메뉴 건너뛰기




Volumn 3, Issue 2, 2014, Pages

Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy

Author keywords

4 1BB; Eomesodermin; Lag3; PD 1; T cells; Tumor immunotherapy

Indexed keywords

4 1 BB ANTIBODY; CD137 ANTIGEN; CELL ANTIBODY; EOMESODERMIN; LYMPHOCYTE ACTIVATION GENE 3; LYMPHOCYTE ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

EID: 84899101852     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.27680     Document Type: Article
Times cited : (18)

References (53)
  • 2
    • 84877059530 scopus 로고    scopus 로고
    • The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
    • PMID:23414607
    • Moran AE, Kovacsovics-Bankowski M, Weinberg AD. The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr Opin Immunol 2013; 25:230-7; PMID:23414607; http://dx.doi. org/10.1016/j.coi.2013.01.004.
    • (2013) Curr Opin Immunol , vol.25 , pp. 230-237
    • Moran, A.E.1    Kovacsovics-Bankowski, M.2    Weinberg, A.D.3
  • 3
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • PMID:22532596
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol Cancer Ther 2012; 11:1062-70; PMID:22532596; http://dx.doi.org/10.1158/1535-7163.MCT-11-0677.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 4
    • 66849135251 scopus 로고    scopus 로고
    • Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists
    • PMID:19659765
    • Peggs KS, Quezada SA, Allison JP. Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists. Clin Exp Immunol 2009; 157:9-19; PMID:19659765; http://dx.doi. org/10.1111/j.1365-2249.2009.03912.x.
    • (2009) Clin Exp Immunol , vol.157 , pp. 9-19
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 5
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • PMID:21074066
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010; 37:508-16; PMID:21074066; http://dx.doi.org/10.1053/j. seminoncol.2010.09.008.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 6
    • 77956214554 scopus 로고    scopus 로고
    • Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice
    • PMID:20543982
    • Lin GH, Liu Y, Ambagala T, Kwon BS, Ohashi PS, Watts TH. Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice. PLoS One 2010; 5:e11003; PMID:20543982; http://dx.doi. org/10.1371/journal.pone.0011003.
    • (2010) PLoS One , vol.5
    • Lin, G.H.1    Liu, Y.2    Ambagala, T.3    Kwon, B.S.4    Ohashi, P.S.5    Watts, T.H.6
  • 7
    • 0037096878 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells
    • PMID:12067989
    • May KF Jr., Chen L, Zheng P, Liu Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res 2002; 62:3459-65; PMID:12067989.
    • (2002) Cancer Res , vol.62 , pp. 3459-3465
    • May Jr., K.F.1    Chen, L.2    Zheng, P.3    Liu, Y.4
  • 8
    • 0037103147 scopus 로고    scopus 로고
    • 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner
    • PMID:12165501
    • Miller RE, Jones J, Le T, Whitmore J, Boiani N, Gliniak B, Lynch DH. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol 2002; 169:1792-800; PMID:12165501.
    • (2002) J Immunol , vol.169 , pp. 1792-1800
    • Miller, R.E.1    Jones, J.2    Le, T.3    Whitmore, J.4    Boiani, N.5    Gliniak, B.6    Lynch, D.H.7
  • 9
    • 65349153714 scopus 로고    scopus 로고
    • Immune regulation by 4-1BB and 4-1BBL: complexities and challenges
    • PMID:19426223
    • Wang C, Lin GH, McPherson AJ, Watts TH. Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev 2009; 229:192-215; PMID:19426223; http://dx.doi. org/10.1111/j.1600-065X.2009.00765.x.
    • (2009) Immunol Rev , vol.229 , pp. 192-215
