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Volumn 11, Issue 5, 2014, Pages 1159-1172

Tadalafil effect on metabolic syndrome-associated bladder alterations: An experimental study in a rabbit model

Author keywords

LUTS; Metabolic syndrome; OAB; Prostatic enlargement; Rabbit bladder; RhoA ROCK signaling; Tadalafil

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CHOLESTEROL; ESTRADIOL; RHO KINASE; TADALAFIL; TESTOSTERONE; TRIACYLGLYCEROL;

EID: 84899479024     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12478     Document Type: Article
Times cited : (23)

References (60)
  • 1
    • 0037253578 scopus 로고    scopus 로고
    • Standardisation Sub-Committee of the International Continence Society. The standardization of terminology in lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society
    • Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Van Kerrebroeck P, Victor A, Wein A. Standardisation Sub-Committee of the International Continence Society. The standardization of terminology in lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society. Urology 2003;61:37-49.
    • (2003) Urology , vol.61 , pp. 37-49
    • Abrams, P.1    Cardozo, L.2    Fall, M.3    Griffiths, D.4    Rosier, P.5    Ulmsten, U.6    Van Kerrebroeck, P.7    Victor, A.8    Wein, A.9
  • 2
    • 33644872094 scopus 로고    scopus 로고
    • A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: focus on the bladder
    • Chapple CR, Roehrborn CG. A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: focus on the bladder. Eur Urol 2006;49:651-658.
    • (2006) Eur Urol , vol.49 , pp. 651-658
    • Chapple, C.R.1    Roehrborn, C.G.2
  • 3
    • 33750617633 scopus 로고    scopus 로고
    • Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study
    • Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S, Coyne K, Kelleher C, Hampel C, Artibani W, Abrams P. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study. Eur Urol 2006;50:1306-1314.
    • (2006) Eur Urol , vol.50 , pp. 1306-1314
    • Irwin, D.E.1    Milsom, I.2    Hunskaar, S.3    Reilly, K.4    Kopp, Z.5    Herschorn, S.6    Coyne, K.7    Kelleher, C.8    Hampel, C.9    Artibani, W.10    Abrams, P.11
  • 5
    • 80052717911 scopus 로고    scopus 로고
    • Urological aspects of the metabolic syndrome
    • Hammarsten J, Peeker R. Urological aspects of the metabolic syndrome. Nat Rev Urol 2011;8:483-494.
    • (2011) Nat Rev Urol , vol.8 , pp. 483-494
    • Hammarsten, J.1    Peeker, R.2
  • 6
    • 41749114716 scopus 로고    scopus 로고
    • Birth weight, abdominal obesity and the risk of lower urinary tract symptoms in a population based study of Swedish men
    • Laven BA, Orsini N, Andersson SO, Johansson JE, Gerber GS, Wolk A. Birth weight, abdominal obesity and the risk of lower urinary tract symptoms in a population based study of Swedish men. J Urol 2008;179:1891-1895.
    • (2008) J Urol , vol.179 , pp. 1891-1895
    • Laven, B.A.1    Orsini, N.2    Andersson, S.O.3    Johansson, J.E.4    Gerber, G.S.5    Wolk, A.6
  • 7
    • 4544319602 scopus 로고    scopus 로고
    • Association of hypertension with symptoms of benign prostatic hyperplasia
    • Michel MC, Heemann U, Schumacher H, Mehlburger L, Goepel M. Association of hypertension with symptoms of benign prostatic hyperplasia. J Urol 2004;172:1390-1393.
    • (2004) J Urol , vol.172 , pp. 1390-1393
    • Michel, M.C.1    Heemann, U.2    Schumacher, H.3    Mehlburger, L.4    Goepel, M.5
  • 8
    • 0034080050 scopus 로고    scopus 로고
    • Effect of diabetes on lower urinary tract symptoms in patients with benign prostatic hyperplasia
    • Michel MC, Mehlburger L, Schumacher H, Bressel HU, Goepel M. Effect of diabetes on lower urinary tract symptoms in patients with benign prostatic hyperplasia. J Urol 2000;163:1725-1729.
