N-hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing smad2 and akt pathways in human colorectal adenocarcinoma cells

Chemico-Biological Interactions

Volumn 217, Issue , 2014, Pages 1-8

  Liu, Ling Yu ^a,b   Huang, Wei Jan ^b   Ho, Feng Ming ^c,d   Lin, Ren Jye ^e,f   Lin, Shyr Yi ^e,f   Suk, Fat Moon ^g   Liang, Yu Chih ^b,e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAO YUAN GENERAL HOSPITAL   (Taiwan)

^d CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; Invasion; Migration; Osthole; Smad; TGF

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; CELL PROTEIN; GELATINASE B; N HYDROXYCINNAMIDE; PROTEIN KINASE B; SMAD2 PROTEIN; SNAIL1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; WJ 1376 1; WJ 1398 1;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL TRANSFER; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MOLECULAR DYNAMICS; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

AKT; INVASION; MIGRATION; OSTHOLE; SMAD; TGF-Β;

ADENOCARCINOMA; CELL MOVEMENT; CELL SURVIVAL; COLORECTAL NEOPLASMS; COUMARINS; EPITHELIAL-MESENCHYMAL TRANSITION; HCT116 CELLS; HUMANS; HYDROXAMIC ACIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84899500214     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.04.002     Document Type: Article

References (34)

