Acetylation of cyclin-dependent kinase 5 is mediated by GCN5

Biochemical and Biophysical Research Communications

Volumn 447, Issue 1, 2014, Pages 121-127

  Lee, Juhyung ^a   Yun, Nuri ^a   Kim, Chiho ^a   Song, Min Young ^b   Park, Kang Sik ^b   Oh, Young J ^a  

^a Yonsei University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

Acetylation; ATP; CDK5; GCN5; K33

Indexed keywords

ACYLTRANSFERASE; CYCLIN DEPENDENT KINASE 5; HISTONE ACETYLTRANSFERASE GCN5;

ARTICLE; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; ENZYME SPECIFICITY; HISTONE ACETYLATION; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN PROCESSING;

ACETYLATION; ATP; CDK5; GCN5; K33;

ACETYLATION; CYCLIN-DEPENDENT KINASE 5; HEK293 CELLS; HISTONE ACETYLTRANSFERASES; HUMANS; LYSINE; P300-CBP TRANSCRIPTION FACTORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY;

EID: 84899477325     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.118     Document Type: Article

References (39)

1. Z.H. Cheung, A.K. Fu, and N.Y. Ip Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases Neuron 50 2006 13 18
2. Z.H. Cheung, and N.Y. Ip Cdk5: mediator of neuronal death and survival Neurosci. Lett. 361 2004 47 51
3. R. Dhavan, and L.H. Tsai A decade of CDK5 Nat. Rev. Mol. Cell Biol. 2 2001 749 759
4. P. Paoletti, I. Vila, M. Rife, J.M. Lizcano, J. Alberch, and S. Gines Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5 J. Neurosci. 28 2008 10090 10101
5. S.C. Su, and L.H. Tsai Cyclin-dependent kinases in brain development and disease Annu. Rev. Cell Dev. Biol. 27 2011 465 491
6. M.J. O'Hare, N. Kushwaha, Y. Zhang, H. Aleyasin, S.M. Callaghan, R.S. Slack, P.R. Albert, I. Vincent, and D.S. Park Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death J. Neurosci. 25 2005 8954 8966
7. T. Saito, T. Konno, T. Hosokawa, A. Asada, K. Ishiguro, and S. Hisanaga p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons J. Neurochem. 102 2007 133 140
8. W.Y. Fu, Y. Chen, M. Sahin, X.S. Zhao, L. Shi, J.B. Bikoff, K.O. Lai, W.H. Yung, A.K. Fu, M.E. Greenberg, and N.Y. Ip Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism Nat. Neurosci. 10 2007 67 76
9. I. Matsuura, and J.H. Wang Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus J. Biol. Chem. 271 1996 5443 5450
10. Y. Sasaki, C. Cheng, Y. Uchida, O. Nakajima, T. Ohshima, T. Yagi, M. Taniguchi, T. Nakayama, R. Kishida, Y. Kudo, S. Ohno, F. Nakamura, and Y. Goshima Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex Neuron 35 2002 907 920
11. L.R. Zukerberg, G.N. Patrick, M. Nikolic, S. Humbert, C.L. Wu, L.M. Lanier, F.B. Gertler, M. Vidal, R.A. Van Etten, and L.H. Tsai Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth Neuron 26 2000 633 646
12. J. Rosales, B. Han, and K.Y. Lee Cdk7 functions as a cdk5 activating kinase in brain Cell. Physiol. Biochem. 13 2003 285 296
13. J. Qu, T. Nakamura, G. Cao, E.A. Holland, S.R. McKercher, and S.A. Lipton S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide Proc. Natl. Acad. Sci. U.S.A. 108 2011 14330 14335
14. H. Iwabata, M. Yoshida, and Y. Komatsu Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies Proteomics 5 2005 4653 4664
15. S.C. Kim, R. Sprung, Y. Chen, Y. Xu, H. Ball, J. Pei, T. Cheng, Y. Kho, H. Xiao, L. Xiao, N.V. Grishin, M. White, X.J. Yang, and Y. Zhao Substrate and functional diversity of lysine acetylation revealed by a proteomics survey Mol. Cell 23 2006 607 618
16. S. Spange, T. Wagner, T. Heinzel, and O.H. Kramer Acetylation of non-histone proteins modulates cellular signalling at multiple levels Int. J. Biochem. Cell Biol. 41 2009 185 198