    • (2000) J Urol , vol.163 , pp. 1725-1729
    • Michel, M.C.1    Mehlburger, L.2    Schumacher, H.3    Bressel, H.U.4    Goepel, M.5
  • 9
    • 65449182729 scopus 로고    scopus 로고
    • Lower urinary tract symptoms in relation to lifestyle and medical conditions in Japanese workers
    • Tomita K, Mizoue T, Matsumoto T. Lower urinary tract symptoms in relation to lifestyle and medical conditions in Japanese workers. Int J Urol 2009;16:493-498.
    • (2009) Int J Urol , vol.16 , pp. 493-498
    • Tomita, K.1    Mizoue, T.2    Matsumoto, T.3
  • 10
    • 79953025070 scopus 로고    scopus 로고
    • Members of the Florey Adelaide Male Ageing Study. Prevalence and factors associated with uncomplicated storage and voiding lower urinary tract symptoms in community-dwelling Australian men
    • Martin SA, Haren MT, Marshall VR, Lange K, Wittert GA. Members of the Florey Adelaide Male Ageing Study. Prevalence and factors associated with uncomplicated storage and voiding lower urinary tract symptoms in community-dwelling Australian men. World J Urol 2011;29:179-184.
    • (2011) World J Urol , vol.29 , pp. 179-184
    • Martin, S.A.1    Haren, M.T.2    Marshall, V.R.3    Lange, K.4    Wittert, G.A.5
  • 14
    • 77953580285 scopus 로고    scopus 로고
    • Genetics and the lower urinary tract
    • Norton P, Milsom I. Genetics and the lower urinary tract. Neurourol Urodyn 2010;29:609-611.
    • (2010) Neurourol Urodyn , vol.29 , pp. 609-611
    • Norton, P.1    Milsom, I.2
  • 15
    • 34547612993 scopus 로고    scopus 로고
    • An animal model to study lower urinary tract symptoms and erectile dysfunction: The hyperlipidaemic rat
    • Rahman NU, Phonsombat S, Bochinski D, Carrion RE, Nunes L, Lue TF. An animal model to study lower urinary tract symptoms and erectile dysfunction: The hyperlipidaemic rat. BJU Int 2007;100:658-663.
    • (2007) BJU Int , vol.100 , pp. 658-663
    • Rahman, N.U.1    Phonsombat, S.2    Bochinski, D.3    Carrion, R.E.4    Nunes, L.5    Lue, T.F.6
  • 16
    • 0032850118 scopus 로고    scopus 로고
    • Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit
    • Azadzoi KM, Tarcan T, Siroky MB, Krane RJ. Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit. J Urol 1999;161:1626-1635.
    • (1999) J Urol , vol.161 , pp. 1626-1635
    • Azadzoi, K.M.1    Tarcan, T.2    Siroky, M.B.3    Krane, R.J.4
  • 17
    • 34548414580 scopus 로고    scopus 로고
    • Alterations of M 2,3 -Muscarinic Receptor Protein and mRNA Expression in the Bladder of the Fructose Fed Obese Rat
    • Tong YC, Cheng JT. Alterations of M 2, 3 -Muscarinic Receptor Protein and mRNA Expression in the Bladder of the Fructose Fed Obese Rat. Urology 2007;178:1537-1542.
    • (2007) Urology , vol.178 , pp. 1537-1542
    • Tong, Y.C.1    Cheng, J.T.2
  • 18
    • 0032692814 scopus 로고    scopus 로고
    • Alterations in M2-muscarinic receptor protein and mRNA in diabetic rat urinary bladders
    • Tong YC, Chin WT, Cheng JT. Alterations in M2-muscarinic receptor protein and mRNA in diabetic rat urinary bladders. NeurosciLett 1999;277:173-176.
    • (1999) NeurosciLett , vol.277 , pp. 173-176
    • Tong, Y.C.1    Chin, W.T.2    Cheng, J.T.3
  • 19
    • 0036169303 scopus 로고    scopus 로고
    • Alteration of M3 subtype muscarinic receptors in the rat urinary bladder
    • Tong YC, Cheng JT. Alteration of M3 subtype muscarinic receptors in the rat urinary bladder. Pharmacology 2001;64:148-151.
