Short communication: Is consumption of a cheese rich in angiotensin-converting enzyme-inhibiting peptides, such as the Norwegian cheese Gamalost, associated with reduced blood pressure?

Journal of Dairy Science

Volumn 97, Issue 5, 2014, Pages 2662-2668

  Nilsen, R ^a   Pripp, A H ^b   Hostmark A T ^c   Haug, A ^a   Skeie, S ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Angiotensin converting enzyme (ACE) inhibiting peptide; Blood pressure; Cheese; Dairy product

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PEPTIDE;

ANALYSIS; BLOOD PRESSURE; CHEESE; CROSS-SECTIONAL STUDY; DIET; DRUG EFFECTS; FEMALE; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; NORWAY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; BLOOD PRESSURE; CHEESE; CROSS-SECTIONAL STUDIES; DIET; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NORWAY; PEPTIDES;

EID: 84899102103     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2013-7479     Document Type: Article

References (29)

1. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., Jones D.W., Materson B.J., Oparil S., Wright J.T., Roccella E.J. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003, 42:1206-1252.
2. Engberink M.F., Schouten E.G., Kok F.J., van Mierlo L.A.J., Brouwer I.A., Geleijnse J.M. Lactotripeptides show no effect on human blood pressure: Results from a double-blind randomized controlled trial. Hypertension 2008, 51:399-405. http://dx.doi.org/10.1161/hypertensionaha.107.098988.
3. FitzGerald R.J., Murray B.A., Walsh D.J. Hypotensive peptides from milk proteins. J. Nutr. 2004, 134(Suppl. 4):980S-988S.
4. Folkehelseinstituttet. 2010. Folkehelserapport 2010 Helsetilstanden i Norge (Public Health Report 2010 Health in Norway). Folkehelseinstituttet (Norwegian Institute of Public Health), Oslo, Norway.
5. Griffith L.E., Guyatt G.H., Cook R.J., Bucher H.C., Cook D.J. The influence of dietary and nondietary calcium supplementation on blood pressure: An updated meta-analysis of randomized controlled trials. Am. J. Hypertens. 1999, 12:84-92.
6. Guinee T.P., Fox P.F. Salt in cheese: Physical, chemical and biological aspects. Cheese-Chemistry, Physics and Microbiology Volume 1: General Aspects 2004, 207-259. Elsevier Academic Press, London, UK. 3rd. T.P. Guinee, P.F. Fox, P.L.H. McSweeney, T.M. Cogan (Eds.).
7. Haque E., Chand R. Antihypertensive and antimicrobial bioactive peptides from milk proteins. Eur. Food Res. Technol. 2008, 227:7-15. http://dx.doi.org/10.1007/s00217-007-0689-6.
8. Hata Y., Yamamoto M., Ohni M., Nakajima K., Nakamura Y., Takano T. Placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am. J. Clin. Nutr. 1996, 64:767-771.
9. Høstmark A.T., Tomten S.E. The Oslo health study: Cheese intake was negatively associated with the metabolic syndrome. J. Am. Coll. Nutr. 2011, 30:182-190.
10. Houston M.C. The importance of potassium in managing hypertension. Curr. Hypertens. Rep. 2011, 13:309-317. http://dx.doi.org/10.1007/s11906-011-0197-8.
11. Korhonen H., Pihlanto A. Bioactive peptides: Production and functionality. Int. Dairy J. 2006, 16:945-960.
12. Krousel-Wood M.A., Muntner P., He J., Whelton P.K. Primary prevention of essential hypertension. Med. Clin. North Am. 2004, 88:223-238.
13. Lim S.S., Vos T., Flaxman A.D., Danaei G., Shibuya K., Adair-Rohani H., et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380:2224-2260. http://dx.doi.org/10.1016/S0140-6736(12)61766-8.
14. Mostøl, A. 2004. Dietary assessment-The weakest link? A dissertation exploring the limitations to questionnaire based methods of dietary assessment. PhD Thesis. University of Oslo, Oslo, Norway.
