-
1
-
-
44449085539
-
Paul Ehrlich's magic bullet concept: 100 years of progress
-
Strebhardt K, Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 8(6), 473-480 (2008
-
(2008)
Nat. Rev. Cancer
, vol.8
, Issue.6
, pp. 473-480
-
-
Strebhardt, K.1
Ullrich, A.2
-
2
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497 (1975
-
(1975)
Nature
, vol.256
, Issue.5517
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
3
-
-
0018971622
-
Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-Associated antigen
-
Nadler LM, Stashenko P, Hardy R et al. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-Associated antigen. Cancer Res. 40(9), 3147-3154 (1980
-
(1980)
Cancer Res
, vol.40
, Issue.9
, pp. 3147-3154
-
-
Nadler, L.M.1
Stashenko, P.2
Hardy, R.3
-
4
-
-
84858797619
-
Trial Watch: Monoclonal antibodies in cancer therapy
-
Galluzzi L, Vacchelli E, Fridman WH et al. Trial Watch: Monoclonal antibodies in cancer therapy. Oncoimmunology 1(1), 28-37 (2012
-
(2012)
Oncoimmunology
, vol.1
, Issue.1
, pp. 28-37
-
-
Galluzzi, L.1
Vacchelli, E.2
Fridman, W.H.3
-
5
-
-
1842368507
-
IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
-
Maloney DG, Grillo-Lopez AJ, White CA. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90(6), 2188-2195 (1997
-
(1997)
Blood
, vol.90
, Issue.6
, pp. 2188-2195
-
-
Maloney, D.G.1
Grillo-Lopez, A.J.2
White, C.A.3
-
6
-
-
84858416256
-
Antibody-based immunotherapy of cancer
-
Weiner LM, Murray JC, Shuptrine CW. Antibody-based immunotherapy of cancer. Cell 148(6), 1081-1084 (2012
-
(2012)
Cell
, vol.148
, Issue.6
, pp. 1081-1084
-
-
Weiner, L.M.1
Murray, J.C.2
Shuptrine, C.W.3
-
7
-
-
34948858867
-
Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical
-
Zhao X, Lapalombella R, Joshi T et al. Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical. Blood 110(7), 2569-2577 (2007
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2569-2577
-
-
Zhao, X.1
Lapalombella, R.2
Joshi, T.3
-
8
-
-
79957563560
-
Therapeutic monoclonal antibodies: ScFv patents as a marker of a new class of potential biopharmaceuticals
-
Pucca MB, Bertolini TB, Barbosa JE, Galina SVR, Porto GS. Therapeutic monoclonal antibodies: ScFv patents as a marker of a new class of potential biopharmaceuticals. Braz. J. Pharm. Sci. 47, 31-38 (2011
-
(2011)
Braz. J. Pharm. Sci
, vol.47
, pp. 31-38
-
-
Pucca, M.B.1
Bertolini, T.B.2
Barbosa, J.E.3
Galina, S.V.R.4
Porto, G.S.5
-
9
-
-
61649087668
-
Glycosylation as a strategy to improve antibody-based therapeutics
-
Jefferis R. Glycosylation as a strategy to improve antibody-based therapeutics. Nat. Rev. Drug Discov. 8(3), 226-234 (2009
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, Issue.3
, pp. 226-234
-
-
Jefferis, R.1
-
10
-
-
77953659426
-
Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions
-
Moore GL, Chen H, Karki S, Lazar GA. Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions. mAbs 2(2), 181-189 (2010
-
(2010)
Mabs
, vol.2
, Issue.2
, pp. 181-189
-
-
Moore, G.L.1
Chen, H.2
Karki, S.3
Lazar, G.A.4
-
11
-
-
34548229364
-
FcRn: The neonatal Fc receptor comes of age
-
Roopenian DC, Akilesh S. FcRn: The neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7(9), 715-725 (2007
-
(2007)
Nat. Rev. Immunol
, vol.7
, Issue.9
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
12
-
-
79953316833
-
Enhanced antibody-dependent cellular phagocytosis by chimeric monoclonal antibodies with tandemly repeated Fc domains
-
Nagashima H, Ootsubo M, Fukazawa M, Motoi S, Konakahara S, Masuho Y. Enhanced antibody-dependent cellular phagocytosis by chimeric monoclonal antibodies with tandemly repeated Fc domains. J. Biosci. Bioeng. 111(4), 391-396 (2011
-
(2011)
J. Biosci. Bioeng
, vol.111
, Issue.4
, pp. 391-396
-
-
Nagashima, H.1
Ootsubo, M.2
Fukazawa, M.3
Motoi, S.4
Konakahara, S.5
Masuho, Y.6
-
13
-
-
45549090117
-
Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities
-
Natsume A M, Takamura H et al. Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities. Cancer Res. 68(10), 3863-3872 (2008
-
(2008)
Cancer Res
, vol.68
, Issue.10
, pp. 3863-3872
-
-
Natsume, A.M.1
Takamura, H.2
-
14
-
-
62449303723
-
Design and activity of a murine and humanized anti-CEACAM6 single-chain variable fragment in the treatment of pancreatic cancer
-
Riley CJ, Engelhardt KP, Saldanha JW et al. Design and activity of a murine and humanized anti-CEACAM6 single-chain variable fragment in the treatment of pancreatic cancer. Cancer Res. 69(5), 1933-1940 (2009
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 1933-1940
-
-
Riley, C.J.1
Engelhardt, K.P.2
Saldanha, J.W.3
-
15
-
-
79551575923
-
Advances in the assessment and control of the effector functions of therapeutic antibodies
-
Jiang XR, Song A, Bergelson S et al. Advances in the assessment and control of the effector functions of therapeutic antibodies. Nat. Rev. Drug Discov. 10(2), 101-111 (2011
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, Issue.2
, pp. 101-111
-
-
Jiang, X.R.1
Song, A.2
Bergelson, S.3
-
16
-
-
80051885494
-
Inhibitory Fcgamma receptor engagement drives adjuvant and anti-Tumor activities of agonistic CD40 antibodies
-
Li F, Ravetch JV Inhibitory Fcgamma receptor engagement drives adjuvant and anti-Tumor activities of agonistic CD40 antibodies. Science 333(6045), 1030-1034 (2011
-
(2011)
Science
, vol.333
, Issue.6045
, pp. 1030-1034
-
-
Li, F.1
Ravetch, J.V.2
-
17
-
-
36849087921
-
The growth and potential of human antiviral monoclonal antibody therapeutics
-
Marasco WA, Sui J The growth and potential of human antiviral monoclonal antibody therapeutics. Nature Biotechnol. 25(12), 1421-1434 (2007
-
(2007)
Nature Biotechnol
, vol.25
, Issue.12
, pp. 1421-1434
-
-
Marasco, W.A.1
Sui, J.2
-
18
-
-
80052247304
-
Harnessing the immune system's arsenal: Producing human monoclonal antibodies for therapeutics and investigating immune responses
-
Sullivan M, Kaur K, Pauli N, Wilson PC. Harnessing the immune system's arsenal: Producing human monoclonal antibodies for therapeutics and investigating immune responses. F1000 Biol Rep. 3, 17 (2011
-
(2011)
F1000 Biol Rep
, vol.3
, pp. 17
-
-
Sullivan, M.1
Kaur, K.2
