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Volumn 44, Issue 5, 2014, Pages 1727-1735

Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma

Author keywords

Bone morphogenetic protein 2; Expression; Methylation; Promoter; Rhabdomyosarcoma

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; BONE MORPHOGENETIC PROTEIN 2;

EID: 84899113456     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2312     Document Type: Article
Times cited : (9)

References (55)
  • 3
    • 1842791530 scopus 로고    scopus 로고
    • Soft tissue sarcomas of childhood
    • Meyer WH and Spunt SL: Soft tissue sarcomas of childhood. Cancer Treat Rev 30: 269-280, 2004.
    • (2004) Cancer Treat Rev , vol.30 , pp. 269-280
    • Meyer, W.H.1    Spunt, S.L.2
  • 7
    • 0035839886 scopus 로고    scopus 로고
    • Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
    • Barr FG: Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene 20: 5736-5746, 2001.
    • (2001) Oncogene , vol.20 , pp. 5736-5746
    • Barr, F.G.1
  • 8
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG and Rauscher FJ III: The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol 15: 1522-1535, 1995.
    • (1995) Mol Cell Biol , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3    Rovera, G.4    Bennicelli, J.5    Barr, F.G.6    Rauscher III, F.J.7
  • 9
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG and Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054, 2003.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 11
    • 1042301960 scopus 로고    scopus 로고
    • Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia
    • Wong IH, Chan J, Wong J and Tam PK: Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia. Clin Cancer Res 10: 994-1002, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 994-1002
    • Wong, I.H.1    Chan, J.2    Wong, J.3    Tam, P.K.4
  • 14
    • 0028960753 scopus 로고
    • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development
    • Lyons KM, Hogan BL and Robertson EJ: Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. Mech Dev 50: 71-83, 1995.
    • (1995) Mech Dev , vol.50 , pp. 71-83
    • Lyons, K.M.1    Hogan, B.L.2    Robertson, E.J.3
  • 15
    • 0029968609 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures
    • Duprez DM, Coltey M, Amthor H, Brickell PM and Tickle C: Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures. Dev Biol 174: 448-452, 1996.
    • (1996) Dev Biol , vol.174 , pp. 448-452
    • Duprez, D.M.1    Coltey, M.2    Amthor, H.3    Brickell, P.M.4    Tickle, C.5
  • 16
    • 0034064116 scopus 로고    scopus 로고
    • BMPs are necessary for stomach gland formation in the chicken embryo: A study using virally induced BMP-2 and Noggin expression
    • Narita T, Saitoh K, Kameda T, Kuroiwa A, Mizutani M, Koike C, Iba H and Yasugi S: BMPs are necessary for stomach gland formation in the chicken embryo: a study using virally induced BMP-2 and Noggin expression. Development 127: 981-988, 2000.
    • (2000) Development , vol.127 , pp. 981-988
    • Narita, T.1    Saitoh, K.2    Kameda, T.3    Kuroiwa, A.4    Mizutani, M.5    Koike, C.6    Iba, H.7    Yasugi, S.8
  • 17
  • 18
    • 0033538447 scopus 로고    scopus 로고
    • Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
    • Hollnagel A, Oehlmann V, Heymer J, Ruther U and Nordheim A: Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274: 19838-19845, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 19838-19845
    • Hollnagel, A.1    Oehlmann, V.2    Heymer, J.3    Ruther, U.4    Nordheim, A.5
  • 21
    • 0036121291 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells
    • Kawamura C, Kizaki M and Ikeda Y: Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Leuk Lymphoma 43: 635-639, 2002.
    • (2002) Leuk Lymphoma , vol.43 , pp. 635-639
    • Kawamura, C.1    Kizaki, M.2    Ikeda, Y.3
  • 22
    • 41149130332 scopus 로고    scopus 로고
    • Posttranscriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
