Human tobacco smokers in early abstinence have higher levels of β2* nicotinic acetylcholine receptors than nonsmokers

Journal of Neuroscience

Volumn 26, Issue 34, 2006, Pages 8707-8714

  Staley, Julie K ^a,b,e   Krishnan Sarin, Suchitra ^a   Cosgrove, Kelly P ^a,b   Krantzler, Erica ^a,b   Frohlich, Erin ^a,b   Perry, Edward ^a,b   Dubin, Joel A ^a   Estok, Kristina ^a,b   Brenner, Eric ^a,b   Baldwin, Ronald M ^a,b   Tamagnan, Gilles D ^a,b,c   Seibyl, John P ^a,c   Jatlow, Peter ^a   Picciotto, Marina R ^a   London, Edythe D ^d   O'Malley, Stephanie ^a   Van Dyck, Christopher H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c INSTITUTE FOR NEURODEGENERATIVE DISORDERS   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

Addiction; Brain; Human; Nicotine; Nicotinic acetylcholine receptor; Smokers; Thalamus

Indexed keywords

CARBON MONOXIDE; COTININE; IODINE 123; NICOTINE; NICOTINIC RECEPTOR; TRACER;

ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; EXPIRED AIR; HUMAN; MALE; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMOKING; SMOKING CESSATION; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME;

ADULT; ANIMALS; AZETIDINES; CEREBRAL CORTEX; CORPUS STRIATUM; FEMALE; HUMANS; MACACA MULATTA; MALE; MIDDLE AGED; PYRIDINES; RECEPTORS, NICOTINIC; SMOKING; SMOKING CESSATION; TOBACCO; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 33748282547     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0546-06.2006     Document Type: Article

References (54)

