Silencing of hepcidin enforces the apoptosis in iron-induced human cardiomyocytes

Journal of Occupational Medicine and Toxicology

Volumn 9, Issue 1, 2014, Pages

  Hsieh, Yao Peng ^a,c   Huang, Ching Hui ^a   Lee, Chia Ying ^b   Lin, Ching Yuang ^b,c,d   Chang, Chia Chu ^a,d,e  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; GATA 4; Hepcidin siRNA; Human cardiomyocytes

Indexed keywords

CASPASE 8; CASPASE 9; FERROUS ION; HEPCIDIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 4;

APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; GENE SILENCING; HEART DEATH; HEART MUSCLE CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84899463512     PISSN: None     EISSN: 17456673     Source Type: Journal    
DOI: 10.1186/1745-6673-9-11     Document Type: Article

References (44)

1. Ferric carboxymaltose in patients with heart failure and iron deficiency. Anker SD, Josep Comin C, Gerasimos F, Ronnie W, Kenneth D, Helmut D, Lüscher TF, Boris B, Waldemar B, Joanna N, Bridget-Anne K, Claudio M, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Piotr P, for the FAIR-HF Trial Investigators, N Engl J Med 2009 361 2436 2448 10.1056/NEJMoa0908355 19920054
2. HEE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice. Turoczi T, Jun L, Cordis G, Morris JE, Maulik N, Stevens RG, Das DK, Circ Res 2003 92 1240 1246 10.1161/01.RES.0000076890.59807.23 12750309
3. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Brownlie TT, Utermohlen V, Hinton PS, Haas JD, Am J Clin Nutr 2004 79 437 443 14985219
4. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: Involvement of nitric oxide synthase and protein tyrosine nitration. Dong F, Zhang X, Culver B, Chew HG Jr, Kelley RO, Ren J, Clin Sci 2005 109 277 286 10.1042/CS20040278 15877545
5. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. Krause A, Neitz S, Mägert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K, FEBS Lett 2000 480 147 150 10.1016/S0014- 5793(00)01920-7 11034317
6. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Bernard G, Mario S, Michèle S, Axel K, Sophie V, Proc Natl Acad Sci U S A 2002 99 4596 4601 10.1073/pnas.072632499 11930010
7. Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice. Viatte L, Lesbordes-Brion JC, Lou DQ, Bennoun M, Nicolas G, Kahn A, Canonne-Hergaux F, Vaulont S, Kahn A, Canonne-Hergaux F, Vaulont S, Blood 2005 105 4861 4864 10.1182/blood-2004-12-4608 15713792
8. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J, Science 2004 306 2090 2093 10.1126/science.1104742 15514116
9. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T, Pedersen BK, Ganz T, J Clin Invest 2004 113 1271 1276 10.1172/JCI200420945 15124018
10. Two to tango: regulation of mammalian iron metabolism. Hentze MW, Muckenthaler MU, Galy B, Camaschella C, Cell 2010 142 24 38 10.1016/j.cell.2010. 06.028 20603012
11. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Babitt JL, Lin HY, Am J Kidney Dis 2010 55 726 741 10.1053/j.ajkd.2009. 12.030 20189278
12. -(2009) The role of hepcidin in iron metabolism. Nemeth E, Ganz T, Acta Haematol 2009 122 78 86 10.1159/000243791 19907144
13. Anemia in heart failure: association of hepcidin levels to iron deficiency in stable outpatients. Weber CS, Beck-da-Silva L, Goldraich LA, Biolo A, Clausell N, Acta Haematol 2013 129 55 61 10.1159/000342110 23147477
14. Iron status in patients with chronic heart failure. Jankowska EA, Malyszko J, Ardehali H, Koc-Zorawska E, Banasiak W, von Haehling S, Macdougall IC, Weiss G, McMurray JJ, Anker SD, Gheorghiade M, Ponikowski P, Eur Heart J 2013 34 827 834 10.1093/eurheartj/ehs377 23178646
15. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. Molkentin JD, J Biol Chem 2000 275 38949 38952 10.1074/jbc.R000029200 11042222
16. Re-employment of developmental transcription factors in adult heart disease. Oka T, Xu J, Molkentin JD, Semin Cell Dev Biol 2007 18 117 131 10.1016/j.semcdb.2006.11.012 17161634
17. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Weiss M, Orkin S, Proc Natl Acad Sci U S A 1995 92 9623 9627 10.1073/pnas.92.21.9623 7568185
18. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M, Proc Natl Acad Sci U S A 2004 101 6975 6980 10.1073/pnas.0401833101 15100413
19. Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor. Suzuki YJ, Evans T, Life Sci 2004 74 1829 1838 10.1016/j.lfs.2003.10.002 14761664
20. Peritoneal dialysate effluent during peritonitis induces human cardiomyocytes apoptosis by regulating the expression of GATA-4 ant Bcl-2 families. Wang HH, Lin PC, Huang HJ, Lee TY, Lin CY, J Cell Physiol 2011 226 94 102 10.1002/jcp.22309 20625998
21. Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Qiangrong L, Faseb J 2006 20 800 802 16469847
22. The Bcl2 family: regulators of the cellular life-or-death switch. Cory S, Adams JM, Nat Rev Cancer 2002 2 647 656 10.1038/nrc883 12209154
23. Molecular mechanisms of apoptosis in the cardiac myocyte. Bishopric NH, Andreka P, Slepak T, Webster KA, Curr Opin Pharmacol 2001 1 141 150 10.1016/S1471-4892(01)00032-7 11714088
24. Mechanisms of caspase activation and inhibition during apoptosis. Yigong S, Mol Cell 2002 9 459 470 10.1016/S1097-2765(02)00482-3 11931755
25. Cardiac protection by preconditioning is generated via an iron-signal created by proteasomal degradation of iron proteins. Bulvik BE, Berenshtein E, Meyron-Holtz EG, Konijn AM, Chevion M, PLoS One 2012 7 48947 10.1371/journal.pone.0048947 23155431
26. Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients. Hsieh YP, Huang CH, Lee CY, Chen HL, Lin CY, Chang CC, World J Nephrol 2013 2 38 43 10.5527/wjn.v2.i2.38 24175264
27. CAPON modulates cardiac repolarization via neuronal nitric oxide synthase in the heart. Chang KC, Barth AS, Sasano T, Kizana E, Kashiwakura Y, Zhang Y, Foster DB, Marbán E, PNAS 2008 105 4477 4482 10.1073/pnas.0709118105 18337493
28. Iron induces protection and necrosis in cultured cardiomyocytes: role of reactive oxygen species and nitric oxide. Munoz JP, Chiong M, García L, Troncoso R, Toro B, Pedrozo Z, Diaz-Elizondo J, Salas D, Parra V, Núñez MT, Hidalgo C, Lavandero S, Free Radic Biol Med 2010 48 526 534 10.1016/j.freeradbiomed.2009.11.017 19969068
29. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway. Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, Lee TS, Hsu HC, Tang CH, J Immunol 2009 183 2785 2792 10.4049/jimmunol.0802826 19635908
30. Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression. Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Giacone G, Stancanelli B, Cataliotti A, Malatino LS, Kidney Int 2004 65 1492 1498 10.1111/j.1523-1755.2004.00530.x 15086493
31. Apoptosis: basic mechanisms and implications for cardiovascular disease. Haunstetter A, Izumo S, Circ Res 1998 82 1111 1129 10.1161/01.RES.82.11.1111 9633912
32. Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture. Ancey C, Corbi P, Froger J, Delwail A, Wijdenes J, Gascan H, Potreau D, Lecron JC, Cytokine 2002 18 199 205 10.1006/cyto.2002.1033 12126642
33. Function and regulation of transferrin and ferritin. Ponka P, Beaumont C, Richardson DR, Semin Hematol 1998 35 35 54 9460808
34. Ferritin: a cytoprotective antioxidant strategem of endothelium. Balla G, Jacob HS, Balla J, Rosenberg M, Nath K, Apple F, Eaton JW, Vercellotti GM, J Biol Chem 1992 267 18148 18153 1517245
35. Organ reperfusion and preservation. Jamieson RW, Friend PJ, Front Biosci 2008 13 221 235 10.2741/2672 17981540
36. Apoptosis and cardiomyopathy. Narula J, Kolodgie FD, Virmani R, Curr Opin Cardiol 2000 15 183 188 10.1097/00001573-200005000-00011 10952426
37. TNF provokes cardiomyocytes apoptosis and cardiac remodeling through activation of multiple cell death pathways. Haudek SB, Taffet GE, Schneider MD, Mann DL, J Clin Invest 2007 117 2692 2701 10.1172/JCI29134 17694177
38. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. Kang YJ, Zhou ZX, Wang GW, Buridi A, Klein JB, J Biol Chem 2000 275 13690 13698 10.1074/jbc.275.18.13690 10788488
39. Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Suzuki YJ, Cell Signal 2011 23 1094 1099 10.1016/j.cellsig.2011.02.007 21376121
40. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H, Endocrinology 2007 148 2663 2668 10.1210/en.2006-1331 17363462
41. The iron-regulatory peptide hepcidin is upregulated in the ischemic and in the remote myocardium after myocardial infarction. Simonis G, Mueller K, Schwarz P, Wiedemann S, Adler G, Strasser RH, Kulaksiz H, Peptides 2010 31 1786 1790 10.1016/j.peptides.2010.05.013 20553779
42. GATA-4 transcription factor regulates hepatic hepcidin expression Biochem. Island M-S, Faith N, Leroyer P, Brissot P, Loreal O, J 2011 437 477 482
43. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Chen Z, Chua CC, Ho YS, Hamdy RC, Chua BH, Am J Physiol Heart Circ Physiol 2001 280 2313 H2320 11299236
44. Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells. Wu Y, Wang D, Wang X, Wang Y, Ren F, Chang D, Chang Z, Jia B, Cell Physiol Biochem 2011 27 539 546 10.1159/000329955 21691071