Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase

Biochemical Pharmacology

Volumn 89, Issue 2, 2014, Pages 236-245

  Son, Joe Eun ^a   Jeong, Hyein ^a   Kim, Heejoo ^a   Kim, Yeong A ^a   Lee, Eunjung ^a   Lee, Hyong Joo ^a,c   Lee, Ki Won ^a,b,c  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Aortic smooth muscle cells; Atherosclerosis; Focal adhesion kinase; Pelargonidin

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTHOCYANIN; F ACTIN; FOCAL ADHESION KINASE; GLUCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; PELARGONIDIN; PELARGONIDIN 3 GLUCOSIDE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CYTOTOXICITY; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HEART PROTECTION; HUMAN AORTIC SMOOTH MUSCLE CELL; IMMUNOBLOTTING; IN VITRO STUDY; PRIORITY JOURNAL; REDUCTION; SMOOTH MUSCLE FIBER; SURVIVAL; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING;

AORTIC SMOOTH MUSCLE CELLS; ATHEROSCLEROSIS; FOCAL ADHESION KINASE; PELARGONIDIN; PELARGONIDIN CHLORIDE (PUBCHEM CID: 67249); PELARGONIDIN-3-O-GLUCOSIDE CHLORIDE (PUBCHEM CID: 16218556);

ANIMALS; ANTHOCYANINS; AORTA, THORACIC; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FOCAL ADHESION KINASE 1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ORGAN CULTURE TECHNIQUES; PIGMENTS, BIOLOGICAL; PROTO-ONCOGENE PROTEINS C-SIS; RATS;

EID: 84899452444     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.015     Document Type: Article

References (50)

1. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990 Nature 362 1993 801 809
2. C.K. Glass, and J.L. Witztum Atherosclerosis the road ahead Cell 104 2001 503 516
3. J.J. Fuster, P. Fernandez, H. Gonzalez-Navarro, C. Silvestre, Y.N. Nabah, and V. Andres Control of cell proliferation in atherosclerosis: insights from animal models and human studies Cardiovasc Res 86 2010 254 264
4. R. Ross Atherosclerosis - an inflammatory disease N Engl J Med 340 1999 115 126
5. E.W. Raines PDGF and cardiovascular disease Cytokine Growth Factor Rev 15 2004 237 254
6. C.H. Heldin, A. Ostman, and L. Ronnstrand Signal transduction via platelet-derived growth factor receptors Biochim Biophys Acta 1998 1378
7. A.D. Hughes, G.F. Clunn, J. Refson, and C. Demoliou-Mason Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle Gen Pharmacol 27 1996 1079 1089
8. S.K. Mitra, D.A. Hanson, and D.D. Schlaepfer Focal adhesion kinase: in command and control of cell motility Nat Rev Mol Cell Biol 6 2005 56 68
9. M.D. Schaller, J.D. Hildebrand, J.D. Shannon, J.W. Fox, R.R. Vines, and J.T. Parsons Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Mol Cell Biol 14 1994 1680 1688
10. D.J. Sieg, C.R. Hauck, D. Ilic, C.K. Klingbeil, E. Schaefer, and C.H. Damsky et al. FAK integrates growth-factor and integrin signals to promote cell migration Nat Cell Biol 2 2000 249 256
11. M.B. Calalb, T.R. Polte, and S.K. Hanks Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases Mol Cell Biol 15 1995 954 963
12. D. Ilic, B. Kovacic, S. McDonagh, F. Jin, C. Baumbusch, and D.G. Gardner et al. Focal adhesion kinase is required for blood vessel morphogenesis Circ Res 92 2003 300 307
13. Z. Cheng, L.J. Sundberg-Smith, L.E. Mangiante, R.L. Sayers, Z.S. Hakim, and S. Musunuri et al. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature Arterioscler Thromb Vasc Biol 31 2011 2193 2202
14. Y.E. Koshman, M. Chu, S.J. Engman, T. Kim, R. Iyengar, and S.L. Robia et al. Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding Arterioscler Thromb Vasc Biol 31 2011 2432 2440
15. J.M. Taylor, C.P. Mack, K. Nolan, C.P. Regan, G.K. Owens, and J.T. Parsons Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells Mol Cell Biol 21 2001 1565 1572
16. J.M. Geleijnse, L.J. Launer, D.A. Van der Kuip, A. Hofman, and J.C. Witteman Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study Am J Clin Nutr 75 2002 880 886
17. K.J. Mukamal, M. Maclure, J.E. Muller, J.B. Sherwood, and M.A. Mittleman Tea consumption and mortality after acute myocardial infarction Circulation 105 2002 2476 2481
18. Y. Surh Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances Mutat Res 428 1999 305 327
19. K.W. Lee, N.J. Kang, M.H. Oak, M.K. Hwang, J.H. Kim, and V.B. Schini-Kerth et al. Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities Cardiovasc Res 79 2008 34 41
20. X. Wu, G.R. Beecher, J.M. Holden, D.B. Haytowitz, S.E. Gebhardt, and R.L. Prior Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption J Agric Food Chem 54 2006 4069 4075
21. P. Bridle, and C. GarciaViguera Analysis of anthocyanins in strawberries and elderberries. A comparison of capillary zone electrophoresis and HPLC Food Chem 59 1997 299 304
22. M. Roghani, A. Niknam, M.R. Jalali-Nadoushan, Z. Kiasalari, M. Khalili, and T. Baluchnejadmojarad Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism Brain Res Bull 82 2010 279 283
23. M. Roy, S. Sen, and A.S. Chakraborti Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification Life Sci 82 2008 1102 1110
24. Q. Remijsen, T. Vanden Berghe, E. Wirawan, B. Asselbergh, E. Parthoens, and R. De Rycke et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation Cell Res 21 2011 290 304
25. K.H. Choi, J.E. Kim, N.R. Song, J.E. Son, M.K. Hwang, and S. Byun et al. Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells Cardiovasc Res 85 2010 836 844
26. C.K. Lee, H.M. Lee, H.J. Kim, H.J. Park, K.J. Won, and H.Y. Roh et al. Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways Cardiovasc Res 74 2007 159 168
27. H.M. Lee, B.H. Jeon, K.J. Won, C.K. Lee, T.K. Park, and W.S. Choi et al. Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway Circ Res 104 2009 219 227 5p following 27
28. S. Byun, K.W. Lee, S.K. Jung, E.J. Lee, M.K. Hwang, and S.H. Lim et al. Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer Cancer Res 70 2010 2415 2423
29. N.O. Carragher, and M.C. Frame Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion Trends Cell Biol 14 2004 241 249
30. J.K. Slack-Davis, K.H. Martin, R.W. Tilghman, M. Iwanicki, E.J. Ung, and C. Autry et al. Cellular characterization of a novel focal adhesion kinase inhibitor J Biol Chem 282 2007 14845 14852
31. R. Braren, H. Hu, Y.H. Kim, H.E. Beggs, L.F. Reichardt, and R. Wang Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation J Cell Biol 172 2006 151 162
32. J. Davignon, and P. Ganz Role of endothelial dysfunction in atherosclerosis Circulation 109 2004 III27 III32
33. V. Hong, and R.E. Wrolstad Characterization of anthocyanin-containing colorants and fruit juices by hplc photodiode array detection J Agric Food Chem 38 1990 698 708
34. J.M. Koponen, A.M. Happonen, P.H. Mattila, and A.R. Torronen Contents of anthocyanins and ellagitannins in selected foods consumed in Finland J Agric Food Chem 55 2007 1612 1619
35. Y. Noda, T. Kaneyuki, A. Mori, and L. Packer Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin J Agric Food Chem 50 2002 166 171
36. K. Nemeth, G.W. Plumb, J.G. Berrin, N. Juge, R. Jacob, and H.Y. Naim et al. Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Eur J Nutr 42 2003 29 42
37. N.M. Hassimotto, M.I. Genovese, and F.M. Lajolo Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats Nutr Res 28 2008 198 207
38. K. Keppler, and H.U. Humpf Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora Bioorg Med Chem 13 2005 5195 5205
39. N.R. Song, H. Yang, J. Park, J.Y. Kwon, N.J. Kang, and Y.S. Heo et al. Cyanidin suppresses neoplastic cell transformation by directly targeting phosphatidylinositol 3-kinase Food Chem 133 2012 658 664
40. K. Briviba, S.L. Abrahamse, B.L. Pool-Zobel, and G. Rechkemmer Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides Nutr Cancer 41 2001 172 179
41. K.W. Lee, A.M. Bode, and Z. Dong Molecular targets of phytochemicals for cancer prevention Nat Rev Cancer 11 2011 211 218
42. D.D. Schlaepfer, and S.K. Mitra Multiple connections link FAK to cell motility and invasion Curr Opin Genet Dev 14 2004 92 101
43. S.N. Hochwald, C. Nyberg, M. Zheng, D. Zheng, C. Wood, and N.A. Massoll et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer Cell Cycle 8 2009 2435 2443
44. J. Halder, Y.G. Lin, W.M. Merritt, W.A. Spannuth, A.M. Nick, and T. Honda et al. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma Cancer Res 67 2007 10976 10983
45. M.A. Cabrita, L.M. Jones, J.L. Quizi, L.A. Sabourin, B.C. McKay, and C.L. Addison Focal adhesion kinase inhibitors are potent anti-angiogenic agents Mol Oncol 5 2011 517 526
46. R.L. Sayers, L.J. Sundberg-Smith, M. Rojas, H. Hayasaka, J.T. Parsons, and C.P. Mack et al. FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury Arterioscler Thromb Vasc Biol 28 2008 2115 2122
47. B. Tavora, S. Batista, L.E. Reynolds, S. Jadeja, S. Robinson, and V. Kostourou et al. Endothelial FAK is required for tumour angiogenesis EMBO Mol Med 2 2010 516 528
48. T.L. Shen, A.Y. Park, A. Alcaraz, X. Peng, I. Jang, and P. Koni et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis J Cell Biol 169 2005 941 952
49. S.M. Short, G.A. Talbott, and R.L. Juliano Integrin-mediated signaling events in human endothelial cells Mol Biol Cell 9 1998 1969 1980
50. N.J. Kang, S.H. Shin, H.J. Lee, and K.W. Lee Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis Pharmacol. Ther. 130 2011 310 324