    • Zhao H, Ayrault O, Zindy F, Kim JH and Roussel MF: Posttranscriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev 22: 722-727, 2008.
    • (2008) Genes Dev , vol.22 , pp. 722-727
    • Zhao, H.1    Ayrault, O.2    Zindy, F.3    Kim, J.H.4    Roussel, M.F.5
  • 23
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45, 2001.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 26
    • 34547792388 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer: The DNA hypermethylome
    • Esteller M: Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet 16 Spec No 1: R50-R59, 2007.
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC. NO 1
    • Esteller, M.1
  • 28
    • 0033918563 scopus 로고    scopus 로고
    • Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    • Dammann R, Li C, Yoon JH, Chin PL, Bates S and Pfeifer GP: Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 25: 315-319, 2000.
    • (2000) Nat Genet , vol.25 , pp. 315-319
    • Dammann, R.1    Li, C.2    Yoon, J.H.3    Chin, P.L.4    Bates, S.5    Pfeifer, G.P.6
  • 30
    • 0035888160 scopus 로고    scopus 로고
    • Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas
    • Yoon JH, Dammann R and Pfeifer GP: Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer 94: 212-217, 2001.
    • (2001) Int J Cancer , vol.94 , pp. 212-217
    • Yoon, J.H.1    Dammann, R.2    Pfeifer, G.P.3
  • 31
    • 0035300429 scopus 로고    scopus 로고
    • Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers
    • Dammann R, Yang G and Pfeifer GP: Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res 61: 3105-3109, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3105-3109
    • Dammann, R.1    Yang, G.2    Pfeifer, G.P.3
  • 33
    • 0035979253 scopus 로고    scopus 로고
    • Regulation of myostatin activity and muscle growth
    • Lee SJ and McPherron AC: Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci USA 98: 9306-9311, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9306-9311
    • Lee, S.J.1    McPherron, A.C.2
  • 34
    • 33646672441 scopus 로고    scopus 로고
    • Expression of the TGF-beta family of ligands is developmentally regulated in skeletal muscle of neonatal rats
    • Suryawan A, Frank JW, Nguyen HV and Davis TA: Expression of the TGF-beta family of ligands is developmentally regulated in skeletal muscle of neonatal rats. Pediatr Res 59: 175-179, 2006.
    • (2006) Pediatr Res , vol.59 , pp. 175-179
    • Suryawan, A.1    Frank, J.W.2    Nguyen, H.V.3    Davis, T.A.4
  • 37
    • 33646362788 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas
    • Wen XZ, Akiyama Y, Baylin SB and Yuasa Y: Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene 25: 2666-2673, 2006.
    • (2006) Oncogene , vol.25 , pp. 2666-2673
    • Wen, X.Z.1    Akiyama, Y.2    Baylin, S.B.3    Yuasa, Y.4
  • 38
    • 84860572092 scopus 로고    scopus 로고
    • Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas
    • Mahoney SE, Yao Z, Keyes CC, Tapscott SJ and Diede SJ: Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas. Epigenetics 7: 400-408, 2012.
    • (2012) Epigenetics , vol.7 , pp. 400-408
    • Mahoney, S.E.1    Yao, Z.2    Keyes, C.C.3    Tapscott, S.J.4    Diede, S.J.5
  • 39
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21, 2002.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 40
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M: Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8: 286-298, 2007.
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 41
    • 70649101154 scopus 로고    scopus 로고
    • Control of BMP gene expression by long-range regulatory elements
    • Pregizer S and Mortlock DP: Control of BMP gene expression by long-range regulatory elements. Cytokine Growth Factor Rev 20: 509-515, 2009.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 509-515
    • Pregizer, S.1    Mortlock, D.P.2
  • 42
    • 34147205885 scopus 로고    scopus 로고
    • Bmp2 transcription in osteoblast progenitors is regulated by a distant 3′ enhancer located 156.3 kilobases from the promoter