17. J.E. Brownell, J. Zhou, T. Ranalli, R. Kobayashi, D.G. Edmondson, S.Y. Roth, and C.D. Allis Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation Cell 84 1996 843 851
18. F. Mateo, M. Vidal-Laliena, N. Canela, A. Zecchin, M. Martinez-Balbas, N. Agell, M. Giacca, M.J. Pujol, and O. Bachs The transcriptional co-activator PCAF regulates cdk2 activity Nucleic Acids Res. 37 2009 7072 7084
19. A. Sabo, M. Lusic, A. Cereseto, and M. Giacca Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription Mol. Cell. Biol. 28 2008 2201 2212
20. R. Paolinelli, R. Mendoza-Maldonado, A. Cereseto, and M. Giacca Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle Nat. Struct. Mol. Biol. 16 2009 412 420
21. J.H. Kim, A. Saraf, L. Florens, M. Washburn, and J.L. Workman Gcn5 regulates the dissociation of SWI/SNF from chromatin by acetylation of Swi2/Snf2 Genes Dev. 24 2010 2766 2771
22. T. Holmlund, M.J. Lindberg, D. Grander, and A.E. Wallberg GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia Leukemia 27 2013 578 585
23. M. Downey, B. Knight, A.A. Vashisht, C.A. Seller, J.A. Wohlschlegel, D. Shore, and D.P. Toczyski Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1 Curr. Biol. 23 2013 1638 1648
24. E. Choi, H. Choe, J. Min, J.Y. Choi, J. Kim, and H. Lee BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis EMBO J. 28 2009 2077 2089
25. S.J. Kim, Y.J. Park, I.Y. Hwang, M.B. Youdim, K.S. Park, and Y.J. Oh Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death Free Radic. Biol. Med. 53 2012 936 950
26. C. Choudhary, C. Kumar, F. Gnad, M.L. Nielsen, M. Rehman, T.C. Walther, J.V. Olsen, and M. Mann Lysine acetylation targets protein complexes and co-regulates major cellular functions Science 325 2009 834 840
27. B.T. Weinert, S.A. Wagner, H. Horn, P. Henriksen, W.R. Liu, J.V. Olsen, L.J. Jensen, and C. Choudhary Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation Sci. Signal. 4 2011 ra48
28. W. Xu, D.G. Edmondson, and S.Y. Roth Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates Mol. Cell. Biol. 18 1998 5659 5669
29. T. Yamauchi, J. Yamauchi, T. Kuwata, T. Tamura, T. Yamashita, N. Bae, H. Westphal, K. Ozato, and Y. Nakatani Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis Proc. Natl. Acad. Sci. U.S.A. 97 2000 11303 11306
30. E. Koutelou, C.L. Hirsch, and S.Y. Dent Multiple faces of the SAGA complex Curr. Opin. Cell Biol. 22 2010 374 382
31. Z. Nagy, and L. Tora Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation Oncogene 26 2007 5341 5357
32. P.D. Jeffrey, A.A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massague, and N.P. Pavletich Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex Nature 376 1995 313 320
33. S.S. Taylor, D.R. Knighton, J. Zheng, J.M. Sowadski, C.S. Gibbs, and M.J. Zoller A template for the protein kinase family Trends Biochem. Sci. 18 1993 84 89
34. V.B. Pillai, N.R. Sundaresan, S.A. Samant, D. Wolfgeher, C.M. Trivedi, and M.P. Gupta Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes Mol. Cell. Biol. 31 2011 2349 2363
35. M. Nikolic, H. Dudek, Y.T. Kwon, Y.F. Ramos, and L.H. Tsai The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation Genes Dev. 10 1996 816 825
36. Z.H. Cheung, and N.Y. Ip Cdk5: a multifaceted kinase in neurodegenerative diseases Trends Cell Biol. 22 2012 169 175
37. X. Tang, X. Wang, X. Gong, M. Tong, D. Park, Z. Xia, and Z. Mao Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2 J. Neurosci. 25 2005 4823 4834
38. B. Tian, Q. Yang, and Z. Mao Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death Nat. Cell Biol. 11 2009 211 218
39. S. Hisanaga, and R. Endo Regulation and role of cyclin-dependent kinase activity in neuronal survival and death J. Neurochem. 115 2010 1309 1321