Pauli, N.3
Wilson, P.C.4
-
19
-
-
17644414098
-
Tailor-made antibody therapeutics
-
Chowdhury PS, Wu H. Tailor-made antibody therapeutics. Methods 36(1), 11-24 (2005
-
(2005)
Methods
, vol.36
, Issue.1
, pp. 11-24
-
-
Chowdhury, P.S.1
Wu, H.2
-
20
-
-
2942722679
-
Antibodies and genetically engineered related molecules: Production and purification
-
Roque AC, Lowe CR, Taipa MA. Antibodies and genetically engineered related molecules: Production and purification. Biotechnol. Prog. 20(3), 639-654 (2004
-
(2004)
Biotechnol. Prog
, vol.20
, Issue.3
, pp. 639-654
-
-
Roque, A.C.1
Lowe, C.R.2
Taipa, M.A.3
-
21
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
22
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 144(5), 646-674 (2011
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
23
-
-
44449147036
-
Tumor cell metabolism: Cancer's Achilles' heel
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 13(6), 472-482 (2008
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
24
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell 136(5), 823-837 (2009
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
25
-
-
80052571556
-
Targeting intracellular oncoproteins with antibody therapy or vaccination
-
99ra85
-
Guo K, Li J, Tang JP et al. Targeting intracellular oncoproteins with antibody therapy or vaccination. Sci. Transl. Med. 3(99), 99ra85 (2011
-
(2011)
Sci. Transl. Med
, vol.3
, Issue.99
-
-
Guo, K.1
Li, J.2
Tang, J.P.3
-
26
-
-
84863788995
-
Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice
-
Guo K, Tang JP, Jie L et al. Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice. Oncotarget 3(2), 158-171 (2012
-
(2012)
Oncotarget
, vol.3
, Issue.2
, pp. 158-171
-
-
Guo, K.1
Tang, J.P.2
Jie, L.3
-
27
-
-
33746644192
-
Issues related to targeted delivery of proteins and peptides
-
Lu Y, Yang J, Sega E. Issues related to targeted delivery of proteins and peptides. AAPS J. 8(3), e466-e478 (2006
-
(2006)
AAPS J
, vol.8
, Issue.3
-
-
Lu, Y.1
Yang, J.2
Sega, E.3
-
28
-
-
21644446778
-
Arming antibodies for cancer therapy
-
Polakis P. Arming antibodies for cancer therapy. Curr. Opin. Pharmacol. 5(4), 382-387 (2005
-
(2005)
Curr. Opin. Pharmacol
, vol.5
, Issue.4
, pp. 382-387
-
-
Polakis, P.1
-
29
-
-
9444260479
-
Biological impediments to monoclonal antibody-based cancer immunotherapy
-
Christiansen J, Rajasekaran AK. Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol. Cancer Ther. 3(11), 1493-1501 (2004
-
(2004)
Mol. Cancer Ther
, vol.3
, Issue.11
, pp. 1493-1501
-
-
Christiansen, J.1
Rajasekaran, A.K.2
-
30
-
-
84864367360
-
The ERBB network: At last, cancer therapy meets systems biology
-
Yarden Y, Pines G. The ERBB network: At last, cancer therapy meets systems biology. Nat. Rev. Cancer 12(8), 553-563 (2012
-
(2012)
Nat. Rev. Cancer
, vol.12
, Issue.8
, pp. 553-563
-
-
Yarden, Y.1
Pines, G.2
-
31
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 27(5), 663-671 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.5
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
32
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J. Clin. Oncol. 29(15), 2011-2019 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.15
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
33
-
-
73249143536
-
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11(1), 21-28 (2010
-
(2010)
Lancet Oncol
, vol.11
, Issue.1
, pp. 21-28
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
34
-
-
51649085865
-
Platinum-based chemotherapy plus cetuximab in head and neck cancer
-
Vermorken JB, Mesia R, Rivera F et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359(11), 1116-1127 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, Issue.11
, pp. 1116-1127
-
-
Vermorken, J.B.1
Mesia, R.2
Rivera, F.3
-
35
-
-
34147103678
-
Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S et al. Open-label Phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 25(13), 1658-1664 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
36
-
-
78149250536
-
Randomized, phase iii trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (folfox4) versus folfox4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The prime study
-
Douillard JY, Siena S, Cassidy J et al. Randomized, Phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study. J. Clin. Oncol. 28(31), 4697-4705 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.31
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
-
37
-
-
78149239651
-
Randomized phase iii study of panitumumab with fluorouracil, leucovorin, and irinotecan (folfiri) compared with folfiri alone as second-line treatment in patients with metastatic colorectal cancer
-
Peeters M, Price TJ, Cervantes A et al. Randomized Phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J. Clin. Oncol. 28(31), 4706-4713 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.31
, pp. 4706-4713
-
-
Peeters, M.1
Price, T.J.2
Cervantes, A.3
-
38
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344(11), 783-792 (2001
-
(2001)
N. Engl. J. Med
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
39
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1659-1672 (2005
-
(2005)
N. Engl. J. Med
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
40
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005
-
(2005)
N. Engl. J. Med
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
41
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A Phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A Phase 3, open-label, randomised controlled trial. Lancet 376(9742), 687-697 (2010
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
42
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N. Engl. J. Med. 366(2), 109-119 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.2
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
43
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350(23), 2335-2342 (2004
-
(2004)
N. Engl. J. Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
44
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 25(12), 1539-1544 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.12