    • (2001) Pharmacology , vol.64 , pp. 148-151
    • Tong, Y.C.1    Cheng, J.T.2
  • 26
    • 33846950785 scopus 로고    scopus 로고
    • BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder
    • Morelli A, Vignozzi L, Filippi S, Vannelli GB, Ambrosini S, Mancina R, Crescioli C, Donati S, Fibbi B, Colli E, Adorini L, Maggi M. BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder. Prostate 2007;67:234-247.
    • (2007) Prostate , vol.67 , pp. 234-247
    • Morelli, A.1    Vignozzi, L.2    Filippi, S.3    Vannelli, G.B.4    Ambrosini, S.5    Mancina, R.6    Crescioli, C.7    Donati, S.8    Fibbi, B.9    Colli, E.10    Adorini, L.11    Maggi, M.12
  • 27
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoidal curves: Applications to biossay, radioligand assay, and physiological dose-response curves
    • De Lean A, Munson PJ, Rodbard D. Simultaneous analysis of families of sigmoidal curves: Applications to biossay, radioligand assay, and physiological dose-response curves. Am J Physiol 1978;235:97-102.
    • (1978) Am J Physiol , vol.235 , pp. 97-102
    • De Lean, A.1    Munson, P.J.2    Rodbard, D.3
  • 28
    • 84878193974 scopus 로고    scopus 로고
    • The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation
    • Small EM. The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation. J Cardiovasc Transl Res. 2012;5:794-804.
    • (2012) J Cardiovasc Transl Res. , vol.5 , pp. 794-804
    • Small, E.M.1
  • 29
    • 14844293207 scopus 로고    scopus 로고
    • PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation
    • Zhao Z, Manser E. PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation. Biochem J 2005;386:201-214.
    • (2005) Biochem J , vol.386 , pp. 201-214
    • Zhao, Z.1    Manser, E.2
  • 30
    • 0033601250 scopus 로고    scopus 로고
    • inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase
    • Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T. inhibitory phosphorylation site for rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 1999;52:37385-37390.
    • (1999) J Biol Chem , vol.52 , pp. 37385-37390
    • Feng, J.1    Ito, M.2    Ichikawa, K.3    Isaka, N.4    Nishikawa, M.5    Hartshorne, D.J.6    Nakano, T.7
  • 31
    • 0141751697 scopus 로고    scopus 로고
    • Ca2{thorn} sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase
    • Somlyo AP, Somlyo AV. Ca2{thorn} sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325-1358.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 32
    • 9244234710 scopus 로고    scopus 로고
    • Pharmacology of the lower urinary tract: Basis for current and future treatments of urinary incontinence
    • Andersson K-E, Wein AJ. Pharmacology of the lower urinary tract: Basis for current and future treatments of urinary incontinence. Pharmacol Rev 2004;56:581-631.
    • (2004) Pharmacol Rev , vol.56 , pp. 581-631
    • Andersson, K.-E.1    Wein, A.J.2
  • 33
    • 0037352327 scopus 로고    scopus 로고
    • Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle
    • Wibberley A, Chen Z, Hu E, Hieble JP, Westfall TD. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol 2003;138:757-766.
    • (2003) Br J Pharmacol , vol.138 , pp. 757-766
    • Wibberley, A.1    Chen, Z.2    Hu, E.3    Hieble, J.P.4    Westfall, T.D.5
  • 34
    • 0347342443 scopus 로고    scopus 로고
    • Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases
    • Fleichman M, Schneider T, Fetscher C, Michel MC. Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases. J Pharmacol Exp Ther 2004;308:54-58.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 54-58
    • Fleichman, M.1    Schneider, T.2    Fetscher, C.3    Michel, M.C.4
  • 35
    • 0347342444 scopus 로고    scopus 로고
    • Signal transduction underlying carbachol-induced contraction of rat urinary bladder. I. Phospholipases and Ca2{thorn} sources
    • Schneider T, Hein P, Michel MC. Signal transduction underlying carbachol-induced contraction of rat urinary bladder. I. Phospholipases and Ca2{thorn} sources. J Pharmacol Exp Ther 2004;308:47-53.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 47-53
    • Schneider, T.1    Hein, P.2    Michel, M.C.3
  • 36
  • 37
    • 67649999446 scopus 로고    scopus 로고
    • Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat
    • Takahashi N, Shiomi H, Kushida N, etal. Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat. Neurourol Urodyn 2009;28:257-262.
