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Volumn 20, Issue 9, 2010, Pages 2903-2907

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists

Author keywords

ABCA1; Atherosclerosis; Cholesterol; Lipid; Liver X receptor; LXR; Quinoline; Sulfone

Indexed keywords

LIVER X RECEPTOR AGONIST; LOW DENSITY LIPOPROTEIN; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; QUINOLINE DERIVATIVE; SULFONE DERIVATIVE;

EID: 77950919411     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.031     Document Type: Article
Times cited : (12)

References (32)
  • 7
    • 77950920958 scopus 로고    scopus 로고
    • Nuclear Receptors Nomenclature Committee Cell
    • Nuclear Receptors Nomenclature Committee Cell 1999, 97, 161.
    • (1999) , vol.161 , Issue.97
  • 24
    • 77950919745 scopus 로고    scopus 로고
    • note
    • X-ray coordinates for the protein-ligand crystal structure were deposited in the RCSB Protein Data Bank, PDB deposition code 3KFC.
  • 27
    • 77950943049 scopus 로고    scopus 로고
    • note
    • 1H NMR, MS, and HRMS data. Compounds were generally >95% pure by HPLC analysis. Further experimental details are given in WO 2008049047.
  • 31
    • 77950926946 scopus 로고    scopus 로고
    • note
    • Compound 8a properties show a high cLog P, low TPSA 33 suggesting the possibility for CNS related side effects typical to those observed for compound 3. A blood brain penetration study was not conducted on this series of compounds.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.