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
45
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 355(24), 2542-2550 (2006
-
(2006)
N. Engl. J. Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
46
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27(28), 4733-4740 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.28
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
47
-
-
59949083263
-
Phase II trial of single-Agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K et al. Phase II trial of single-Agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J. Clin. Oncol. 27(5), 740-745 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.5
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
48
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial
-
Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind Phase III trial. Lancet 370(9605), 2103-2111 (2007
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
49
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J. Clin. Oncol. 26(33), 5422-5428 (2008
-
(2008)
J. Clin. Oncol
, vol.26
, Issue.33
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
50
-
-
77954700380
-
Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Miles DW, Chan A, Dirix LY et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 28(20), 3239-3247 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.20
, pp. 3239-3247
-
-
Miles, D.W.1
Chan, A.2
Dirix, L.Y.3
-
51
-
-
84855425106
-
Incorporation of bevacizumab in the primary treatment of ovarian cancer
-
Burger RA, Brady MF, Bookman MA et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N. Engl. J. Med. 365(26), 2473-2483 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, Issue.26
, pp. 2473-2483
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
-
52
-
-
84855466019
-
A Phase 3 trial of bevacizumab in ovarian cancer
-
Perren TJ, Swart AM, Pfisterer J et al. A Phase 3 trial of bevacizumab in ovarian cancer. N. Engl. J. Med. 365(26), 2484-2496 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, Issue.26
, pp. 2484-2496
-
-
Perren, T.J.1
Swart, A.M.2
Pfisterer, J.3
-
53
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a Phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a Phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J. Clin. Oncol. 30(28), 3499-3506 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.28
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
54
-
-
58749109167
-
Cancer and immune response: Old and new evidence for future challenges
-
De La Cruz-Merino L, Grande-Pulido E, Albero-Tamarit A, Codes-Manuel De Villena ME. Cancer and immune response: Old and new evidence for future challenges. Oncologist 13(12), 1246-1254 (2008
-
(2008)
Oncologist
, vol.13
, Issue.12
, pp. 1246-1254
-
-
De La Cruz-Merino, L.1
Grande-Pulido, E.2
Albero-Tamarit, A.3
Codes-Manuel De Villena, M.E.4
-
55
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270(5238), 985-988 (1995
-
(1995)
Science
, vol.270
, Issue.5238
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
-
56
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat. Rev. Cancer 7(2), 95-106 (2007
-
(2007)
Nat. Rev. Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
57
-
-
79957917538
-
Ipilimumab
-
Sondak VK, Smalley KS, Kudchadkar R, Grippon S, Kirkpatrick P. Ipilimumab. Nat. Rev. Drug Discov. 10(6), 411-412 (2011
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, Issue.6
, pp. 411-412
-
-
Sondak, V.K.1
Smalley, K.S.2
Kudchadkar, R.3
Grippon, S.4
Kirkpatrick, P.5
-
58
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
59
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364(26), 2517-2526 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
60
-
-
79551568488
-
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study
-
Stopeck AT, Lipton A, Body JJ et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study. J. Clin. Oncol. 28(35), 5132-5139 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.35
, pp. 5132-5139
-
-
Stopeck, A.T.1
Lipton, A.2
Body, J.J.3
-
61
-
-
84867582660
-
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, Phase 3 trials
-
Lipton A, Fizazi K, Stopeck AT et al. Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, Phase 3 trials. Eur. J. Cancer 48(16), 3082-3092 (2012
-
(2012)
Eur. J. Cancer
, vol.48
, Issue.16
, pp. 3082-3092
-
-
Lipton, A.1
Fizazi, K.2
Stopeck, A.T.3
-
62
-
-
77954676136
-
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized Phase II/III trial
-
Heiss MM, Murawa P, Koralewski P et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized Phase II/III trial. Int. J. Cancer 127(9), 2209-2221 (2010
-
(2010)
Int. J. Cancer
, vol.127
, Issue.9
, pp. 2209-2221
-
-
Heiss, M.M.1
Murawa, P.2
Koralewski, P.3
-
63
-
-
0642312825
-
Rituximab (monoclonal anti-CD20 antibody): Mechanisms of action and resistance
-
Smith MR. Rituximab (monoclonal anti-CD20 antibody): Mechanisms of action and resistance. Oncogene 22(47), 7359-7368 (2003
-
(2003)
Oncogene
, vol.22
, Issue.47
, pp. 7359-7368
-
-
Smith, M.R.1
-
64
-
-
77950326933
-
CD20-Targeted therapy: The next generation of antibodies
-
Van Meerten T, Hagenbeek A. CD20-Targeted therapy: The next generation of antibodies. Semin. Hematol. 47(2), 199-210 (2010
-
(2010)
Semin. Hematol
, vol.47
, Issue.2
, pp. 199-210
-
-
Van Meerten, T.1
Hagenbeek, A.2
-
65
-
-
79952720110
-
The future of anti-CD20 monoclonal antibodies: Are we making progress?
-
Alduaij W, Illidge TM The future of anti-CD20 monoclonal antibodies: Are we making progress? Blood 117(11), 2993-3001 (2011
-
(2011)
Blood
, vol.117
, Issue.11
, pp. 2993-3001
-
-
Alduaij, W.1
Illidge, T.M.2
-
67
-
-
77956250271
-
US Food and Drug Administration approval: Ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab
-
Lemery SJ, Zhang J, Rothmann MD et al. US Food and Drug Administration approval: Ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab. Clin. Cancer Res. 16(17), 4331-4338 (2010
-
(2010)
Clin. Cancer Res
, vol.16
, Issue.17
, pp. 4331-4338
-
-
Lemery, S.J.1
Zhang, J.2
Rothmann, M.D.3
-
68
-
-
0036796192
-
Zevalin: The first radioimmunotherapy approved for the treatment of lymphoma
-