    • (2009) Neurourol Urodyn , vol.28 , pp. 257-262
    • Takahashi, N.1    Shiomi, H.2    Kushida, N.3
  • 38
    • 84860490635 scopus 로고    scopus 로고
    • Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats
    • 1186 e9-1186 e14
    • Inoue S, Saito M, Takenaka A. Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats. Urology 2012;79:1186 e9-14.
    • (2012) Urology , vol.79
    • Inoue, S.1    Saito, M.2    Takenaka, A.3
  • 39
    • 70349754506 scopus 로고    scopus 로고
    • Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: An experimental rat model
    • Masago T, Watanabe T, Saito M, Kinoshita Y, Sato K, Miyagawa I. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: An experimental rat model. Int J Urol 2009;16:842-847.
    • (2009) Int J Urol , vol.16 , pp. 842-847
    • Masago, T.1    Watanabe, T.2    Saito, M.3    Kinoshita, Y.4    Sato, K.5    Miyagawa, I.6
  • 42
    • 84859422428 scopus 로고    scopus 로고
    • A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia
    • Gacci M, Corona G, Salvi M, Vignozzi L, McVary KT, Kaplan SA, Roehrborn CG, Serni S, Mirone V, Carini M, Maggi M. A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 2012;61:994-1003.
    • (2012) Eur Urol , vol.61 , pp. 994-1003
    • Gacci, M.1    Corona, G.2    Salvi, M.3    Vignozzi, L.4    McVary, K.T.5    Kaplan, S.A.6    Roehrborn, C.G.7    Serni, S.8    Mirone, V.9    Carini, M.10    Maggi, M.11
  • 43
    • 84872940957 scopus 로고    scopus 로고
    • The mechanism of action of phosphodiesterase type 5 inhibitors in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia
    • Giuliano F, Ückert S, Maggi M, Birder L, Kissel J, Viktrup L. The mechanism of action of phosphodiesterase type 5 inhibitors in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia. Eur Urol 2013;63:506-516.
    • (2013) Eur Urol , vol.63 , pp. 506-516
    • Giuliano, F.1    Ückert, S.2    Maggi, M.3    Birder, L.4    Kissel, J.5    Viktrup, L.6
  • 44
    • 84881110118 scopus 로고    scopus 로고
    • Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical studies
    • Porst H, Roehrborn CG, Secrest RJ, Esler A, Viktrup L. Effects of tadalafil on lower urinary tract symptoms secondary to benign prostatic hyperplasia and on erectile dysfunction in sexually active men with both conditions: analyses of pooled data from four randomized, placebo-controlled tadalafil clinical studies. J Sex Med 2013;10:2044-2052.
    • (2013) J Sex Med , vol.10 , pp. 2044-2052
    • Porst, H.1    Roehrborn, C.G.2    Secrest, R.J.3    Esler, A.4    Viktrup, L.5
  • 45
    • 84865750148 scopus 로고    scopus 로고
    • Tadalafil enhances the inhibitory effects of tamsulosin on neurogenic contractions of human prostate and bladder neck
    • Angulo J, Cuevas P, Fernández A, La Fuente JM, Allona A, Moncada I, Sáenz de Tejada I. Tadalafil enhances the inhibitory effects of tamsulosin on neurogenic contractions of human prostate and bladder neck. J Sex Med 2012;9:2293-2306.
    • (2012) J Sex Med , vol.9 , pp. 2293-2306
    • Angulo, J.1    Cuevas, P.2    Fernández, A.3    La Fuente, J.M.4    Allona, A.5    Moncada, I.6    Sáenz de Tejada, I.7
  • 46
    • 84855385961 scopus 로고    scopus 로고
    • Tadalafil 2.5 or 5mg administered once daily for 12 weeks in men with both erectile dysfunction and signs and symptoms of benign prostatic hyperplasia: Results of a randomized, placebo-controlled, double-blind study
    • Egerdie RB, Auerbach S, Roehrborn CG, Costa P, Garza MS, Esler AL, Wong DG, Secrest RJ. Tadalafil 2.5 or 5mg administered once daily for 12 weeks in men with both erectile dysfunction and signs and symptoms of benign prostatic hyperplasia: Results of a randomized, placebo-controlled, double-blind study. J Sex Med 2012;9:271-281.
