FTO gene variant and risk of hypertension: A meta-analysis of 57,464 hypertensive cases and 41,256 controls

Metabolism: Clinical and Experimental

Volumn 63, Issue 5, 2014, Pages 633-639

  He, Dan ^a   Fu, Maosun ^a   Miao, Song ^b   Hotta, Kikuko ^c   Chandak, Giriraj R ^d   Xi, Bo ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Medical College (Jinan)   (China)

^c KYOTO UNIVERSITY   (Japan)

^d CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

FTO; Hypertension; Meta analysis; Obesity; Variant

Indexed keywords

FTO PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BODY MASS; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; ETHNICITY; FTO GENE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; META ANALYSIS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE;

FTO; HYPERTENSION; META-ANALYSIS; OBESITY; VARIANT;

ADOLESCENT; AGED; BLOOD PRESSURE; CASE-CONTROL STUDIES; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; RISK FACTORS;

EID: 84899463011     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.02.008     Document Type: Article

References (41)

1. WHO A global brief on Hypertension. World Health Organizaion Accessed at http://www.who.int/cardiovascular-diseases/publications/global-brief- hypertension/en/index.html [on 10 May 2013]
2. S.S. Lim, T. Vos, and A.D. Flaxman et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 Lancet 380 9859 2012 2224 2260
3. C. Olives, R. Myerson, and A.H. Mokdad et al. Prevalence, awareness, treatment, and control of hypertension in United States counties, 2001-2009 PLoS One 8 4 2013 e60308
4. B. Xi, Y. Liang, and K.H. Reilly et al. Trends in prevalence, awareness, treatment, and control of hypertension among Chinese adults 1991-2009 Int J Cardiol 158 2 2012 326 329
5. B. Xi, H. Cheng, and Y. Shen et al. Physical activity modifies the associations between genetic variants and hypertension in the Chinese children Atherosclerosis 225 2 2012 376 380
6. S. El Shamieh, and S. Visvikis-Siest Genetic biomarkers of hypertension and future challenges integrating epigenomics Clin Chim Acta 414 2012 259 265
7. M.J. van Rijn, A.F. Schut, and Y.S. Aulchenko et al. Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes J Hypertens 25 3 2007 565 570
8. D. Levy, G.B. Ehret, and K. Rice et al. Genome-wide association study of blood pressure and hypertension Nat Genet 41 6 2009 677 687
9. S. Padmanabhan, O. Melander, and T. Johnson et al. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension PLoS Genet 6 10 2010 e1001177
10. G.B. Ehret, P.B. Munroe, and K.M. Rice et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Nature 478 7367 2011 103 109
11. T.M. Frayling, N.J. Timpson, and M.N. Weedon et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 5826 2007 889 894
12. B. Xi, and J. Mi Genome-wide association studies of common obesity: now and future Biomed Environ Sci 26 10 2013 787 791
13. C. Liu, S. Mou, and C. Pan The FTO gene rs9939609 polymorphism predicts risk of cardiovascular disease: a systematic review and meta-analysis PLoS One 8 8 2013 e71901
14. P.M. Kearney, M. Whelton, and K. Reynolds et al. Global burden of hypertension: analysis of worldwide data Lancet 365 9455 2005 217 223
15. T.A. Kotchen Obesity-related hypertension: epidemiology, pathophysiology, and clinical management Am J Hypertens 23 11 2010 1170 1178
16. R.M. Freathy, N.J. Timpson, and D.A. Lawlor et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI Diabetes 57 5 2008 1419 1426
17. M. Sjögren, V. Lyssenko, and A. Jonsson et al. The search for putative unifying genetic factors for components of the metabolic syndrome Diabetologia 51 12 2008 2242 2251
18. Z. Pausova, C. Syme, and M. Abrahamowicz et al. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians Circ Cardiovasc Genet 2 3 2009 260 269
19. N.J. Timpson, R. Harbord, and G. Davey Smith et al. Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype Hypertension 54 1 2009 84 90
20. T. Ahmad, D.I. Chasman, and S. Mora et al. The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women Am Heart J 160 6 2010 1163 1169
21. K. Hotta, T. Kitamoto, and A. Kitamoto et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population J Hum Genet 56 9 2011 647 651
22. B. Xi, X. Zhao, and Y. Shen et al. Associations of obesity susceptibility loci with hypertension in Chinese children Int J Obes (Lond) 37 7 2013 926 930
23. R. Kumar, S. Kohli, and P. Alam et al. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension PLoS One 8 5 2013 e63934
24. G.A. Wells, B. Shea, and D. O'connell et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses Accessed at http://www.ohri.ca/programs/clinical-epidemiology/oxford.asp [on 29 November 2013]
25. J.P. Higgins, S.G. Thompson, and J.J. Deeks et al. Measuring inconsistency in meta-analyses BMJ 327 7414 2003 557 560
26. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 3 1986 177 188
27. N. Mantel, and W. Haenszel Statistical aspects of the analysis of data from retrospective studies of disease J Natl Cancer Inst 22 4 1959 719 748
28. C.B. Begg, and M. Mazumdar Operating characteristics of a rank correlation test for publication bias Biometrics 50 4 1994 1088 1101
29. M. Egger, D. Davey Smith, and M. Schneider et al. Bias in meta-analysis detected by a simple, graphical test BMJ 315 7109 1997 629 634
30. A. Marcadenti, F.D. Fuchs, and U. Matte et al. Effects of FTO rs9939906 and MC4R rs17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension Cardiovasc Diabetol 12 1 2013 103
31. I. Shimaoka, K. Kamide, and M. Ohishi et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese Hypertens Res 33 3 2010 214 218
32. T.S. Beason, C.H. Bunker, and J.M. Zmuda et al. ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent Metabolism 60 5 2011 698 705
33. B. Xi, M. Zhang, and C. Wang et al. The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children Mol Biol Rep 40 2 2013 773 778
34. A.V. Ramos, L. Bastos-Rodrigues, and B.A. Resende et al. The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals BMC Med Genet 13 2012 101
35. J. Prakash, N. Srivastava, and S. Awasthi et al. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population Ann Hum Biol 38 6 2011 760 763
36. E. Wehr, N. Schweighofer, and R. Möller et al. Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome Metabolism 59 4 2010 575 580
37. V. Legry, D. Cottel, and J. Ferrières et al. Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study Metabolism 58 7 2009 971 975
38. P.G. Guyenet The sympathetic control of blood pressure Nat Rev Neurosci 7 5 2006 335 346
39. T. Gerken, C.A. Girard, and Y.C. Tung et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science 318 5855 2007 1469 1472
40. C. Church, L. Moir, and F. McMurray et al. Overexpression of Fto leads to increased food intake and results in obesity Nat Genet 42 12 2010 1086 1092
41. T. Fall, S. Hägg, and R. Mägi et al. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis PLoS Med 10 6 2013 e1001474