Grillo-Lopez AJ. Zevalin: The first radioimmunotherapy approved for the treatment of lymphoma. Expert Rev. Anticancer Ther. 2(5), 485-493 (2002
-
(2002)
Expert Rev. Anticancer Ther
, vol.2
, Issue.5
, pp. 485-493
-
-
Grillo-Lopez, A.J.1
-
69
-
-
15944417153
-
Tositumomab and iodine [131I] tositumomab in the management of follicular lymphoma An oncologist's view
-
Davies AJ. Tositumomab and iodine [131I] tositumomab in the management of follicular lymphoma. An oncologist's view. Q. J. Nucl. Med. Mol. Imaging 48(4), 305-316 (2004
-
(2004)
Q. J. Nucl. Med. Mol. Imaging
, vol.48
, Issue.4
, pp. 305-316
-
-
Davies, A.J.1
-
70
-
-
84873053339
-
Antibody-drug conjugates in cancer therapy
-
Sievers EL, Senter PD. Antibody-drug conjugates in cancer therapy. Ann. Rev. Med. 64, 15-29 (2013
-
(2013)
Ann. Rev. Med
, vol.64
, pp. 15-29
-
-
Sievers, E.L.1
Senter, P.D.2
-
71
-
-
84868561570
-
US Food and Drug Administration approval summary: Brentuximab vedotin for the treatment of relapsed Hodgkin lymphoma or relapsed systemic anaplastic large-cell lymphoma
-
De Claro RA, Mcginn K, Kwitkowski V et al. US Food and Drug Administration approval summary: Brentuximab vedotin for the treatment of relapsed Hodgkin lymphoma or relapsed systemic anaplastic large-cell lymphoma. Clin. Cancer Res. 18(21), 5845-5849 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.21
, pp. 5845-5849
-
-
De Claro, R.A.1
Mcginn, K.2
Kwitkowski, V.3
-
72
-
-
84875467346
-
Brentuximab vedotin: A CD30-directed antibody-cytotoxic drug conjugate
-
Newland AM, Li JX, Wasco LE, Aziz MT, Lowe DK. Brentuximab vedotin: A CD30-directed antibody-cytotoxic drug conjugate. Pharmacotherapy 33(1), 93-104 (2013
-
(2013)
Pharmacotherapy
, vol.33
, Issue.1
, pp. 93-104
-
-
Newland, A.M.1
Li, J.X.2
Wasco, L.E.3
Aziz, M.T.4
Lowe, D.K.5
-
73
-
-
0032699774
-
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor
-
Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur. J. Immunol. 29(11), 3440-3449 (1999
-
(1999)
Eur. J. Immunol
, vol.29
, Issue.11
, pp. 3440-3449
-
-
Ulyanova, T.1
Blasioli, J.2
Woodford-Thomas, T.A.3
Thomas, M.L.4
-
74
-
-
0034900174
-
Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
-
Bross PF, Beitz J, Chen G et al. Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin. Cancer Res. 7(6), 1490-1496 (2001
-
(2001)
Clin. Cancer Res
, vol.7
, Issue.6
, pp. 1490-1496
-
-
Bross, P.F.1
Beitz, J.2
Chen, G.3
-
75
-
-
77957711298
-
Preliminary results of Southwest Oncology Group Study S0106: An international intergroup Phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia
-
Petersdorf S, Kopecky K, Stuart RK et al. Preliminary results of Southwest Oncology Group Study S0106: An international intergroup Phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia. Blood 114(22), 790 (2009
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 790
-
-
Petersdorf, S.1
Kopecky, K.2
Stuart, R.K.3
-
76
-
-
84869434807
-
Gemtuzumab ozogamicin: Time to resurrect?
-
Ravandi F, Estey EH, Appelbaum FR et al. Gemtuzumab ozogamicin: Time to resurrect? J. Clin. Oncol. 30(32), 3921-3923 (2012
-
(2012)
J Clin. Oncol
, vol.30
, Issue.32
, pp. 3921-3923
-
-
Ravandi, F.1
Estey, E.H.2
Appelbaum, F.R.3
-
77
-
-
23044471884
-
Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia
-
Feldman EJ, Brandwein J, Stone R et al. Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. J. Clin. Oncol. 23(18), 4110-4116 (2005
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.18
, pp. 4110-4116
-
-
Feldman, E.J.1
Brandwein, J.2
Stone, R.3
-
78
-
-
40349114506
-
FDA drug approval summary: Alemtuzumab as single-Agent treatment for B-cell chronic lymphocytic leukemia
-
Demko S, Summers J, Keegan P, Pazdur R. FDA drug approval summary: Alemtuzumab as single-Agent treatment for B-cell chronic lymphocytic leukemia. Oncologist 13(2), 167-174 (2008
-
(2008)
Oncologist
, vol.13
, Issue.2
, pp. 167-174
-
-
Demko, S.1
Summers, J.2
Keegan, P.3
Pazdur, R.4
-
79
-
-
78649471912
-
Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: A retrospective study on various cytogenetic risk categories
-
Fiegl M, Erdel M, Tinhofer I et al. Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: A retrospective study on various cytogenetic risk categories. Ann. Oncol. 21(12), 2410-2419 (2010
-
(2010)
Ann. Oncol
, vol.21
, Issue.12
, pp. 2410-2419
-
-
Fiegl, M.1
Erdel, M.2
Tinhofer, I.3
-
80
-
-
0038315416
-
Radiolabeled monoclonal antibodies specific to the extracellular domain of prostatespecific membrane antigen: Preclinical studies in nude mice bearing LNCaP human prostate tumor
-
Smith-Jones PM, Vallabhajosula S, Navarro V, Bastidas D, Goldsmith SJ, Bander NH. Radiolabeled monoclonal antibodies specific to the extracellular domain of prostatespecific membrane antigen: Preclinical studies in nude mice bearing LNCaP human prostate tumor. J. Nucl. Med. 44(4), 610-617 (2003
-
(2003)
J. Nucl. Med
, vol.44
, Issue.4
, pp. 610-617
-
-
Smith-Jones, P.M.1
Vallabhajosula, S.2
Navarro, V.3
Bastidas, D.4
Goldsmith, S.J.5
Bander, N.H.6
-
81
-
-
77956193105
-
89Zr-DFO-J591 for immunoPET of prostatespecific membrane antigen expression in vivo
-
Holland JP, Divilov V, Bander NH, Smith-Jones PM, Larson SM, Lewis JS. 89Zr-DFO-J591 for immunoPET of prostatespecific membrane antigen expression in vivo. J. Nucl. Med. 51(8), 1293-1300 (2010
-
(2010)
J. Nucl. Med
, vol.51
, Issue.8
, pp. 1293-1300
-
-
Holland, J.P.1
Divilov, V.2
Bander, N.H.3
Smith-Jones, P.M.4
Larson, S.M.5
Lewis, J.S.6
-
83
-
-
77954899030
-
Phase I study of single-Agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I et al. Phase I study of single-Agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates. J. Clin. Oncol. 28(19), 3167-3175 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
84
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369(2), 122-133 (2013
-
(2013)
N. Engl. J. Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
85
-
-
83755168244
-
PET with the 89Zr-labeled transforming growth factor-beta antibody fresolimumab in tumor models
-
Oude Munnink TH, Arjaans ME, Timmer-Bosscha H et al. PET with the 89Zr-labeled transforming growth factor-beta antibody fresolimumab in tumor models. J. Nucl. Med. 52(12), 2001-2008 (2011
