Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Sharabi, Oz ^a   Shirian, Jason ^a   Grossman, Moran ^b   Lebendiker, Mario ^a   Sagi, Irit ^b   Shifman, Julia ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; GELATINASE B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; TISSUE INHIBITOR OF METALLOPROTEINASE 2; MMP14 PROTEIN, HUMAN; PROTEIN BINDING; TIMP2 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; ENZYME ASSAY; ENZYME BINDING; MUTAGENESIS; MUTANT; POINT MUTATION; PREDICTION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN REFOLDING; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SUBSTITUTION; HUMANS; MATRIX METALLOPROTEINASE 14; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84899460613     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093712     Document Type: Article

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