1. 3H]nicotine binding sites in human brain. Neuropharmacology 39:2818-2829.
2. 3H]nicotine binding site in human brain. J Neurochem 50:1243-1247.
3. 3H]nicotine binding in human postmortem brain. J Pharmacol Exp Ther 282:7-13.
4. 3H]l-nicotine in the mouse brain. Life Sci 44:1123-1132.
5. Buisson B, Bertrand D (2001) Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J Neurosci 21:1819-1829.
6. Crooks P, Dwoskin L (1997) Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking. Biochem Pharmacol 54:743-753.
7. Crooks P, Li M, Dwoskin L (1997) Metabolites of nicotine in rat brain after peripheral nicotine administration: cotinine, nornicotine, and norcotinine. Drug Metab Dispos 25:47-54.
8. Dani J, Heinemann S (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16:905-908.
9. 2 nicotinic acetylcholine receptors. J Biol Chem 280:18311-18320.
10. Esterlis I, Krishnan-Sarin S, Staley J (2006) Neurochemical substrates of habitual tobacco smoking. In: Drug abuse handbook, Ed 2 (Karch SB, ed). New York: CRC.
11. Grant B, Hasin D, Chou P, Stinson F, Dawson D (2004) Nicotine dependence and psychiatric disorders in the United States. Arch Gen Psychiatry 61:1107-1115.
12. Hariharan M, VanNoord TJFG (1988) A high performance liquid chromataographic method for routine simultaneous determination of nicotine and cotinine in plasma. Clin Chem 34:724-729.
13. Harkness P, Millar N (2002) Changes in conformation and subcellular distribution of α4β2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. J Neurosci 22:10172-10181.
14. Hatsukami D, Hughes J, Pickens R, Svikis D (1984) Tobacco withdrawal symptoms: an experimental analysis. Psychopharmacology 84:231-236.
15. Heatherton T, Kozlowski L, Frecker R, Fagerstrom K (1991) The Fagerstrom test for nicotine dependence: a revision of the Fagerstrom tolerance questionnaire. Br J Addict 86:1119-1127.
16. Horti A, Koren A, Lee K, Muhkin A, Vaupel D, Kimes A, Stratton M, London E (1999) Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2( S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors. Nucl Med Biol 26:175-182.
17. Hughes J, Hatsukami D (1986) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 43:289-294.
18. Killen J, Robinson T, Haydel K, Wilson D, Hammer L, Litt I, Taylor C (1997) Prospective study of risk factors for the initiation of cigarette smoking. J Consult Clin Psychol 65:1011-1016.
19. Lancaster J, Summerlin J, Rainey L, Freitas C, Fox P (1997) The Talairach Daemon, a database server for Talairach atlas labels. NeuroImage 5:S633.
20. Lancaster J, Woldorff M, Parsons L, Liotti M, Freitas C, Rainey L, Kochunov P, Nickerson D, Mikiten S, Fox P (2000) Automated Talairach atlas for functional brain mapping. Hum Brain Mapp 10:120-131.
21. Marks M, Burch J, Collins A (1983) Effects of chronic nicotine infusion on tolerance development and cholinergic receptors. J Pharmacol Exp Ther 226:817-825.
22. Marks M, Stitzel J, Collins A (1985) Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J Pharmacol Exp Therap 235:619-628.
23. Marks M, Pauly J, Gross S, Deneris E, Hermans-Borgmeyer I, Heinemann S, Collins A (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784.
24. 2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-649.
25. Musachio JL, Scheffel U, Finley PA, Zhan Y, Mochizuki T, Wagner Jr HN, Dannals RF (1998) 5-[I-123/125]ioo-3-(2( S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors. Life Sci 62:351-357.
26. Musachio JL, Villemagne VL, Scheffel UA, Dannals RF, Dogan AS, Yokoi F, Wong DF (1999) Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon. Nucl Med Biol 26:201-207.
27. Muzic R, Berridge M, Friedland R, Zhu N, Nelson A (1998) PET quantification of specific binding of carbon-11-nicotine in human brain. J Nucl Med 39:2048-2054.
28. 2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J Neurosci 23:11554-11567.
29. Nguyen H, Rasmussen B, Perry D (2003) Subtype-selective upregulation by chronic nicotine of high affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography. J Pharmacol Exp Ther 307:1090-1097.
30. Peng X, Gerzanich V, Anand R, Whiting P, Lindstrom J (1994) Nicotine-induced increase in neuronal nicotinic receptor results from a decrease in the rate of receptor turnover. Mol Pharmacol 46:523-530.
31. Perry D, Dávila-García M, Stockmeier C, Kellar K (1999) Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J Pharmacol Exp Ther 289:1545-1552.
32. Picciotto M, Zoli M, Rimondin R, Lena C, Marubio L, Pich E, Fuxe K, Changeux J (1998) Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 391:173-177.
33. Pietila K, Lahde T, Attila M, Ahtee L, Nordberg A (1998) Regulation of nicotinic receptors in the brain of mice withdrawn from chronic oral nicotine treatment. Naunyn Schmiedeberg Arch Pharmacol 357:176-182.
34. Rajeevan N, Zubal I, Rambsy S, Zoghbi S, Seibyl J, Innis R (1998) Significance of nonuniform attenuation correction in quantitative brain SPECT imaging. J Nucl Med 39:1719-1726.
35. Roll J, Higgins S, Badger G (1996) An experimental comparison of three different schedules of reinforcement of drug abstinence using cigarette smoking as an exemplar. J Appl Behav Anal 29:495-504.
36. Rose J, Behm F (1994) Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms. Drug Alcohol Depend 34:225-229.
37. Rousson V, Gasser T, Seifert B (2002) Assessing intrarater, interrater, and test-retest reliability of continuous measurements. Statist Med 21:3431-3446.
38. Rush R, Kuryatov A, Nelwon M, Lindstrom J (2002) First and second transmembrane segments of α3, α4, β2 and β4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine. Mol Pharmacol 61:1416-1422.
39. Sallette J, Bohler S, Benoit P, Soudant M, Pons S, Novere NL, Changeux J-P, Corringer P (2004) An extracellular protein microdomain controls upregulation of neuronal nicotinic acetylcholine receptors by nicotine. J Biol Chem 279:18767-18775.
40. Sallette J, Pons S, Devillers-Thiery A, Soudant M, Prado de Carvalho L, Changeux J-P, Corringer P (2005) Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron 46:595-607.
41. Schoedel K, Sellers E, Palmour R, Tyndale R (2003) Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Mol Pharmacol 63:96-104.
42. Schwartz R, Kellar K (1983) Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science 220:214-216.
43. Slotkin T (2002) Nicotine and the adolescent brain: insights from an animal model. Neurotoxicol Teratol 24:369-384.
44. 4 receptor antagonist L-750,667 in nonhuman primate brain. Nucl Med Biol 27:547-556.
45. Staley J, van Dyck C, Weinzimmer D, Brenner E, Baldwin R, Tamagnan G, Riccardi P, Mitsis E, Seibyl J (2005) Iodine-123-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility. J Nucl Med 46:1466-1472.
46. Stitzer M, Bigelow G (1985) Contingent reinforcement for reduced breath carbon monoxide levels: target-specific effects on cigarette smoking. Addict Behav 10:345-349.
47. Stitzer M, Rand C, Bigelow G, Mead A (1986) Contingent payment procedures for smoking reduction and cessation. J App Behav Anal 19:197-202.
48. Tiffany S, Drobes D (1991) The development and initial validation of a questionnaire on smoking urges. Br J Addict 86:1467-1476.
49. Tyndale R, Sellers E (2001) Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metab Dispos 29:548-552.
50. Vainio P, Tuominen R (2001) Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes. Nicotine Tob Res 3:177-182.
51. Wang F, Nelson M, Kuryatov A, Olale F, Cooper J, Keyser K, Lindstrom J (1998) Chronic nicotine treatment upregulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells. J Biol Chem 1998:28721-28732.
52. Wonnacott S (1990) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol Sci 11:216-219.
53. Zhang X, Gong Z-H, Hellstrom-Lindahl E, Nordberg A (1994) Regulation of α4β2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents. NeuroReport 6:313-317.
54. Zoghbi S, Tamagnan G, Fujita M, Baldwin RM, Amici L, Tikriti MA, Seibyl J, Innis R (2001) Measurement of plasma metabolites of ( S)-5-[123I]iodo-3-(2- azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates. Nucl Med Biol 28:91-96.