-
(2011)
J. Nucl. Med
, vol.52
, Issue.12
, pp. 2001-2008
-
-
Oude Munnink, T.H.1
Arjaans, M.E.2
Timmer-Bosscha, H.3
-
88
-
-
84856008240
-
Differentiation between the EGFR antibodies necitumumab, cetuximab and panitumumab: In vitro biological and binding activities
-
Abstract e13030
-
Saxena B, Sundaram ST, Walton W et al. Differentiation between the EGFR antibodies necitumumab, cetuximab and panitumumab: In vitro biological and binding activities. J. Clin. Oncol. 29(Suppl. 15), Abstract e13030 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.SUPPL. 15
-
-
Saxena, B.1
Sundaram, S.T.2
Walton, W.3
-
91
-
-
77953664765
-
Nimotuzumab a promising therapeutic monoclonal for treatment of tumors of epithelial origin
-
Ramakrishnan MS, Eswaraiah A, Crombet T et al. Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin. mAbs 1(1), 41-48 (2009
-
(2009)
Mabs
, vol.1
, Issue.1
, pp. 41-48
-
-
Ramakrishnan, M.S.1
Eswaraiah, A.2
Crombet, T.3
-
92
-
-
77954031486
-
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
-
Krop IE, Beeram M, Modi S et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J. Clin. Oncol. 28(16), 2698-2704 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.16
, pp. 2698-2704
-
-
Krop, I.E.1
Beeram, M.2
Modi, S.3
-
93
-
-
84863688392
-
A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
-
Krop IE, Lorusso P, Miller KD et al. A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. J. Clin. Oncol. 30(26), 3234-3241 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.26
, pp. 3234-3241
-
-
Krop, I.E.1
Lorusso, P.2
Miller, K.D.3
-
94
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N. Engl. J. Med. 367(19), 1783-1791 (2012
-
(2012)
N. Engl. J. Med
, vol.367
, Issue.19
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
97
-
-
84875217930
-
A randomised, double-blind, placebo-controlled Phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma
-
Peeters M, Strickland AH, Lichinitser M et al. A randomised, double-blind, placebo-controlled Phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma. Br. J. Cancer 108(3), 503-511 (2013
-
(2013)
Br. J. Cancer
, vol.108
, Issue.3
, pp. 503-511
-
-
Peeters, M.1
Strickland, A.H.2
Lichinitser, M.3
-
98
-
-
84874566567
-
Phase II randomized, double-blind, placebo-controlled study of AMG 386 (trebananib) in combination with cisplatin and capecitabine in patients with metastatic gastro-oesophageal cancer
-
Eatock MM, Tebbutt NC, Bampton CL et al. Phase II randomized, double-blind, placebo-controlled study of AMG 386 (trebananib) in combination with cisplatin and capecitabine in patients with metastatic gastro-oesophageal cancer. Ann. Oncol. 24(3), 710-718 (2013
-
(2013)
Ann. Oncol
, vol.24
, Issue.3
, pp. 710-718
-
-
Eatock, M.M.1
Tebbutt, N.C.2
Bampton, C.L.3
-
99
-
-
84899471188
-
A Phase Ib/II study evaluating the efficacy of doxorubicin D) with or without a human anti-PDGFRa monoclonal antibody olaratumab (IMC-3G3) in the treatment of advanced soft tissue sarcoma (STS
-
Suppl.), Abstract TPS10099
-
Tap WD, Van Tine BA, Elias AD et al. A Phase Ib/II study evaluating the efficacy of doxorubicin (D) with or without a human anti-PDGFRa monoclonal antibody olaratumab (IMC-3G3) in the treatment of advanced soft tissue sarcoma (STS). J. Clin. Oncol. 30(Suppl.), Abstract TPS10099 (2012
-
(2012)
J. Clin. Oncol
, Issue.30
-
-
Tap, W.D.1
Van Tine, B.A.2
Elias, A.D.3
-
102
-
-
84861733799
-
MET: A promising anticancer therapeutic target
-
Peters S, Adjei AA. MET: A promising anticancer therapeutic target. Nat. Rev. Clin. Oncol. 9(6), 314-326 (2012
-
(2012)
Nat. Rev. Clin. Oncol
, vol.9
, Issue.6
, pp. 314-326
-
-
Peters, S.1
Adjei, A.A.2
-
103
-
-
77958463931
-
Phase i study of sch900105 (sc an anti-heaptocyte growth factor (hgf) monoclonal ab (mab), as a single agent and in combination with erlotinnib (e) in patients with advanced solid tumors
-
Abstract
-
Patnaik A, Weiss GJ, Papadopoulos K et al. Phase I study of SCH900105 (SC), an anti-heaptocyte growth factor (HGF) monoclonal ab (Mab), as a single agent and in combination with erlotinnib (E) in patients with advanced solid tumors. J. Clin. Oncol. 28(Suppl. 15), Abstract 2525 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.SUPPL. 15
, pp. 2525
-
-
Patnaik, A.1
Weiss, G.J.2
Papadopoulos, K.3
-
104
-
-
84872214179
-
Phase ib study of ficlatuzumab (formerly av-299 an anti-hepatocyte growth factor (hgf) monoclonal antibody (mab) in combination with gefitinib (g) in asian patients (pts) with nsclc
-
Suppl.), Abstract
-
Tan E, Park K, Lim WT et al. Phase IB study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC. J. Clin. Oncol. 29(Suppl.), Abstract 7571 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 7571
-
-
Tan, E.1
Park, K.2
Lim, W.T.3
-
105
-
-
84872214179
-
Randomized phase ii study of ficlatuzumab (formerly av-299), an anti-hepatocyte growth factor (hgf) monoclonal antibody (mab) in combination with gefitinib (g) in asian patients (pts) with nsclc
-
Suppl.), Abstract TPS213
-
Mok T, Tan E, Park K et al. Randomized Phase II study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC. J. Clin. Oncol. 29(Suppl.), Abstract TPS213 (2011
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Mok, T.1
Tan, E.2
Park, K.3
-
106
-
-
78549291444
-
Safety, tolerability, and pharmacokinetics of TAK-701, a humanized anti-hepatocyte growth factor (HGF) monoclonal antibody, in patients with advanced nonhematologic malignancies: First-in-human Phase I dose-escalation study
-
Abstract
-
Jones SF, Cohen RB, Bendell J C et al. Safety, tolerability, and pharmacokinetics of TAK-701, a humanized anti-hepatocyte growth factor (HGF) monoclonal antibody, in patients with advanced nonhematologic malignancies: First-in-human Phase I dose-escalation study. J. Clin. Oncol. 28(Suppl. 15), Abstract 3081 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.SUPPL. 15
, pp. 3081
-
-
Jones, S.F.1
Cohen, R.B.2
Bendell J, C.3
-
107
-
-
74549174584
-
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factorneutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors
-
Gordon MS, Sweeney CS, Mendelson DS et al. Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factorneutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Clin. Cancer Res. 16(2), 699-710 (2010
-
(2010)
Clin. Cancer Res
, vol.16
, Issue.2
, pp. 699-710
-
-
Gordon, M.S.1
Sweeney, C.S.2
Mendelson, D.S.3
-
108
-
-
77951760333
-
A Phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors
-
Rosen PJ, Sweeney CJ, Park DJ et al. A Phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors. Clin. Cancer Res. 16(9), 2677-2687 (2010
-
(2010)
Clin. Cancer Res
, vol.16
, Issue.9
, pp. 2677-2687
-
-
Rosen, P.J.1
Sweeney, C.J.2
Park, D.J.3
-
109
-
-
80054746340
-
A randomized phase ib/ii trial of rilotumumab (amg 102; ril) or ganitumab (amg 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-Type (wt) kras metastatic colorectal cancer (mcrc): Primary and biomarker analyses
-
Abstract
-
Eng C, Van Cutsem E, Nowara A et al. A randomized, Phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-Type (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses. J. Clin. Oncol. 29(Suppl. 15), Abstract 3500 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.SUPPL. 15
, pp. 3500
-
-
Eng, C.1
Van Cutsem, E.2
Nowara, A.3
-
110
-
-
79955766450
-
A Phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma
-
Wen PY, Schiff D, Cloughesy TF et al. A Phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol. 13(4), 437-446 (2011
-
(2011)
Neuro Oncol
, vol.13
, Issue.4
, pp. 437-446
-
-
Wen, P.Y.1
Schiff, D.2
Cloughesy, T.F.3
-
111
-
-
80051991655
-
A Phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma
-
Schoffski P, Garcia JA, Stadler WM et al. A Phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma. BJU Int. 108(5), 679-686 (2011
-
(2011)
BJU Int
, vol.108
, Issue.5
, pp. 679-686
-
-
Schoffski, P.1
Garcia, J.A.2
Stadler, W.M.3
-
112
-
-
84871962904
-
Targeted MET inhibition in castration-resistant prostate cancer: A randomized Phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
-
Ryan CJ, Rosenthal M, Ng S et al. Targeted MET inhibition in castration-resistant prostate cancer: A randomized Phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin. Cancer Res. 19(1), 215-224 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.1
, pp. 215-224
-
-
Ryan, C.J.1
Rosenthal, M.2
Ng, S.3
-
113
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
Spigel DR, Ervin TJ, Ramlau R et al. Final efficacy results from OAM4558g, a randomized Phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J. Clin. Oncol. 29(Suppl. 15), 7505 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.SUPPL. 15
, pp. 7505
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
-
114
-
-
84871584457
-
The metlung study: A randomized, doubleblind, phase iii study of onartuzumab (metmab) plus erlotinib versus placebo plus erlotinib in patients with advanced, met-positive non-small cell lung cancer (nsclc
-
Abstract TPS
-
Spigel DR, Edelman MJ, Mok T et al. The MetLUNG study: A randomized, doubleblind, Phase III study of onartuzumab (MetMAb) plus erlotinib versus placebo plus erlotinib in patients with advanced, MET-positive non-small cell lung cancer (NSCLC). J. Clin. Oncol. 30(Suppl. 15), Abstract TPS7616 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.SUPPL. 15
, pp. 7616
-
-
Spigel, D.R.1
Edelman, M.J.2
Mok, T.3
-
118
-
-
78449243489
-
Immune checkpoint proteins: A new therapeutic paradigm for cancer - preclinical background: CTLA-4 and PD-1 blockade
-
Weber J. Immune checkpoint proteins: A new therapeutic paradigm for cancer - preclinical background: CTLA-4 and PD-1 blockade. Semin. Oncol. 37(5), 430-439 (2010
-
(2010)
Semin. Oncol
, vol.37
, Issue.5
, pp. 430-439
-
-
Weber, J.1
-
119
-
-
84874889330
-
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
-
Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin. Cancer Res. 19(5), 997-1008 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.5
, pp. 997-1008
-
-
Melero, I.1
Grimaldi, A.M.2
Perez-Gracia, J.L.3
Ascierto, P.A.4
-
120
-
-
84874909144
-
Agonist antibodies to tnfr molecules that costimulate t and nk cells
-
Melero I, Hirschhorn-Cymerman D, Morales-Kastresana A, Sanmamed MF, Wolchok JD. Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clin. Cancer Res. 19(5), 1044-1053 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.5
, pp. 1044-1053
-
-
Melero, I.1
Hirschhorn-Cymerman, D.2
Morales-Kastresana, A.3
Sanmamed, M.F.4
Wolchok, J.D.5
-
121
-
-
84879733796
-
Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response
-
Tseng D, Volkmer J-P, Willingham SB et al. Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc. Natl Acad. Sci. USA 110(27), 11103-11108 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, Issue.27
, pp. 11103-11108
-
-
Tseng, D.1
Volkmer, J.-P.2
Willingham, S.B.3
-
122
-
-
84869787349
-
Immunotherapies: The blockade of inhibitory signals
-
Wu YL, Liang J, Zhang W, Tanaka Y, Sugiyama H. Immunotherapies: The blockade of inhibitory signals. Int. J. Biol. Sci. 8(10), 1420-1430 (2012
-
(2012)
Int. J. Biol. Sci
, vol.8
, Issue.10
, pp. 1420-1430
-
-
Wu, Y.L.1
Liang, J.2
Zhang, W.3
Tanaka, Y.4
Sugiyama, H.5
-
123
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
125
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
126
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas A, Kefford R, Marshall MA et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 31(5), 616-622 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.5
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
-
127
-
-
84867858547
-
Blinatumomab: A historical perspective
-
Nagorsen D, Kufer P, Baeuerle PA, Bargou R. Blinatumomab: A historical perspective. Pharmacol. Ther. 136(3), 334-342 (2012
-
(2012)
Pharmacol. Ther
, vol.136
, Issue.3
, pp. 334-342
-
-
Nagorsen, D.1
Kufer, P.2
Baeuerle, P.A.3
Bargou, R.4
-
128
-
-
84871491706
-
Long-Term follow-up of hematologic relapse-free survival in a Phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
-
Topp MS, Gokbuget N, Zugmaier G et al. Long-Term follow-up of hematologic relapse-free survival in a Phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 120(26), 5185-5187 (2012