    • Chandler RL, Chandler KJ, McFarland KA and Mortlock DP: Bmp2 transcription in osteoblast progenitors is regulated by a distant 3′ enhancer located 156.3 kilobases from the promoter. Mol Cell Biol 27: 2934-2951, 2007.
    • (2007) Mol Cell Biol , vol.27 , pp. 2934-2951
    • Chandler, R.L.1    Chandler, K.J.2    McFarland, K.A.3    Mortlock, D.P.4
  • 43
    • 52049102456 scopus 로고    scopus 로고
    • Evolution of decitabine development: Accomplishments, ongoing investigations, and future strategies
    • Jabbour E, Issa JP, Garcia-Manero G and Kantarjian H: Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies. Cancer 112: 2341-2351, 2008.
    • (2008) Cancer , vol.112 , pp. 2341-2351
    • Jabbour, E.1    Issa, J.P.2    Garcia-Manero, G.3    Kantarjian, H.4
  • 44
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG and Baylin SB: Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21: 103-107, 1999.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 45
    • 77954393480 scopus 로고    scopus 로고
    • Demethylation by 5-aza-2′-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists
    • Mossman D, Kim KT and Scott RJ: Demethylation by 5-aza-2′- deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. BMC Cancer 10: 366, 2010.
    • (2010) BMC Cancer , vol.10 , pp. 366
    • Mossman, D.1    Kim, K.T.2    Scott, R.J.3
  • 46
    • 11844263357 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine reactivates the CDH1 gene without influencing the methylation of the entire CpG island or histone modification in a human cancer cell line
    • Tachibana K, Takeda K and Shiraishi M.: 5-Aza-2′-deoxycytidine reactivates the CDH1 gene without influencing the methylation of the entire CpG island or histone modification in a human cancer cell line. Proc Japan Acad 80: 342-348, 2004.
    • (2004) Proc Japan Acad , vol.80 , pp. 342-348
    • Tachibana, K.1    Takeda, K.2    Shiraishi, M.3
  • 47
    • 0034674353 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation
    • Ghosh-Choudhury N, Woodruff K, Qi W, Celeste A, Abboud SL and Ghosh Choudhury G: Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation. Biochem Biophys Res Commun 272: 705-711, 2000.
    • (2000) Biochem Biophys Res Commun , vol.272 , pp. 705-711
    • Ghosh-Choudhury, N.1    Woodruff, K.2    Qi, W.3    Celeste, A.4    Abboud, S.L.5    Ghosh Choudhury, G.6
  • 49
    • 1542375452 scopus 로고    scopus 로고
    • BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells
    • Wen XZ, Miyake S, Akiyama Y and Yuasa Y: BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem Biophys Res Commun 316: 100-106, 2004.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 100-106
    • Wen, X.Z.1    Miyake, S.2    Akiyama, Y.3    Yuasa, Y.4
  • 51
    • 77549084500 scopus 로고    scopus 로고
    • Effects of bone morphogenetic protein 2 on Id expression and neuroblastoma cell differentiation
    • Du Y and Yip H: Effects of bone morphogenetic protein 2 on Id expression and neuroblastoma cell differentiation. Differentiation 79: 84-92, 2010.
    • (2010) Differentiation , vol.79 , pp. 84-92
    • Du, Y.1    Yip, H.2
  • 52
    • 0027496995 scopus 로고
    • Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells
    • Ogata T, Wozney JM, Benezra R and Noda M: Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells. Proc Natl Acad Sci USA 90: 9219-9222, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9219-9222
    • Ogata, T.1    Wozney, J.M.2    Benezra, R.3    Noda, M.4
  • 54
    • 0033135325 scopus 로고    scopus 로고
    • Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line
    • Iantosca MR, McPherson CE, Ho SY and Maxwell GD: Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line. J Neurosci Res 56: 248-258, 1999.
    • (1999) J Neurosci Res , vol.56 , pp. 248-258
    • Iantosca, M.R.1    McPherson, C.E.2    Ho, S.Y.3    Maxwell, G.D.4
  • 55
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.