, Virshup DM. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem. 2002;269:546-552. (Pubitemid 34128012)
-
(2002)
European Journal of Biochemistry
, vol.269
, Issue.2
, pp. 546-552
-
-
Li, X.1
Virshup, D.M.2
-
22
-
-
80054834577
-
Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A
-
Ahn JH, Kim Y, Kim HS, Greengard P, Nairn AC. Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. PLoS One. 2011;6:e26292.
-
(2011)
PLoS One
, vol.6
-
-
Ahn, J.H.1
Kim, Y.2
Kim, H.S.3
Greengard, P.4
Nairn, A.C.5
-
23
-
-
13244255645
-
PR72, a novel regulator of Wnt signaling required for Naked cuticle function
-
Creyghton MP, Roël G, Eichhorn PJ, Hijmans EM, Maurer I, Destrée O, Bernards R. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 2005;19:376-386.
-
(2005)
Genes Dev
, vol.19
, pp. 376-386
-
-
Creyghton, M.P.1
Roël, G.2
Eichhorn, P.J.3
Hijmans, E.M.4
Maurer, I.5
Destrée, O.6
Bernards, R.7
-
24
-
-
33846118688
-
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
-
DOI 10.1038/nature05351, PII NATURE05351
-
Cho US, Xu W. Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature. 2007;445:53-57. (Pubitemid 46067298)
-
(2007)
Nature
, vol.445
, Issue.7123
, pp. 53-57
-
-
Cho, U.S.1
Xu, W.2
-
25
-
-
34848843828
-
Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic subunit
-
DOI 10.1074/jbc.M704059200
-
Longin S, Zwaenepoel K, Louis JV, Dilworth S, Goris J, Janssens V. Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem. 2007;282:26971-26980. (Pubitemid 47501927)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.37
, pp. 26971-26980
-
-
Longin, S.1
Zwaenepoel, K.2
Louis, J.V.3
Dilworth, S.4
Goris, J.5
Janssens, V.6
-
26
-
-
84892941950
-
Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam
-
Arif M, Kazim SF, Grundke-Iqbal I, Garruto RM, Iqbal K. Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A. 2014;111: 1144-1149.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 1144-1149
-
-
Arif, M.1
Kazim, S.F.2
Grundke-Iqbal, I.3
Garruto, R.M.4
Iqbal, K.5
-
27
-
-
58149213742
-
Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
-
Sontag JM, Nunbhakdi-Craig V, Montgomery L, Arning E, Bottiglieri T, Sontag E. Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation. J Neurosci. 2008;28:11477-11487.
-
(2008)
J Neurosci
, vol.28
, pp. 11477-11487
-
-
Sontag, J.M.1
Nunbhakdi-Craig, V.2
Montgomery, L.3
Arning, E.4
Bottiglieri, T.5
Sontag, E.6
-
28
-
-
79959534777
-
Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau
-
Landrieu I, Smet-Nocca C, Amniai L, Louis JV, Wieruszeski JM, Goris J, Janssens V, Lippens G. Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. PLoS One. 2011;6:e21521.
-
(2011)
PLoS One
, vol.6
-
-
Landrieu, I.1
Smet-Nocca, C.2
Amniai, L.3
Louis, J.V.4
Wieruszeski, J.M.5
Goris, J.6
Janssens, V.7
Lippens, G.8
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