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77950919745
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note
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X-ray coordinates for the protein-ligand crystal structure were deposited in the RCSB Protein Data Bank, PDB deposition code 3KFC.
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27
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77950943049
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note
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1H NMR, MS, and HRMS data. Compounds were generally >95% pure by HPLC analysis. Further experimental details are given in WO 2008049047.
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29
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31
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77950926946
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note
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Compound 8a properties show a high cLog P, low TPSA 33 suggesting the possibility for CNS related side effects typical to those observed for compound 3. A blood brain penetration study was not conducted on this series of compounds.
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32
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