15. Pickering T.G., Hall J.E., Appel L.J., Falkner B.E., Graves J., Hill M.N., Jones D.W., Kurtz T., Sheps S.G., Roccella E.J. Recommendations for blood pressure measurement in humans and experimental animals. Hypertension 2005, 45:142-161. http://dx.doi.org/10.1161/01.HYP.0000150859.47929.8e.
16. Pripp A.H. Effect of peptides derived from food proteins on blood pressure: A meta-analysis of randomized controlled trials. Food Nutr. Res. 2008, 52. http://dx.doi.org/10.3402/fnr.v52i0.1641.
17. Pripp A.H., Sorensen R., Stepamak L., Sorhaug T. Relationship between proteolysis and angiotensin-I-converting enzyme inhibition in different cheeses. Lebenson. Wiss. Technol. 2006, 39:677-683. http://dx.doi.org/10.1016/j.lwt.2005.03.018.
18. Qureshi T.M., Vegarud G.E., Abrahamsen R.K., Skeie S. Characterization of the Norwegian autochthonous cheese Gamalost and its angiotensin I-converting enzyme (ACE) inhibitory activity during ripening. Dairy Sci. Technol. 2012, 92:613-625. http://dx.doi.org/10.1007/s13594-012-0078-1.
19. Qureshi T.M., Vegarud G.E., Abrahamsen R.K., Skeie S. Angiotensin 1-converting enzyme (ACE) inhibitory activity of the Norwegian autochthonous cheese Gamalost and Norvegia after in vitro human gastrointestinal digestion. J. Dairy Sci. 2013, 96:838-853. http://dx.doi.org/10.3168/jds.2012-5993.
20. Sacks F.M., Svetkey L.P., Vollmer W.M., Appel L.J., Bray G.A., Harsha D., Obarzanek E., Conlin P.R., Miller E.R., Simons-Morton D.G., Karanja N., Lin P.H. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N. Engl. J. Med. 2001, 344:3-10. for the DASH-Sodium Collaborative Research Group, http://dx.doi.org/10.1056/NEJM200101043440101.
21. Sieber R., Butikofer U., Egger C., Portman R., Walther B., Wechsler D. ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties. Dairy Sci. Technol. 2010, 90:47-73. http://dx.doi.org/10.1051/dst/2009049.
22. Silva S.V., Malcata F.X. Caseins as source of bioactive peptides. Int. Dairy J. 2005, 15:1-15. http://dx.doi.org/10.1016/j.idairyj.2004.04.009.
23. Soedamah-Muthu S.S., Verberne L.D.M., Ding E.L., Engberink M.F., Geleijnse J.M. Dairy consumption and incidence of hypertension: A dose-response meta-analysis of prospective cohort studies. Hypertension 2012, 60:1131-1137. http://dx.doi.org/10.1161/hypertensionaha.112.195206.
24. Sonestedt E., Wirfalt E., Wallstrom P., Gullberg B., Orho-Melander M., Hedblad B. Dairy products and its association with incidence of cardiovascular disease: The Malmo diet and cancer cohort. Eur. J. Epidemiol. 2011, 26:609-618. http://dx.doi.org/10.1007/s10654-011-9589-y.
25. Wang L., Manson J.E., Buring J.E., Lee I.M., Sesso H.D. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 2008, 51:1073-1079. http://dx.doi.org/10.1161/hypertensionaha.107.107821.
26. Whelton P., He J., Appel L. Primary prevention of hypertension: Clinical and public health advisory from the national high blood pressure education program. JAMA 2002, 288:1882-1888. http://dx.doi.org/10.1001/jama.288.15.1882.
27. Waist circumference and waist-hip ratio: Report of a WHO expert consultation 2011, WHO (World Health Organization), WHO, Geneva, Switzerland.
28. Wolf-Maier K., Cooper R.S., Banegas J.R., Giampaoli S., Hense H.W., Joffres M., Kastarinen M., Poulter N., Primatesta P., Rodríguez-Artalejo F., Stegmayr B., Thamm M., Tuomilehto J., Vanuzzo D., Vescio F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003, 289:2363-2369. http://dx.doi.org/10.1001/jama.289.18.2363.
29. Yoon S.S., Ostchega Y., Louis T. Recent trends in the prevalence of high blood pressure and its treatment and control, 1999-2008. NCHS Data Brief 2010, 48:1-8.