    • Wang, C.1    Lin, G.H.2    McPherson, A.J.3    Watts, T.H.4
  • 10
    • 50949121437 scopus 로고    scopus 로고
    • ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo
    • PMID:18523273
    • Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH. ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo. J Immunol 2008; 180:8093-101; PMID:18523273.
    • (2008) J Immunol , vol.180 , pp. 8093-8101
    • Sabbagh, L.1    Pulle, G.2    Liu, Y.3    Tsitsikov, E.N.4    Watts, T.H.5
  • 11
    • 0036838689 scopus 로고    scopus 로고
    • 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1
    • PMID:12391199
    • Lee HW, Park SJ, Choi BK, Kim HH, Nam KO, Kwon BS. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J Immunol 2002; 169:4882-8; PMID:12391199.
    • (2002) J Immunol , vol.169 , pp. 4882-4888
    • Lee, H.W.1    Park, S.J.2    Choi, B.K.3    Kim, H.H.4    Nam, K.O.5    Kwon, B.S.6
  • 12
    • 84878648242 scopus 로고    scopus 로고
    • Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
    • PMID:23547098
    • Curran MA, Geiger TL, Montalvo W, Kim M, Reiner SL, Al-Shamkhani A, Sun JC, Allison JP. Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. J Exp Med 2013; 210:743-55; PMID:23547098; http://dx.doi.org/10.1084/jem.20121190.
    • (2013) J Exp Med , vol.210 , pp. 743-755
    • Curran, M.A.1    Geiger, T.L.2    Montalvo, W.3    Kim, M.4    Reiner, S.L.5    Al-Shamkhani, A.6    Sun, J.C.7    Allison, J.P.8
  • 13
    • 78149490392 scopus 로고    scopus 로고
    • Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche
    • PMID:20935204
    • Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol 2010; 185:4988-92; PMID:20935204; http://dx.doi.org/10.4049/jimmunol.1002042.
    • (2010) J Immunol , vol.185 , pp. 4988-4992
    • Banerjee, A.1    Gordon, S.M.2    Intlekofer, A.M.3    Paley, M.A.4    Mooney, E.C.5    Lindsten, T.6    Wherry, E.J.7    Reiner, S.L.8
  • 17
    • 0023821578 scopus 로고
    • Introduction of soluble protein into the class I pathway of antigen processing and presentation
    • PMID:3261634
    • Moore MW, Carbone FR, Bevan MJ. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 1988; 54:777-85; PMID:3261634; http://dx.doi.org/10.1016/S0092-8674(88)91043-4.
    • (1988) Cell , vol.54 , pp. 777-785
    • Moore, M.W.1    Carbone, F.R.2    Bevan, M.J.3
  • 18
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • PMID:11877473
    • Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 2002; 109:651-9; PMID:11877473; http://dx.doi. org/10.1172/JCI0214184.
    • (2002) J Clin Invest , vol.109 , pp. 651-659
    • Wilcox, R.A.1    Flies, D.B.2    Zhu, G.3    Johnson, A.J.4    Tamada, K.5    Chapoval, A.I.6    Strome, S.E.7    Pease, L.R.8    Chen, L.9
  • 19
    • 1842581762 scopus 로고    scopus 로고
    • Costimulation of CD8 T cell responses by OX40
    • PMID:15067059
    • Bansal-Pakala P, Halteman BS, Cheng MH, Croft M. Costimulation of CD8 T cell responses by OX40. J Immunol 2004; 172:4821-5; PMID:15067059.
    • (2004) J Immunol , vol.172 , pp. 4821-4825
    • Bansal-Pakala, P.1    Halteman, B.S.2    Cheng, M.H.3    Croft, M.4
  • 20
    • 0037087379 scopus 로고    scopus 로고
    • T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody
    • PMID:11884438
    • Tutt AL, O'Brien L, Hussain A, Crowther GR, French RR, Glennie MJ. T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody. J Immunol 2002; 168:2720-8; PMID:11884438.
    • (2002) J Immunol , vol.168 , pp. 2720-2728
    • Tutt, A.L.1    O'Brien, L.2    Hussain, A.3    Crowther, G.R.4    French, R.R.5    Glennie, M.J.6
  • 21
