The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions

Journal of Biological Chemistry

Volumn 289, Issue 17, 2014, Pages 12063-12076

  M̈nch, Daniela ^a   Müller, Anna ^a   Schneider, Tanja ^a   Kohl, Bastian ^b   Wenzel, Michaela ^b   Bandow, Julia Elisabeth ^b   Maffioli, Sonia ^c   Sosio, Margherita ^c   Donadio, Stefano ^c   Wimmer, Reinhard ^d   Sahl, Hans Georg ^a  

^a UNIVERSITY OF BONN   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c NAICONS Srl   (Italy)

^d AALBORG UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MACHINERY;

BACTERIAL MEMBRANES; CELL ENVELOPES; CELL WALL BIOSYNTHESIS; CELL WALLS; DUAL MECHANISMS; LANTIBIOTICS; MEMBRANE FUNCTIONS; MODE OF ACTION;

BIOCHEMISTRY;

BACTERIAL ENZYME; BACTOPRENOL; FEMX PROTEIN; LANTIBIOTIC; LIPID; MRAY PROTEIN; MURG PROTEIN; NAI 107; NISIN; PBP2 PROTEIN; PYROPHOSPHATE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID; VANCOMYCIN;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL WALL; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BIOSYNTHESIS; CELL MEMBRANE DEPOLARIZATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DRUG BINDING; DRUG DETERMINATION; DRUG POTENCY; DRUG TARGETING; ENZYME PURIFICATION; ENZYME SUBSTRATE; IN VITRO STUDY; MICROCOCCUS LUTEUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS SIMULANS; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; TITRIMETRY;

ANTIBIOTICS; CELL WALL; LANTIBIOTICS; LIPID II; MEMBRANE; NISIN; NUCLEAR MAGNETIC RESONANCE; PEPTIDOGLYCAN; STAPHYLOCOCCUS AUREUS; TEICHOIC ACID;

AMINO ACID SEQUENCE; BACTERIOCINS; CELL WALL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEOMICS; STAPHYLOCOCCUS AUREUS; TERPENES;

EID: 84899427900     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.537449     Document Type: Article

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