-
(2012)
Blood
, vol.120
, Issue.26
, pp. 5185-5187
-
-
Topp, M.S.1
Gokbuget, N.2
Zugmaier, G.3
-
129
-
-
84864544136
-
Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma
-
Younes A, Kim S, Romaguera J et al. Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma. J. Clin. Oncol. 30(22), 2776-2782 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.22
, pp. 2776-2782
-
-
Younes, A.1
Kim, S.2
Romaguera, J.3
-
132
-
-
84864144129
-
CD22 and Siglec-G in B cell function and tolerance
-
Poe JC, Tedder TF. CD22 and Siglec-G in B cell function and tolerance. Trends Immunol. 33(8), 413-420 (2012
-
(2012)
Trends Immunol
, vol.33
, Issue.8
, pp. 413-420
-
-
Poe, J.C.1
Tedder, T.F.2
-
133
-
-
79551588807
-
Beyond chemotherapy: New agents for targeted treatment of lymphoma
-
Younes A. Beyond chemotherapy: New agents for targeted treatment of lymphoma. Nat. Rev. Clin. Oncol. 8(2), 85-96 (2011
-
(2011)
Nat. Rev. Clin. Oncol
, vol.8
, Issue.2
, pp. 85-96
-
-
Younes, A.1
-
134
-
-
0042413843
-
Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma
-
Leonard JP, Coleman M, Ketas JC et al. Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma. J. Clin. Oncol. 21(16), 3051-3059 (2003
-
(2003)
J. Clin. Oncol
, vol.21
, Issue.16
, pp. 3051-3059
-
-
Leonard, J.P.1
Coleman, M.2
Ketas, J.C.3
-
135
-
-
80054098574
-
Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma
-
Micallef IN, Maurer MJ, Wiseman GA et al. Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma. Blood 118(15), 4053-4061 (2011
-
(2011)
Blood
, vol.118
, Issue.15
, pp. 4053-4061
-
-
Micallef, I.N.1
Maurer, M.J.2
Wiseman, G.A.3
-
136
-
-
84875434050
-
Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: Results of a Phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab
-
Fayad L, Offner F, Smith MR et al. Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: Results of a Phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab. J. Clin. Oncol. 31(5), 573-583 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.5
, pp. 573-583
-
-
Fayad, L.1
Offner, F.2
Smith, M.R.3
-
138
-
-
84883236868
-
A Phase I study of DCDT2980S, an antibody-drug conjugate (ADC) targeting CD22, in relapsed or refractory B-cell non-hodgkin's lymphoma (NHL
-
Abstract
-
Advani R, Lebovic D, Brunvand M et al. A Phase I study of DCDT2980S, an antibody-drug conjugate (ADC) targeting CD22, in relapsed or refractory B-cell non-hodgkin's lymphoma (NHL). Blood 120(21), Abstract 59 (2012
-
(2012)
Blood
, vol.120
, Issue.21
, pp. 59
-
-
Advani, R.1
Lebovic, D.2
Brunvand, M.3
-
140
-
-
84861542159
-
Phase i trial of anti-cd22 recombinant immunotoxin moxetumomab pasudotox (cat-8015 or ha22) in patients with hairy cell leukemia
-
Kreitman RJ, Tallman MS, Robak T et al. Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J. Clin. Oncol. 30(15), 1822-1828 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.15
, pp. 1822-1828
-
-
Kreitman, R.J.1
Tallman, M.S.2
Robak, T.3
-
141
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 463(7277), 88-92 (2010
-
(2010)
Nature
, vol.463
, Issue.7277
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
142
-
-
84883236868
-
A Phase I study of the anti-CD79b antibody-drug conjugate (ADC) DCDS4501A targeting CD79b in relapsed or refractory B-cell non-hodgkin's lymphoma (NHL
-
Abstract
-
Palanca-Wessels MC, Flinn IW, Sehn LH et al. A Phase I study of the anti-CD79b antibody-drug conjugate (ADC) DCDS4501A targeting CD79b in relapsed or refractory B-cell non-hodgkin's lymphoma (NHL). Blood 120(21), Abstract 56 (2012
-
(2012)
Blood
, vol.120
, Issue.21
, pp. 56
-
-
Palanca-Wessels, M.C.1
Flinn, I.W.2
Sehn, L.H.3
-
143
-
-
0036606950
-
CD200 and membrane protein interactions in the control of myeloid cells
-
Barclay AN, Wright GJ, Brooke G, Brown MH. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol. 23(6), 285-290 (2002
-
(2002)
Trends Immunol
, vol.23
, Issue.6
, pp. 285-290
-
-
Barclay, A.N.1
Wright, G.J.2
Brooke, G.3
Brown, M.H.4
-
144
-
-
78049490002
-
CD200 (OX-2 membrane glycoprotein) expression in B cell-derived neoplasms
-
Dorfman DM, Shahsafaei A. CD200 (OX-2 membrane glycoprotein) expression in B cell-derived neoplasms. Am. J. Clin. Pathol. 134(5), 726-733 (2010
-
(2010)
Am. J. Clin. Pathol
, vol.134
, Issue.5
, pp. 726-733
-
-
Dorfman, D.M.1
Shahsafaei, A.2
-
145
-
-
40449088359
-
Blockade of CD200 in the presence or absence of antibody effector function: Implications for anti-CD200 therapy
-
Kretz-Rommel A, Qin F, Dakappagari N, Cofiell R, Faas SJ, Bowdish KS. Blockade of CD200 in the presence or absence of antibody effector function: Implications for anti-CD200 therapy. J. Immunol. 180(2), 699-705 (2008
-
(2008)
J. Immunol
, vol.180
, Issue.2
, pp. 699-705
-
-
Kretz-Rommel, A.1
Qin, F.2
Dakappagari, N.3
Cofiell, R.4
Faas, S.J.5
Bowdish, K.S.6
-
146
-
-
84899475763
-
2465 First-in-human phase i dose escalation study of a humanized anti-cd200 antibody (samalizumab) in patients with advanced stage b cell chronic lymphocytic leukemia (b-cll) or multiple myeloma (mm
-
December 2010 (Abstract 2456
-
Mahadevan D, Lanasa MC, Whelden M et al. 2465 first-in-human phase i dose escalation study of a humanized anti-CD200 antibody (samalizumab) in patients with advanced stage B cell chronic lymphocytic leukemia (B-CLL) or multiple myeloma (MM). Presented at: 53rd American Society of Hematology Annual Meeting and Exposition. CA, USA, 10-13 December 2010 (Abstract 2456
-
Presented at: 53rd American Society of Hematology Annual Meeting and Exposition CA USA
, pp. 10-13
-
-
Mahadevan, D.1
Lanasa, M.C.2
Whelden, M.3
-
149
-
-
84863919927
-
Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma
-
Lonial S, Vij R, Harousseau JL et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. J. Clin. Oncol. 30(16), 1953-1959 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.16
, pp. 1953-1959
-
-
Lonial, S.1
Vij, R.2
Harousseau, J.L.3
-
150
-
-
84862672400
-
Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/ refractory multiple myeloma
-
