Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 5, 2014, Pages 1365-1372

  Johnson, Teresa L ^a   Gaddini, Gino ^a   Branscum, Adam J ^a   Olson, Dawn A ^a   Caroline Westerlind, Kim ^b   Turner, Russell T ^a   Iwaniec, Urszula T ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Densitometry; Ethanol; Microcomputed tomography; Rat model; Wheel running

Indexed keywords

ALCOHOL;

ANATOMY AND HISTOLOGY; ANIMAL; ANIMAL EXPERIMENT; BONE; BONE DENSITY; DRUG EFFECTS; FEMUR; MALE; MICRO-COMPUTED TOMOGRAPHY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; VERTEBRA;

ABSORPTIOMETRY, PHOTON; ANIMALS; BONE AND BONES; BONE DENSITY; ETHANOL; FEMUR; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; THORACIC VERTEBRAE; X-RAY MICROTOMOGRAPHY;

EID: 84899428150     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12366     Document Type: Article

References (51)

1. Armas LA, Recker RR (2012) Pathophysiology of osteoporosis: new mechanistic insights. Endocrinol Metab Clin North Am 41:475-486.
2. Barrack MT, Van Loan MD, Rauh MJ, Nichols JF (2011) Body mass, training, menses, and bone in adolescent runners: a 3-yr follow-up. Med Sci Sports Exerc 43:959-966.
3. Bennell KL, Malcolm SA, Thomas SA, Reid SJ, Brukner PD, Ebeling PR, Wark JD (1996a) Risk factors for stress fractures in track and field athletes. A twelve-month prospective study. Am J Sports Med 24:810-818.
4. Bennell KL, Malcolm SA, Thomas SA, Wark JD, Brukner PD (1996b) The incidence and distribution of stress fractures in competitive track and field athletes. A twelve-month prospective study. Am J Sports Med 24:211-217.
5. Berg KM, Kunins HV, Jackson JL, Nahvi S, Chaudhry A, Harris KA Jr, Malik R, Arnsten JH (2008) Association between alcohol consumption and both osteoporotic fracture and bone density. Am J Med 121:406-418.
6. Beyer RE, Huang JC, Wilshire GB (1985) The effect of endurance exercise on bone dimensions, collagen, and calcium in the aged male rat. Exp Gerontol 20:315-323.
7. Bourrin S, Genty C, Palle S, Gharib C, Alexandre C (1994) Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat. J Appl Physiol 76:1999-2005.
8. Bray RM, Pemberton MR, Lane ME, Hourani LL, Mattiko MJ, Babeu LA (2010) Substance use and mental health trends among U.S. military active duty personnel: key findings from the 2008 DoD Health Behavior Survey. Mil Med 175:390-399.
9. Burr DB, Turner CH, Naick P, Forwood MR, Ambrosius W, Hasan MS, Pidaparti R (1998) Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31:337-345.
10. Carter DR, Hayes WC (1977) Compact bone fatigue damage: a microscopic examination. Clin Orthop Relat Res 127:265-274.
11. Chappard D, Plantard B, Petitjean M, Alexandre C, Riffat G (1991) Alcoholic cirrhosis and osteoporosis in men: a light and scanning electron microscopy study. J Stud Alcohol 52:269-274.
12. Frost HM (1988) Vital biomechanics: proposed general concepts for skeletal adaptations to mechanical usage. Calcif Tissue Int 42:145-156.
13. Fuchs RK, Bauer JJ, Snow CM (2001) Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res 16:148-156.
14. Giuliani N, Girasole G, Vescovi PP, Passeri G, Pedrazzoni M (1999) Ethanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow cultures. Alcohol Clin Exp Res 23:381-385.
15. Hogan HA, Groves JA, Sampson HW (1999) Long-term alcohol consumption in the rat affects femur cross-sectional geometry and bone tissue material properties. Alcohol Clin Exp Res 23:1825-1833.
16. Holbrook TL, Barrett-Connor E (1993) A prospective study of alcohol consumption and bone mineral density. BMJ 306:1506-1509.
17. Iwaniec UT, Turner RT (2008) Animal models for osteoporosis, in Osteoporosis, Vol. 2 (Marcus R ed), pp 985-1009. Elsevier, Amsterdam.
18. Keyes KM, Grant BF, Hasin DS (2008) Evidence for a closing gender gap in alcohol use, abuse, and dependence in the United States population. Drug Alcohol Depend 93:21-29.
19. Kiuru MJ, Niva M, Reponen A, Pihlajamaki HK (2005) Bone stress injuries in asymptomatic elite recruits: a clinical and magnetic resonance imaging study. Am J Sports Med 33:272-276.
20. Leichter J, Lee M (1982) Method of ethanol administration as a confounding factor in studies of fetal alcohol syndrome. Life Sci 31:221-227.
21. Lieber CS, DeCarli LM (1982) The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol Clin Exp Res 6:523-531.
22. Maddalozzo GF, Turner RT, Edwards CH, Howe KS, Widrick JJ, Rosen CJ, Iwaniec UT (2009) Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats. Osteoporos Int 20:1529-1538.
23. Malik P, Gasser RW, Kemmler G, Moncayo R, Finkenstedt G, Kurz M, Fleischhacker WW (2009) Low bone mineral density and impaired bone metabolism in young alcoholic patients without liver cirrhosis: a cross-sectional study. Alcohol Clin Exp Res 33:375-381.
24. Marrone JA, Maddalozzo GF, Branscum AJ, Hardin K, Cialdella-Kam L, Philbrick KA, Breggia AC, Rosen CJ, Turner RT, Iwaniec UT (2012) Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause 19:974-979.
