Effects of alcohol on skeletal response to growth hormone in hypophysectomized rats

Bone

Volumn 46, Issue 3, 2010, Pages 806-812

  Turner, Russell T ^a   Rosen, Clifford J ^b,c   Iwaniec, Urszula T ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b ST JOSEPH HOSPITAL   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

Bone histomorphometry; Hypophysectomy; IGF I; Osteoblast; Osteoporosis

Indexed keywords

ALCOHOL; GROWTH HORMONE; SOMATOMEDIN C;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE METABOLISM; BONE MINERALIZATION; CANCELLOUS BONE; CONTROLLED STUDY; GROWTH HORMONE DEFICIENCY; GROWTH RATE; HYPOPHYSECTOMY; HYPOPHYSIS; MALE; NONHUMAN; OBESITY; RAT; SEXUAL MATURITY; TIBIA; WEIGHT GAIN; ANIMAL; BONE MARROW; BONE REMODELING; COMPARATIVE STUDY; DEFICIENCY; DRUG EFFECTS; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MARROW; BONE REMODELING; ETHANOL; GROWTH HORMONE; HYPOPHYSECTOMY; MALE; PITUITARY GLAND; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 77649188076     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.10.027     Document Type: Article

References (48)

1. Sampson H.W. Alcohol and other factors affecting osteoporosis risk in women. Alcohol Res. Health 2002, 26:292-298.
2. Turner R.T. Skeletal response to alcohol. Alcohol Clin. Exp. Res. 2000, 24:1693-1701.
3. Rapuri P.B., Gallagher J.C., Balhorn K.E., Ryschon K.L. Alcohol intake and bone metabolism in elderly women. Am. J. Clin. Nutr. 2000, 72:1206-1213.
4. Giuliani N., Girasole G., Vescovi P.P., Passeri G., Pedrazzoni M. Ethanol and acetaldehyde inhibit the formation of early osteoblast progenitors in murine and human bone marrow cultures. Alcohol Clin. Exp. Res. 1999, 23:381-385.
5. Maran A., Zhang M., Spelsberg T.C., Turner R.T. The dose-response effects of ethanol on the human fetal osteoblastic cell line. J. Bone Miner. Res. 2001, 16:270-276.
6. Vignesh R.C., Sitta Djody S., Jayasudha E., Gopalakrishnan V., Ilangovan R., Balaganesh M., et al. Effect of ethanol on human osteosarcoma cell proliferation, differentiation and mineralization. Toxicology 2006, 220:63-70.
7. Turner R.T., Kidder L.S., Kennedy A., Evans G.L., Sibonga J.D. Moderate alcohol consumption suppresses bone turnover in adult female rats. J. Bone Miner. Res. 2001, 16:589-594.
8. Dumitrescu R.G., Shields P.G. The etiology of alcohol-induced breast cancer. Alcohol 2005, 35:213-225.
9. Iwaniec U.T., Trevisiol C.H., Maddalozzo G.F., Rosen C.J., Turner R.T. Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse. Bone 2008, 42:695-701.
10. Maddalozzo G.F., Turner R.T., Edwards C.H., Howe K.S., Widrick J.J., Rosen C.J., et al. Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats. Osteoporos. Int. 2009, 20:1529-1538.
11. Ronis M.J., Wands J.R., Badger T.M., de la Monte S.M., Lang C.H., Calissendorff J. Alcohol-induced disruption of endocrine signaling. Alcohol Clin. Exp. Res. 2007, 31:1269-1285.
12. Sibonga J.D., Iwaniec U.T., Shogren K.L., Rosen C.J., Turner R.T. Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse. Bone 2007, 40:1013-1020.
13. Sampson H.W., Hebert V.A., Booe H.L., Champney T.H. Effect of alcohol consumption on adult and aged bone: composition, morphology, and hormone levels of a rat animal model. Alcohol Clin. Exp. Res. 1998, 22:1746-1753.
14. Sampson H.W., Spears H. Osteopenia due to chronic alcohol consumption by young actively growing rats is not completely reversible. Alcohol Clin. Exp. Res. 1999, 23:324-327.
15. Turner R.T., Wronski T.J., Zhang M., Kidder L.S., Bloomfield S.A., Sibonga J.D. Effects of ethanol on gene expression in rat bone: transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation. Alcohol Clin. Exp. Res. 1998, 22:1591-1599.
16. Morita Y., Iwamoto I., Mizuma N., Kuwahata T., Matsuo T., Yoshinaga M., et al. Precedence of the shift of body-fat distribution over the change in body composition after menopause. J. Obstet. Gynaecol. Res. 2006, 32:513-516.
17. Pei L., Tontonoz P. Fat's loss is bone's gain. J. Clin. Invest. 2004, 113:805-806.
18. Menagh PJ, Turner RT, Lowry MB, Wong C, Yakar S, Rosen CJ, Iwaniec UT. Growth hormone regulates the balance between bone formation and bone marrow adiposity J Bone Miner Res in press.
19. Iwaniec U.T., Wronski T.J., Turner R.T. Histological analysis of bone. Methods Mol. Biol. 2008, 447:325-341.
20. Westerlind K.C., Wronski T.J., Ritman E.L., Luo Z.P., An K.N., Bell N.H., et al. Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:4199-4204.
21. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 1987, 2:595-610.
22. Iwaniec U., Turner R. Animal models for osteoporosis. Osteoporosis 2008, 985-2009. Elsevier Press, New York. 3 ed. R. Marcus, D. Feldman, D.A. Nelson, C.J. Rosen (Eds.).
23. Kasukawa Y., Miyakoshi N., Mohan S. The anabolic effects of GH/IGF system on bone. Curr. Pharm. Des. 2004, 10:2577-2592.
24. Nilsson A., Swolin D., Enerback S., Ohlsson C. Expression of functional growth hormone receptors in cultured human osteoblast-like cells. J. Clin. Endocrinol. Metab. 1995, 80:3483-3488.
25. Ohlsson C., Bengtsson B.A., Isaksson O.G., Andreassen T.T., Slootweg M.C. Growth hormone and bone. Endocr. Rev. 1998, 19:55-79.
26. Yeh J.K., Chen M.M., Aloia J.F. Effects of estrogen and growth hormone on skeleton in the ovariectomized rat with hypophysectomy. Am. J. Physiol. 1997, 273:E734-E742.
27. Kidder L.S., Schmidt I.U., Evans G.L., Turner R.T. Effects of growth hormone and low dose estrogen on bone growth and turnover in long bones of hypophysectomized rats. Calcif. Tissue Int. 1997, 61:327-335.
28. Dobnig H., Turner R.T. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 1995, 136:3632-3638.
29. Kostenuik P.J., Harris J., Halloran B.P., Turner R.T., Morey-Holton E.R., Bikle D.D. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J. Bone Miner. Res. 1999, 14:21-31.
30. Lang C.H., Liu X., Nystrom G., Wu D., Cooney R.N., Frost R.A. Acute effects of growth hormone in alcohol-fed rats. Alcohol Alcohol 2000, 35:148-158.
31. Bikle D.D., Sakata T., Leary C., Elalieh H., Ginzinger D., Rosen C.J., et al. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J. Bone Miner. Res. 2002, 17:1570-1578.
32. Wang Y., Nishida S., Boudignon B.M., Burghardt A., Elalieh H.Z., Hamilton M.M., et al. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J. Bone Miner. Res. 2007, 22:1329-1337.
33. Mohan S., Baylink D.J. Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences. J. Endocrinol. 2005, 185:415-420.
34. Mohan S., Richman C., Guo R., Amaar Y., Donahue L.R., Wergedal J., et al. Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms. Endocrinology 2003, 144:929-936.
35. Wang J., Zhou J., Cheng C.M., Kopchick J.J., Bondy C.A. Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth. J. Endocrinol. 2004, 180:247-255.
36. Yakar S., Rosen C.J., Beamer W.G., Ackert-Bicknell C.L., Wu Y., Liu J.L., et al. Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin. Invest. 2002, 110:771-781.
37. Schmidt I.U., Dobnig H., Turner R.T. Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats. Endocrinology 1995, 136:5127-5134.
38. Turner R.T., Evans G.L., Zhang M., Sibonga J.D. Effects of parathyroid hormone on bone formation in a rat model for chronic alcohol abuse. Alcohol Clin. Exp. Res. 2001, 25:667-671.
39. Bikle D.D., Harris J., Halloran B.P., Currier P.A., Tanner S., Morey-Holton E. The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 1995, 136:2099-2109.
40. Sakata T., Halloran B.P., Elalieh H.Z., Munson S.J., Rudner L., Venton L., et al. Skeletal unloading induces resistance to insulin-like growth factor I on bone formation. Bone 2003, 32:669-680.
41. Sakata T., Wang Y., Halloran B.P., Elalieh H.Z., Cao J., Bikle D.D. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J. Bone Miner. Res. 2004, 19:436-446.
42. Ren J., Jefferson L., Sowers J.R., Brown R.A. Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats. Hypertension 1999, 34:1215-1222.
43. Hefferan T.E., Kennedy A.M., Evans G.L., Turner R.T. Disuse exaggerates the detrimental effects of alcohol on cortical bone. Alcohol Clin. Exp. Res. 2003, 27:111-117.
44. Chen J.R., Haley R.L., Hidestrand M., Shankar K., Liu X., Lumpkin C.K., et al. Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts. J. Pharmacol. Exp. Ther. 2006, 319:1182-1190.
45. Chen J.R., Lazarenko O.P., Haley R.L., Blackburn M.L., Badger T.M., Ronis M.J. Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts. J. Bone Miner. Res. 2009, 24:221-230.
46. Turner R.T., Rickard D.J., Iwaniec U.T., Speleberg T.C. Estrogens and progestins. Principles of Bone Biology 2008, 847-877. Academic Press. J.P. Bilezikian, L.G. Raisz, J. Martin (Eds.).
47. Sibonga J.D., Dobnig H., Harden R.M., Turner R.T. Effect of the high-affinity estrogen receptor ligand ICI 182,780 on the rat tibia. Endocrinology 1998, 139:3736-3742.
48. Turner R.T., Evans G.L., Dobnig H. The high-affinity estrogen receptor antagonist ICI 182,780 has no effect on bone growth in young male rats. Calcif. Tissue Int. 2000, 66:461-464.