    • (2012) J Sex Med , vol.9 , pp. 271-281
    • Egerdie, R.B.1    Auerbach, S.2    Roehrborn, C.G.3    Costa, P.4    Garza, M.S.5    Esler, A.L.6    Wong, D.G.7    Secrest, R.J.8
  • 47
    • 84899481482 scopus 로고    scopus 로고
    • Effectiveness of Tadalafil 5mg once daily in the treatment of men with lower urinary tract symptoms suggestive to benign prostatic hyperplasia with or without erectile dysfunction: Results from naturalistic observational TadaLutsEd study
    • Bechara A, Casabe A, Rodriguez Baigorri G, Cobreros C. Effectiveness of Tadalafil 5mg once daily in the treatment of men with lower urinary tract symptoms suggestive to benign prostatic hyperplasia with or without erectile dysfunction: Results from naturalistic observational TadaLutsEd study. J Sex Med 2014;11:498-505.
    • (2014) J Sex Med , vol.11 , pp. 498-505
    • Bechara, A.1    Casabe, A.2    Rodriguez Baigorri, G.3    Cobreros, C.4
  • 48
    • 84892679432 scopus 로고    scopus 로고
    • A comparative randomized prospective study to evaluate efficacy and safety of combination of tamsulosin and Tadalafil versus Tamsulosin or Tadalafil alone in patients with lower urinary tract symptoms due to benign prostatic hyperplasia
    • Singh DV, Mete UK, Mandal AK, Singh SK. A comparative randomized prospective study to evaluate efficacy and safety of combination of tamsulosin and Tadalafil versus Tamsulosin or Tadalafil alone in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. J Sex Med 2014;11:187-196.
    • (2014) J Sex Med , vol.11 , pp. 187-196
    • Singh, D.V.1    Mete, U.K.2    Mandal, A.K.3    Singh, S.K.4
  • 50
    • 79957849170 scopus 로고    scopus 로고
    • Activity of phosphodiesterase type 5 inhibitors in patients with lower urinary tract symptoms due to benign prostatic hyperplasia
    • Zhao C, Kim SH, Lee SW, Jeon JH, Kang KK, Choi SB, Park JK. Activity of phosphodiesterase type 5 inhibitors in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. Br J Urol Int 2011;107:1943-1947.
    • (2011) Br J Urol Int , vol.107 , pp. 1943-1947
    • Zhao, C.1    Kim, S.H.2    Lee, S.W.3    Jeon, J.H.4    Kang, K.K.5    Choi, S.B.6    Park, J.K.7
  • 52
    • 80053566810 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats
    • Morelli A, Sarchielli E, Comeglio P, Filippi S, Mancina R, Gacci M, Vignozzi L, Carini M, Vannelli GB, Maggi M. Phosphodiesterase type 5 expression in human and rat lower urinary tract tissues and the effect of tadalafil on prostate gland oxygenation in spontaneously hypertensive rats. J Sex Med 2011;8:2746-2760.
    • (2011) J Sex Med , vol.8 , pp. 2746-2760
    • Morelli, A.1    Sarchielli, E.2    Comeglio, P.3    Filippi, S.4    Mancina, R.5    Gacci, M.6    Vignozzi, L.7    Carini, M.8    Vannelli, G.B.9    Maggi, M.10
  • 59
    • 0024449589 scopus 로고
    • The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells
    • Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ, Gill DM. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J 1989;8:1087-1092.
    • (1989) EMBO J , vol.8 , pp. 1087-1092
    • Chardin, P.1    Boquet, P.2    Madaule, P.3    Popoff, M.R.4    Rubin, E.J.5    Gill, D.M.6
  • 60
    • 84866128524 scopus 로고    scopus 로고
    • Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways
    • Liu XM, Peyton KJ, Wang X, Durante W. Sildenafil stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells via distinct signaling pathways. Biochem Pharmacol 2012;84:1045-1054.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1045-1054
    • Liu, X.M.1    Peyton, K.J.2    Wang, X.3    Durante, W.4


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