Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain

Journal of Neurochemistry

Volumn 129, Issue 4, 2014, Pages 721-731

  Hussmann, G Patrick ^a   Dedominicis, Kristen E ^a   Turner, Jill R ^b   Yasuda, Robert P ^a   Klehm, Jacquelyn ^b   Forcelli, Patrick A ^a   Xiao, Yingxian ^a   Richardson, Janell R ^a   Sahibzada, Niaz ^a   Wolfe, Barry B ^a   Lindstrom, Jon ^b   Blendy, Julie A ^b   Kellar, Kenneth J ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

nicotine; nicotine dependence; nicotinic receptor; receptor up regulation; sazetidine A; varenicline

Indexed keywords

NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; SAZETIDINE A; UNCLASSIFIED DRUG; VARENICLINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; MOUSE; NICOTINE REPLACEMENT THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SMOKING CESSATION; STEADY STATE; TOBACCO DEPENDENCE; TRANQUILIZING ACTIVITY; WEIGHT GAIN;

MUS; RATTUS; RODENTIA;

NICOTINE; NICOTINE DEPENDENCE; NICOTINIC RECEPTOR; RECEPTOR UP-REGULATION; SAZETIDINE-A; VARENICLINE;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; AZETIDINES; BENZAZEPINES; BRAIN CHEMISTRY; DRUG EVALUATION, PRECLINICAL; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE CESSATION; TOBACCO USE DISORDER; UP-REGULATION; WEIGHT GAIN;

EID: 84899492194     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12653     Document Type: Article

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