Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: An experimental rat model: Original Article

International Journal of Urology

Volumn 16, Issue 10, 2009, Pages 842-847

  Masago, Toshihiko ^a   Watanabe, Takeshi ^a   Saito, Motoaki ^a   Kinoshita, Yukako ^a   Sato, Keisuke ^a   Miyagawa, Ikuo ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Bladder overactivity; Chemical cystitis; Hydroxyfasudil; Rat; Rho kinase inhibitor

Indexed keywords

CARBACHOL; CYCLOPHOSPHAMIDE; HYDROXYFASUDIL; RHO KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYSTOMETRY; DRUG EFFECT; DRUG INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MICTURITION; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; URINARY BLADDER, OVERACTIVE;

EID: 70349754506     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2009.02375.x     Document Type: Article

References (23)

1. Fall M, Oberpenning F, Peeker R. Treatment of bladder pain syndrome/interstitial cystitis 2008: can we make evidence-based decisions? Eur. Urol. 2008 54 : 65 75.
2. Mahadevan R, Neal M. Rho-kinase inhibition suppresses potassium chloride-induced bladder hyperactivity in a rat model. Urology 2007 69 : 791 794.
3. Rajasekaran M, Wilkens N, Kuntz S, Albo ME. Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats. Neurourol. Urodyn. 2005 24 : 295 300.
4. Christ GJ, Andersson KE. Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Neurourol. Urodyn. 2007 26 : 948 954.
5. Peters SL, Schmidt M, Michel MC. Rho kinase: a target for treating urinary bladder dysfunction? Trends Pharmacol. Sci. 2006 27 : 492 497.
6. Kamai T, Arai K, Sumi S et al. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. BJU Int. 2002 89 : 449 453.
7. Hidaka T, Suzuki Y, Yamashita M et al. Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am. J. Pathol. 2008 172 : 603 614.
8. Bokoch GM. Regulation of innate immunity by Rho GTPases. Trends Cell Biol. 2005 15 : 161 173.
9. Kageyama A, Fujino T, Taki Y et al. Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neurosci. Lett. 2008 436 : 81 4.
10. Chuang YC, Yoshimura N, Huang CC, Wu M, Chiang PH, Chancellor MB. Intravesical botulinum toxin A administration inhibits COX-2 and EP4 expression and suppresses bladder hyperactivity in cyclophosphamide-induced cystitis in rats. Eur. Urol. 2009 56 : 159 167.
11. Watanabe T, Miyagawa I. Effects of long-chain fatty alcohol on peripheral nerve conduction and bladder function in diabetic rats. Life Sci. 2002 29 : 2215 2224.
12. Saito M, Kinoshita Y, Satoh I et al. Ability of cyclohexenonic long-chain fatty alcohol to reverse diabetes-induced cystopathy in the rat. Eur. Urol. 2007 51 : 479 487.
13. Asano T, Suzuki T, Tsuchiya M et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 1989 98 : 1091 1100.
14. Rees RW, Foxowell NA, Ralph DJ, Kell PD, Moncada S, Celleck S. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J. Urol. 2003 170 : 2517 2522.
15. Teixeira CE, Jin L, Priviero FB, Ying Z, Webb RC. Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract. Biochem. Pharmacol. 2007 74 : 647 658.
16. Speich JE, Borgsmiller L, Call C, Mohr R, Ratz PH. ROK-induced cross-link formation stiffens passive muscle: reversible strain-induced stress softening in rabbit detrusor. Am. J. Physiol. Cell Physiol. 2005 289 : C12 21.
17. Wibberley A, Chen Z, Hu E, Hieble JP, Westfall TD. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br. J. Pharmacol. 2003 138 : 757 766.
18. Nakanishi K, Kamai T, Mizuno T, Arai K, Yamanishi T. Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a rho-kinase inhibitor on contraction of the porcine urinary bladder. Neurourol. Urodyn. 2009 28 : 521 528.
19. Eika B, Levin RM, Longhurst PA. Comparison of urinary bladder function in rats with hereditary diabetes insipidus, streptozotocin-induced diabetes mellitus, and nondiabetic osmotic diuresis. J. Urol. 1994 151 : 496 502.
20. Masuda H, Ogawa T, Kihara K, Chancellor MB, de Groat WC, Yoshimura N. Effects of anaesthesia on the nitrergic pathway during the micturition reflex in rats. BJU Int. 2007 100 : 175 180.
21. Andersson KE. Overactive bladder - pharmacological aspects. Scand. J. Urol. Nephrol. Suppl. 2002 210 : 72 81.
22. Souza-Fiho MV, Lima MV, Pompeu MM, Ballejo G, Cunha FQ, Ribeiro Rde A. Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Am. J. Pathol. 1997 150 : 247 256.
23. Takahashi N, Shiomi H, Kushida N et al. Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat. Neurourol. Urodyn. 2009 28 : 257 262.