Administration dependent antioxidant effect of carica papaya seeds water extract

Evidence-based Complementary and Alternative Medicine

Volumn 2014, Issue , 2014, Pages

  Panzarini, Elisa ^a   Dwikat, Majdi ^a   Mariano, Stefania ^a   Vergallo, Cristian ^a   Dini, Luciana ^a  

^a UNIVERSITY OF SALENTO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CARICA PAPAYA EXTRACT; CATALASE; CYTOCHROME C; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; WATER;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PAPAYA; PLANT SEED; PROTEIN SECRETION; SKIN FIBROBLAST;

EID: 84899424854     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2014/281508     Document Type: Article

References (44)

1. Brieger K., Schiavone S., Miller F. J., Krause K. H., Reactive oxygen species: from health to disease. Swiss Medical Weekly 2012 142 1 14
2. Stanner S. A., Hughes J., Kelly C. N., Buttriss J., A review of the epidemiological evidence for the 'antioxidant hypothesis'. Public Health Nutrition 2004 7 3 407 422
3. Mursu J., Robien K., Harnack L. J., Park K., Jacobs D. R. Jr., Dietary supplements and mortality rate in older women: The Iowa Women's Health Study. Archives of Internal Medicine 2011 171 18 1625 1633 2-s2.0-80054732967 10.1001/archinternmed.2011.445
4. Ali A., Devarajan S., Waly M., Essa M. M., Rahman M. S., Essa M. M., Manickavasagan A., Sukumar E., Nutritional and medicinal value of papaya (Carica papaya L.). Natural Products and Bioactive Compounds in Disease Prevention 2011 New York, NY, USA Nova Science Publishers 34 42
5. Nakamura Y., Yoshimoto M., Murata Y., Shimoishi Y., Asai Y., Eun Y. P., Sato K., Nakamura Y., Papaya seed represents a rich source of biologically active isothiocyanate. Journal of Agricultural and Food Chemistry 2007 55 11 4407 4413 2-s2.0-34250636812 10.1021/jf070159w
6. Jaiswal P., Kumar P., Singh V. K., Singh D. K., Carica papaya Linn: a potential source for various health problems. Journal of Pharmacy Research 2010 3 5 998 1003
7. Krishna K. L., Paridhavi M., Patel J. A., Review on nutritional, medicinal and pharmacological properties of Papaya (Carica papaya Linn.). Natural Product Radiance 2008 7 4 364 373 2-s2.0-56249125958
8. Anuar N. S., Zahari S. S., Taib I. A., Rahman M. T., Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy. Food and Chemical Toxicology 2008 46 7 2384 2389 2-s2.0-44749089701 10.1016/j.fct.2008.03.025
9. Ajlia S. A. S. H., Majid F. A. A., Suvik A., Effendy M. A. W., Serati Nouri H., Efficacy of papain-based wound cleanser in promoting wound regeneration. Pakistan Journal of Biological Sciences 2010 13 12 596 603 2-s2.0-77954454398
10. Imaga N. A., Gbenle G. O., Okochi V. I., Adenekan S., Duro-Emmanuel T., Oyeniyi B., Dokai P. N., Oyenuga M., Otumara A., Ekeh F. C., Phytochemical and antioxidant nutrient constituents of Carica papaya and parquetina nigrescens extracts. Scientific Research and Essays 2010 5 16 2201 2205 2-s2.0-77958008028
11. Morimoto C., Dang N. H., Dang N., Cancer prevention and treating composition for preventing, ameliorating, or treating solid cancers, e.g. lung, or blood cancers, e.g. lymphoma, comprises components extracted from brewing papaya. Patent 2008 WO2006004226-A1, EP1778262-A1, JP2008505887-W, US2008069907-A1 YS Therapeutic Co Ltd (YSTH-Non-standard) Toudai Tlo Ltd (TODNon- standard) Morimoto C (MORI-Individual) Dang NH (DANG-Individual)
12. Otsuki N., Dang N. H., Kumagai E., Kondo A., Iwata S., Morimoto C., Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. Journal of Ethnopharmacology 2010 127 3 760 767 2-s2.0-76149088076 10.1016/j.jep.2009.11.024
13. Indran M., Mahmood A. A., Kuppusamy U. R., Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Medical Journal 2008 57 4 323 326 2-s2.0-58149084496
14. Kothari V., Seshadri S., Antioxidant activity of seed extracts of Annona squamosa and Carica papaya. Nutrition and Food Science 2010 40 4 403 408 2-s2.0-77955060532 10.1108/00346651011062050
15. Norshazila S., Zahir I. S., Suleiman K. M., Aisyah M. R., Rahim K. K., Antioxidant levels and activities of selected seeds of Malaysian tropical fruits. Malaysian Journal of Nutrition 2010 16 1 149 159 2-s2.0-77954299103
16. Contreras-Calderón J., Calderón-Jaimes L., Guerra-Hernández E., García-Villanova B., Antioxidant capacity, phenolic content and vitamin C in pulp, peel and seed from 24 exotic fruits from Colombia. Food Research International 2011 44 7 2047 2053 2-s2.0-79959936178 10.1016/j.foodres.2010.11.003
17. Zhou K., Wang H., Mei W., Li X., Luo Y., Dai H., Antioxidant activity of Papaya seed extracts. Molecules 2011 16 8 6179 6192
18. Sladowski D., Steer S. J., Clothier R. H., Balls M., An improved MTT assay. Journal of Immunological Methods 1993 157 203 207
19. 2+ indicators with greatly improved fluorescence properties. The Journal of Biological Chemistry 1985 260 6 3440 3450
20. Laemmli U. K., Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 1970 227 5259 680 685