25. Martin EA, Ritman EL, Turner RT (2003) Time course of epiphyseal growth plate fusion in rat tibiae. Bone 32:261-267.
26. Mattila VM, Niva M, Kiuru M, Pihlajamaki H (2007) Risk factors for bone stress injuries: a follow-up study of 102, 515 person-years. Med Sci Sports Exerc 39:1061-1066.
27. Maurel DB, Boisseau N, Benhamou CL, Jaffre C (2012) Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int 23:1-16.
28. Maurel DB, Boisseau N, Pallu S, Rochefort GY, Benhamou CL, Jaffre C (2013) Regular exercise limits alcohol effects on trabecular, cortical thickness and porosity, and osteocyte apoptosis in the rat. Joint Bone Spine 80:492-498.
29. McColl DJ, Abel RL, Spears IR, Macho GA (2006) Automated method to measure trabecular thickness from microcomputed tomographic scans and its application. Anat Rec A Discov Mol Cell Evol Biol 288:982-988.
30. Nielsen SJ, Kit BK, Fakhouri T, Ogden CL (2012) Calories consumed from alcoholic beverages by U.S. adults, 2007-2010. NCHS Data Brief 110:1-8.
31. Niva MH, Kiuru MJ, Haataja R, Pihlajamaki HK (2005) Fatigue injuries of the femur. J Bone Joint Surg Br 87:1385-1390.
32. Nyquist F, Duppe H, Obrant KJ, Bondeson L, Nordsletten L (2002) Effects of alcohol on bone mineral and mechanical properties of bone in male rats. Alcohol 37:21-24.
33. Pasco JA, Lane SE, Brennan SL, Timney EN, Bucki-Smith G, Dobbins AG, Nicholson GC, Kotowicz MA (2013) Fracture risk among older men: osteopenia and osteoporosis defined using cut-points derived from female versus male reference data. Osteoporos Int [Epub ahead of print].
34. Piano MR, Artwohl J, Kim SD, Gass G (2001) The effects of a liquid ethanol diet on nutritional status and fluid balance in the rat. Alcohol 36:298-303.
35. R Development Core Team (2010) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available at: http://www.R-project.org/. Accessed January 29, 2014.
36. Reed AH, McCarty HL, Evans GL, Turner RT, Westerlind KC (2002) The effects of chronic alcohol consumption and exercise on the skeleton of adult male rats. Alcohol Clin Exp Res 26:1269-1274.
37. Sampson HW (1998) Effect of alcohol consumption on adult and aged bone: a histomorphometric study of the rat animal model. Alcohol Clin Exp Res 22:2029-2034.
38. Scofield KL, Hecht S (2012) Bone health in endurance athletes: runners, cyclists, and swimmers. Curr Sports Med Rep 11:328-334.
39. Sibonga JD, Iwaniec UT, Shogren KL, Rosen CJ, Turner RT (2007) Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse. Bone 40:1013-1020.
40. Tai K, Pelled G, Sheyn D, Bershteyn A, Han L, Kallai I, Zilberman Y, Ortiz C, Gazit D (2008) Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells. Tissue Eng Part A 14:1709-1720.
41. Trevisiol CH, Turner RT, Pfaff JE, Hunter JC, Menagh PJ, Hardin K, Ho E, Iwaniec UT (2007) Impaired osteoinduction in a rat model for chronic alcohol abuse. Bone 41:175-180.
42. Turner RT, Doran E, Iwaniec UT (2012) Detrimental Effects of Alcohol on Bone Growth, in Osteogenesis (Lin Y ed), pp 57-82. InTech, Rijeka, Croatia.
43. Turner RT, Kidder LS, Kennedy A, Evans GL, Sibonga JD (2001) Moderate alcohol consumption suppresses bone turnover in adult female rats. J Bone Miner Res 16:589-594.
44. Turner RT, Rosen CJ, Iwaniec UT (2010) Effects of alcohol on skeletal response to growth hormone in hypophysectomized rats. Bone 46:806-812.
45. Turner RT, Wronski TJ, Zhang M, Kidder LS, Bloomfield SA, Sibonga JD (1998) Effects of ethanol on gene expression in rat bone: transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation. Alcohol Clin Exp Res 22:1591-1599.
46. U.S. Department of Agriculture and U.S. Department of Health and Human Services (2010) Dietary Guidelines for Americans, 2010. 7th ed. U.S. Government Printing Office, Washington, DC.
47. de Vernejoul MC, Bielakoff J, Herve M, Gueris J, Hott M, Modrowski D, Kuntz D, Miravet L, Ryckewaert A (1983) Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men. Clin Orthop Relat Res 179:107-115.
48. Vignesh RC, Sitta Djody S, Jayasudha E, Gopalakrishnan V, Ilangovan R, Balaganesh M, Veni S, Sridhar M, Srinivasan N (2006) Effect of ethanol on human osteosarcoma cell proliferation, differentiation and mineralization. Toxicology 220:63-70.
49. Wakley GK, Portwood JS, Turner RT (1992) Disuse osteopenia is accompanied by downregulation of gene expression for bone proteins in growing rats. Am J Physiol 263:E1029-E1034.
50. Wheeler DL, Graves JE, Miller GJ, Vander Griend RE, Wronski TJ, Powers SK, Park HM (1995) Effects of running on the torsional strength, morphometry, and bone mass of the rat skeleton. Med Sci Sports Exerc 27:520-529.
51. Yusko DA, Buckman JF, White HR, Pandina RJ (2008) Risk for excessive alcohol use and drinking-related problems in college student athletes. Addict Behav 33:1546-1556.