Jakubowiak AJ, Benson DM, Bensinger W et al. Phase I trial of anti-CS1 monoclonal antibody elotuzumab in combination with bortezomib in the treatment of relapsed/ refractory multiple myeloma. J. Clin. Oncol. 30(16), 1960-1965 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.16
, pp. 1960-1965
-
-
Jakubowiak, A.J.1
Benson, D.M.2
Bensinger, W.3
-
152
-
-
80555154409
-
Computational modeling of interactions between multiple myeloma and the bone microenvironment
-
Wang Y, Pivonka P, Buenzli PR, Smith DW, Dunstan CR. Computational modeling of interactions between multiple myeloma and the bone microenvironment. PLoS ONE 6(11), e27494 (2011
-
(2011)
PLoS ONE
, vol.6
, Issue.11
-
-
Wang, Y.1
Pivonka, P.2
Buenzli, P.R.3
Smith, D.W.4
Dunstan, C.R.5
-
153
-
-
35948943113
-
Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
-
Voorhees PM, Chen Q, Kuhn DJ et al. Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Clin. Cancer Res. 13(21), 6469-6478 (2007
-
(2007)
Clin. Cancer Res
, vol.13
, Issue.21
, pp. 6469-6478
-
-
Voorhees, P.M.1
Chen, Q.2
Kuhn, D.J.3
-
154
-
-
84876196796
-
A Phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
-
Voorhees PM, Manges RF, Sonneveld P et al. A Phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 161(3), 357-366 (2013
-
(2013)
Br. J. Haematol
, vol.161
, Issue.3
, pp. 357-366
-
-
Voorhees, P.M.1
Manges, R.F.2
Sonneveld, P.3
-
155
-
-
84875243259
-
Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma
-
Suppl Abstract
-
Orlowski RZ, Gercheva L, Williams C et al. Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma. J. Clin. Oncol. 30(Suppl.), Abstract 8018 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 8018
-
-
Orlowski, R.Z.1
Gercheva, L.2
Williams, C.3
-
156
-
-
33847084044
-
Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor
-
Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT, Nishimoto N. Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor. Cancer Res. 67(3), 871-875 (2007
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 871-875
-
-
Yoshio-Hoshino, N.1
Adachi, Y.2
Aoki, C.3
Pereboev, A.4
Curiel, D.T.5
Nishimoto, N.6
-
157
-
-
50349083286
-
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
-
Malavasi F, Deaglio S, Funaro A et al. Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol. Rev. 88(3), 841-886 (2008
-
(2008)
Physiol. Rev
, vol.88
, Issue.3
, pp. 841-886
-
-
Malavasi, F.1
Deaglio, S.2
Funaro, A.3
-
158
-
-
79251570884
-
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
-
De Weers M, Tai YT, Van Der Veer MS et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J. Immunol. 186(3), 1840-1848 (2011
-
(2011)
J. Immunol
, vol.186
, Issue.3
, pp. 1840-1848
-
-
De Weers, M.1
Tai, Y.T.2
Van Der Veer, M.S.3
-
159
-
-
84878159958
-
Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma - data from a doseescalation Phase I/II Study
-
Abstract
-
Plesner T, Lokhorst H, Gimsing P, Nahi H, Lisby S, Richardson PG. Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma - data from a doseescalation Phase I/II Study. Blood 120(21), Abstract 73 (2012
-
(2012)
Blood
, vol.120
, Issue.21
, pp. 73
-
-
Plesner, T.1
Lokhorst, H.2
Gimsing, P.3
Nahi, H.4
Lisby, S.5
Richardson, P.G.6
-
162
-
-
0028337449
-
Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase
-
Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB. Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45. J. Biol. Chem. 269(25), 17238-17244 (1994
-
(1994)
CD45. J. Biol. Chem
, vol.269
, Issue.25
, pp. 17238-17244
-
-
Brown, V.K.1
Ogle, E.W.2
Burkhardt, A.L.3
Rowley, R.B.4
Bolen, J.B.5
Justement, L.B.6
-
164
-
-
34548601346
-
Radiotherapy of cd45-expressing daudi tumors in nude mice with yttrium-90-labeled pegylated anti-cd45 antibody
-
Vallera DA, Sicheneder AR, Taras EP et al. Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody. Cancer Biother. Radiopharm. 22(4), 488-500 (2007
-
(2007)
Cancer Biother. Radiopharm
, vol.22
, Issue.4
, pp. 488-500
-
-
Vallera, D.A.1
Sicheneder, A.R.2
Taras, E.P.3
-
167
-
-
79953704027
-
Copy number variations of EphA3 are associated with multiple types of hematologic malignancies
-
Guan M, Liu L, Zhao X et al. Copy number variations of EphA3 are associated with multiple types of hematologic malignancies. Clin. Lymphoma Myeloma Leuk. 11(1), 50-53 (2011
-
(2011)
Clin. Lymphoma Myeloma Leuk
, vol.11
, Issue.1
, pp. 50-53
-
-
Guan, M.1
Liu, L.2
Zhao, X.3
-
169
-
-
65549168690
-
Infusion reactions to monoclonal antibodies for solid tumors: Immunologic mechanisms and risk factors
-
Chung CH, O'Neil BH. Infusion reactions to monoclonal antibodies for solid tumors: Immunologic mechanisms and risk factors. Oncology 23(2 Suppl. 1), 14-17 (2009
-
(2009)
Oncology
, vol.23
, Issue.2 SUPPL.. 1
, pp. 14-17
-
-
Chung, C.H.1
O'Neil, B.H.2
-
170
-
-
77950517325
-
The safety and side effects of monoclonal antibodies
-
Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ. The safety and side effects of monoclonal antibodies. Nat. Rev. Drug Discov. 9(4), 325-338 (2010
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, Issue.4
, pp. 325-338
-
-
Hansel, T.T.1
Kropshofer, H.2
Singer, T.3
Mitchell, J.A.4
George, A.J.5
-
171
-
-
78650578346
-
Acute infusion reactions induced by monoclonal antibody therapy
-
Maggi E, Vultaggio A, Matucci A. Acute infusion reactions induced by monoclonal antibody therapy. Expert Rev. Clin. Immunol. 7(1), 55-63 (2011
-
(2011)
Expert Rev. Clin. Immunol
, vol.7
, Issue.1
, pp. 55-63
-
-
Maggi, E.1
Vultaggio, A.2
Matucci, A.3
-
172
-
-
40849142102
-
Cetuximab-induced anaphylaxis and IgE specific for galactose-Alpha-1,3- galactose
-
Chung CH, Mirakhur B, Chan E et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-Alpha-1,3-galactose. N. Engl. J. Med. 358(11), 1109-1117 (2008
-
(2008)
N. Engl. J. Med
, vol.358
, Issue.11
, pp. 1109-1117
-
-
Chung, C.H.1
Mirakhur, B.2
Chan, E.3
-
173
-
-
38049062199
-
Platelet-Activating factor PAF acetylhydrolase, and severe anaphylaxis
-
Vadas P, Gold M, Perelman B et al. Platelet-Activating factor, PAF acetylhydrolase, and severe anaphylaxis. N. Engl. J. Med. 358(1), 28-35 (2008
-
(2008)
N. Engl. J. Med
, vol.358
, Issue.1
, pp. 28-35
-
-
Vadas, P.1
Gold, M.2
Perelman, B.3
|