    • 0028178784 scopus 로고
    • T cell receptor antagonist peptides induce positive selection
    • PMID:8287475
    • Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 1994; 76:17-27; PMID:8287475; http://dx.doi. org/10.1016/0092-8674(94)90169-4.
    • (1994) Cell , vol.76 , pp. 17-27
    • Hogquist, K.A.1    Jameson, S.C.2    Heath, W.R.3    Howard, J.L.4    Bevan, M.J.5    Carbone, F.R.6
  • 22
    • 0035266427 scopus 로고    scopus 로고
    • Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation
    • PMID:11280763
    • Kim JA, Averbook BJ, Chambers K, Rothchild K, Kjaergaard J, Papay R, Shu S. Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation. Cancer Res 2001; 61:2031-7; PMID:11280763.
    • (2001) Cancer Res , vol.61 , pp. 2031-2037
    • Kim, J.A.1    Averbook, B.J.2    Chambers, K.3    Rothchild, K.4    Kjaergaard, J.5    Papay, R.6    Shu, S.7
  • 23
    • 79955785050 scopus 로고    scopus 로고
    • Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
    • PMID:21559358
    • Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 2011; 6:e19499; PMID:21559358; http://dx.doi.org/10.1371/journal. pone.0019499.
    • (2011) PLoS One , vol.6
    • Curran, M.A.1    Kim, M.2    Montalvo, W.3    Al-Shamkhani, A.4    Allison, J.P.5
  • 25
    • 75949118701 scopus 로고    scopus 로고
    • KLRG1-more than a marker for T cell senescence
    • PMID:19479342
    • Henson SM, Akbar AN. KLRG1-more than a marker for T cell senescence. Age (Dordr) 2009; 31:285-91; PMID:19479342; http://dx.doi.org/10.1007/s11357-009-9100-9.
    • (2009) Age (Dordr) , vol.31 , pp. 285-291
    • Henson, S.M.1    Akbar, A.N.2
  • 27
    • 77952275181 scopus 로고    scopus 로고
    • B16 as a mouse model for human melanoma
    • Chapter 20: Unit 20 1
    • Overwijk WW, Restifo NP. B16 as a mouse model for human melanoma. Curr Protoc Immunol 2001; Chapter 20:Unit 20 1.
    • (2001) Curr Protoc Immunol
    • Overwijk, W.W.1    Restifo, N.P.2
  • 28
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • PMID:9176498
    • Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, Mittler RS, Chen L. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997; 3:682-5; PMID:9176498; http://dx.doi. org/10.1038/nm0697-682.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3    Aruffo, A.4    Ledbetter, J.A.5    Hellström, K.E.6    Mittler, R.S.7    Chen, L.8
  • 29
    • 80054867338 scopus 로고    scopus 로고
    • T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy
    • PMID:22017440
    • Snell LM, Lin GH, McPherson AJ, Moraes TJ, Watts TH. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. Immunol Rev 2011; 244:197-217; PMID:22017440; http://dx.doi.org/10.1111/j.1600-065X.2011.01063.x.
    • (2011) Immunol Rev , vol.244 , pp. 197-217
    • Snell, L.M.1    Lin, G.H.2    McPherson, A.J.3    Moraes, T.J.4    Watts, T.H.5
  • 30
    • 41149173311 scopus 로고    scopus 로고
    • The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer
    • PMID:18364008
    • Lynch DH. The promise of 4-1BB (CD137)-mediated immunomodulation and the immunotherapy of cancer. Immunol Rev 2008;222:277-86; PMID:18364008; http://dx.doi. org/10.1111/j.1600-065X.2008.00621.x.
    • (2008) Immunol Rev , vol.222 , pp. 277-286
    • Lynch, D.H.1
  • 31
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • PMID:15548712
    • Ito F, Li Q, Shreiner AB, Okuyama R, Jure-Kunkel MN, Teitz-Tennenbaum S, Chang AE. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res 2004; 64:8411-9; PMID:15548712; http://dx.doi.org/10.1158/0008-5472.CAN-04-0590.
    • (2004) Cancer Res , vol.64 , pp. 8411-8419