1. G.P. Tarr, A. Crowley, R. John, J.B. Kok, H.N. Lee, H. Mustafa, K.M. Sii, R. Smith, S.E. Son, L.J. Weaver, C. Cameron, J.D. Dockerty, M. Schultz, and I.A. Murray Do high risk patients alter their lifestyle to reduce risk of colorectal cancer? BMC Gastroenterol. 14 2014
2. Q.C. Zhu, R.Y. Gao, W. Wu, and H.L. Qin Epithelial-mesenchymal transition and its role in the pathogenesis of colorectal cancer Asian Pasific J. Cancer Prev. 14 2013 2689 2698
3. J. Xu, S. Lamouille, and R. Derynck TGF-beta-induced epithelial to mesenchymal transition Cell Res. 19 2009 156 172
4. M. Canel, A. Serrels, M.C. Frame, and G.B. Valerie E-cadherin-integrin crosstalk in cancer invasion and metastasis J. Cell Sci. 126 2013 393 401
5. J.S. Munger, and D. Sheppard Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix Cold Spring Harb. Perspect. Biol. 3 2011 a005017
6. P. Lampropoulos, A. Zizi-Sermpetzoglou, S. Rizos, A. Kostakis, N. Nikiteas, and A.G. Papavassiliou TGF-beta signalling in colon carcinogenesis Cancer Lett. 314 2012 1 7
7. P. Xu, J. Liu, and R. Derynck Post-translational regulation of TGF-beta receptor and Smad signaling FEBS Lett. 586 2012 1871 1884
8. J. Massague TGFβ signal transduction Annu. Rev. Biochem. 67 1998 753 791
9. K. Matsuzaki, C. Kitano, M. Murata, G. Sekimoto, K. Yoshida, Y. Uemura, T. Seki, S. Taketani, J. Fujisawa, and K. Okazaki Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer Cancer Res. 69 2009 5321 5330
10. F. Sipos, and O. Galamb Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon World J. Gastroenterol. 18 2012 601 608
11. B. Zhang, S.K. Halder, N.D. Kashikar, Y.J. Cho, A. Datta, D.L. Gorden, and P.K. Datta Antimetastatic role of Smad4 signaling in colorectal cancer Gastroenterology 138 2011 969 980
12. P. Gulhati, K.A. Bowen, J. Liu, P.D. Stevens, P.G. Rychahou, M. Chen, E.Y. Lee, H.L. Weiss, K.L. O'Connor, T. Gao, and B.M. Evers mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways Cancer Res. 71 2011 3246 3256
13. P.G. Rychahou, L.N. Jackson, S.R. Silva, S. Rajaraman, and B.M. Evers Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma Ann. Surg. 243 2006 833 844
14. S. Lamouille, and R. Derynck Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway J. Cell Biol. 178 2007 437 451 (Pubitemid 47196152)
15. J.L. Leight, M.A. Wozniak, S. Chen, M.L. Lynch, and C.S. Chen Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition Mol. Biol. Cell 23 2012 781 791
16. Y.L. Pon, H.Y. Zhou, A. Cheung, H. Ngan, and A. Wong P70 S6 Kinase promotes epithelial to mesenchymal transition through Snail induction in ovarian cancer Cancer Res. 68 2008 6524 6532
17. P. Gulhati, Q. Cai, J. Li, J. Liu, P.G. Rychahou, M. Chen, E.Y. Lee, S.R. Silva, K.A. Bowen, T. Gao, and B.M. Evers Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer Clin Cancer Res. 15 2009 7207 7216
18. S. Lamouille, E. Connolly, J.W. Smyth, R.J. Akhurst, and R. Derynck TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion J. Cell Sci. 125 2012 1259 1273
19. F.N. Ko, T.S. Wu, M.J. Liou, and C.M. Teng Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens Eur. J. Pharmacol. 219 1992 29 34
20. X. Xu, Y. Zhang, D. Qu, T. Jiang, and S. Li Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway J. Exp. Clin. Cancer Res. 30 2011 33
21. H. Matsuda, N. Tomohiro, Y. Ido, and M. kubo Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol Bio. Pharm. Bull. 25 2002 809 812 (Pubitemid 40036723)
22. P.C. Liao, S.C. Chien, C.L. Ho, E. Wang, S.C. Lee, Y.H. Kuo, N. Jeyashoke, J. Chen, W.C. Dong, L.K. Chao, and K.F. Hua Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species J. Agric. Food Chem. 58 2010 10445 10451
23. H.J. Liang, F.M. Suk, C.K. Wang, L.F. Hung, D.Z. Liu, N.Q. Chen, Y.C. Chen, C.C. Chang, and Y.C. Liang Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice Chem.-Biol. Interact. 181 2009 309 315
24. Y. Zhang, M. Xie, J. Xue, and Z. Gu Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression Planta Med. 73 2007 718 724 (Pubitemid 47234612)
25. D.Z. Tang, W. Hou, Q. Zhou, M. Zhang, J. Holz, T.J. Sheu, T.F. Li, S.D. Cheng, Q. Shi, S.E. Harris, D. Chen, and Y.J. Wang Osthole stimulates osteoblast differentiation and bone formation by activation of β-catenin-BMP Signaling J. Bone Miner. Res. 25 2010 1234 1245
26. P.L. Kuo, Y.L. Hsu, C.H. Chang, and J.K. Chang Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells J. Pharmacol. Exp. Ther. 314 2005 1290 1299
27. C.M. Hung, D.H. Kuo, C.H. Chou, Y.C. Su, C.T. Ho, and T.D. Way Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells J. Agric. Food Chem. 59 2011 9683 9690
28. L.Y. Liu, W.J. Huang, R.J. Lin, S.Y. Lin, and Y.C. Liang N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colorectal adenocarcinoma cells in vitro and in vivo Chem. Res. Toxicol. 26 2013 1683 1691
29. F.M. Suk, G.S. Lien, W.J. Huang, C.N. Chen, S.Y. Lu, Y.C. Yang, M.D. Yan, and Y.C. Liang A Taiwanese propolis derivative induces apoptosis through inducing endoplasmic reticular stress and activating transcription factor-3 in human hepatoma cells Evid. Based Complement. Alternat. Med. 2013 658370
30. P. Papageorgis, K. Cheng, S. Ozturk, Y. Gong, A.W. Lambert, H.M. Abdolmaleky, J.R. Zhou, and S. Thiagalingam Smad4 inactivation promotes malignancy and drug resistance of colon cancer Cancer Res. 71 2011 998 1008
31. R.S. Adams, E.E. Calderwood, A.E. Gould, P.D. Greenspan, M.J. LaMarche, Y. Tian, T.J. Vos, Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity, (2010) US 7652041 B2.
32. Y. Li, X. Zhu, Y. Zeng, J. Wang, X. Zhang, Y.Q. Ding, and L. Liang FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition Mol. Cancer Res. 8 12 2010 1579 1590
33. M. Korpal, and Y. Kang Targeting the transforming growth factor-beta signalling pathway in metastatic cancer Eur. J. Cancer 46 2010 1232 1240
34. Y. Li, H. Cao, Z. Jiao, S.B. Pakala, D.N.R. Sirigiri, W. Li, R. Kumar, and L. Mishra Carcinoembryonic antigen interacts with TGF-β receptor and inhibits TGF-β signaling in colorectal cancers Cancer Res. 70 2010 8159 8168