21. Towbin H., Staehelin T., Gordon J., Electrophoretic transfer of proteins from polyacrilamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences of the United States of America 1979 76 9 4350 4354
22. Formichi P., Radi E., Battisti C., Human fibroblasts undergo oxidative stress-induced apoptosis without internucleosomal DNA fragmentation. Journal of Cellular Physiology 2006 208 2 289 297
23. Okonogi S., Duangrat C., Anuchpreeda S., Tachakittirungrod S., Chowwanapoonpohn S., Comparison of antioxidant capacities and cytotoxicities of certain fruit peel. Food Chemistry 2007 103 3 839 846
24. Peschel W., Sánchez-Rabaneda F., Diekmann W., An industrial approach in the search of natural antioxidants from vegetable and fruit wastes. Food Chemistry 2006 97 1 137 150
25. Okeniyi J. A. O., Ogunlesi T. A., Oyelami O. A., Adeyemi L. A., Effectiveness of dried Carica papaya seeds against human intestinal parasitosis: a pilot study. Journal of Medicinal Food 2007 10 1 194 196 2-s2.0-34248158866 10.1089/jmf.2005.065
26. Sapaat A., Satrija F., Mahsol H. H., Ahmad A. H., Anthelmintic activity of papaya seeds on Hymenolepis diminuta infections in rats. Tropical Biomedicine 2012 29 4 508 512
27. Oderinde O., Noronha C., Oremosu A., Kusemiju T., Okanlawon O. A., Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. The Nigerian Postgraduate Medical Journal 2002 9 2 95 98 2-s2.0-0036598725
28. Adebiyi A., Adaikan P. G., Prasad R. N. V., Tocolytic and toxic activity of papaya seed extract on isolated rat uterus. Life Sciences 2003 74 5 581 592 2-s2.0-0242408548 10.1016/j.lfs.2003.06.035
29. Chinoy N. J., D'Souza J. M., Padman P., Effects of crude aqueous extract of Carica papaya seeds in male albino mice. Reproductive Toxicology 1994 8 1 75 79 2-s2.0-0027963064
30. Lohiya N. K., Goyal R. B., Jayaprakash D., Ansari A. S., Sharma S., Antifertility effects of aqueous extract of Carica papaya seeds in male rats. Planta Medica 1994 60 5 400 404 2-s2.0-0028063797 10.1055/s-2006-959518
31. Udoh P., Essien I., Udoh F., Effects of Carica papaya (paw paw) seeds extract on the morphology of pituitary-gonadal axis of male Wistar rats. Phytotherapy Research 2005 19 12 1065 1068 2-s2.0-31144447608 10.1002/ptr.1388
32. Ortega-Pacheco A., Jimenez-Coello M., Acosta-Viana K. Y., Guzman-Marin E., Gutierrez-Blanco E., Luna-Flores W. S., Zavala-Sanchez M. A., Gonzalez-Robles A., Perez-Gutierrez M. S., Effects of papaya seeds extract on the sperm characteristics of dogs. Animal Reproduction Science 2011 129 1-2 82 88 2-s2.0-82955187811 10.1016/j.anireprosci.2011.10.002
33. Nayak B. S., Ramdeen R., Adogwa A., Ramsubhag A., Marshall J. R., Wound-healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds. International Wound Journal 2012 9 6 650 655 2-s2.0-84856436088 10.1111/j.1742-481X.2011.00933.x
34. Nguyen T. T., Shaw P. N., Parat M. O., Hewavitharana A. K., Anticancer activity of Carica papaya: a review. Molecular Nutrition & Food Research 2013 57 1 153 164
35. Dawkins G., Hewitt H. H., Wint Y., Obiefuna P. C. M., Wint B., Antibacterial effects of Carica papaya fruit on common wound organisms. West Indian Medical Journal 2003 52 4 290 292 2-s2.0-1542359999
36. Chávez-Quintal P., González-Flores T., Rodríguez- Buenfil I., Gallegos-Tintoré S., Antifungal activity in ethanolic extracts of Carica papaya L. cv. Maradol leaves and seeds. Indian Journal of Microbiology 2011 51 1 54 60 2-s2.0-79952814714 10.1007/s12088-011-0086-5
37. Ang Y. K., Sia W. C. M., Khoo H. E., Yim H. S., Antioxidant potential of Carica papaya peel and seed. Focusing on Modern Food Industry 2012 1 1 11 16
38. Vaya J., Aviram M M., Nutritional antioxidants: mechanisms of action, analyses of activities and medical application. Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 2001 1 1 99 117
39. Tasinato A., Boscoboinik D., Bartoli G.-M., Maroni P., Azzi A., d-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proceedings of the National Academy of Sciences of the United States of America 1995 92 26 12190 12194 2-s2.0-0029417282
40. Hensley K., Robinson K. A., Gabbita S. P., Salsman S., Floyd R. A., Reactive oxygen species, cell signaling, and cell injury. Free Radical Biology and Medicine 2000 28 10 1456 1462 2-s2.0-0034656849 10.1016/S0891-5849(00)00252- 5
41. Stewart-Lee A. L., Forster L. A., Nourooz-Zadeh J., Ferns G. A. A., Anggard E. E., Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits. Arteriosclerosis and Thrombosis 1994 14 3 494 499 2-s2.0-0028326665
42. Yakes F. M., Van Houten B., Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 1997 94 2 514 519 2-s2.0-0031032817 10.1073/pnas.94.2.514
43. Szeto H. H., Cell-permeable, mitochondrial-targeted, peptide antioxidants. The AAPS Journal 2006 8 2 E277 E283 2-s2.0-33646369165 10.1208/aapsj080232
44. Ermak G., Davies K. J. A., Calcium and oxidative stress: from cell signaling to cell death. Molecular Immunology 2002 38 10 713 721 2-s2.0-0036182380 10.1016/S0161-5890(01)00108-0