    • Ito, F.1    Li, Q.2    Shreiner, A.B.3    Okuyama, R.4    Jure-Kunkel, M.N.5    Teitz-Tennenbaum, S.6    Chang, A.E.7
  • 32
    • 34548759728 scopus 로고    scopus 로고
    • Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy
    • PMID:17875731
    • Choi BK, Kim YH, Kang WJ, Lee SK, Kim KH, Shin SM, Yokoyama WM, Kim TY, Kwon BS. Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res 2007; 67:8891-9; PMID:17875731; http://dx.doi. org/10.1158/0008-5472.CAN-07-1056.
    • (2007) Cancer Res , vol.67 , pp. 8891-8899
    • Choi, B.K.1    Kim, Y.H.2    Kang, W.J.3    Lee, S.K.4    Kim, K.H.5    Shin, S.M.6    Yokoyama, W.M.7    Kim, T.Y.8    Kwon, B.S.9
  • 33
    • 34548017607 scopus 로고    scopus 로고
    • Mouse dendritic-endothelial cell hybrids and 4-1BB costimulation elicit antitumor effects mediated by broad antiangiogenic immunity
    • PMID:17699794
    • Ko E, Luo W, Peng L, Wang X, Ferrone S. Mouse dendritic-endothelial cell hybrids and 4-1BB costimulation elicit antitumor effects mediated by broad antiangiogenic immunity. Cancer Res 2007; 67:7875-84; PMID:17699794; http://dx.doi.org/10.1158/0008-5472.CAN-06-1744.
    • (2007) Cancer Res , vol.67 , pp. 7875-7884
    • Ko, E.1    Luo, W.2    Peng, L.3    Wang, X.4    Ferrone, S.5
  • 34
    • 60849125398 scopus 로고    scopus 로고
    • Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy
    • PMID:19190115
    • Kim YH, Choi BK, Oh HS, Kang WJ, Mittler RS, Kwon BS. Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy. Mol Cancer Ther 2009; 8:469-78; PMID:19190115; http://dx.doi.org/10.1158/1535-7163.MCT-08-0993.
    • (2009) Mol Cancer Ther , vol.8 , pp. 469-478
    • Kim, Y.H.1    Choi, B.K.2    Oh, H.S.3    Kang, W.J.4    Mittler, R.S.5    Kwon, B.S.6
  • 35
    • 0032535119 scopus 로고    scopus 로고
    • NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
    • PMID:9878117
    • Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 1998; 190:167-72; PMID:9878117; http://dx.doi.org/10.1006/cimm.1998.1396.
    • (1998) Cell Immunol , vol.190 , pp. 167-172
    • Melero, I.1    Johnston, J.V.2    Shufford, W.W.3    Mittler, R.S.4    Chen, L.5
  • 36
    • 0034616629 scopus 로고    scopus 로고
    • Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model
    • PMID:10841829
    • Martinet O, Ermekova V, Qiao JQ, Sauter B, Mandeli J, Chen L, Chen SH. Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model. J Natl Cancer Inst 2000; 92:931-6; PMID:10841829; http://dx.doi.org/10.1093/jnci/92.11.931.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 931-936
    • Martinet, O.1    Ermekova, V.2    Qiao, J.Q.3    Sauter, B.4    Mandeli, J.5    Chen, L.6    Chen, S.H.7
  • 39
    • 37249088549 scopus 로고    scopus 로고
    • Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer
    • PMID:18071585
    • Li Q, Iuchi T, Jure-Kunkel MN, Chang AE. Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer. Int J Biol Sci 2007; 3:455-62; PMID:18071585; http://dx.doi.org/10.7150/ijbs.3.455.
    • (2007) Int J Biol Sci , vol.3 , pp. 455-462
    • Li, Q.1    Iuchi, T.2    Jure-Kunkel, M.N.3    Chang, A.E.4
  • 40
    • 78649853665 scopus 로고    scopus 로고
    • T-bet and eomesodermin are required for T cell-mediated antitumor immune responses
    • PMID:20713880
    • Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol 2010; 185:3174-83; PMID:20713880; http://dx.doi.org/10.4049/jimmunol.1000749.
    • (2010) J Immunol , vol.185 , pp. 3174-3183
    • Zhu, Y.1    Ju, S.2    Chen, E.3    Dai, S.4    Li, C.5    Morel, P.6    Liu, L.7    Zhang, X.8    Lu, B.9
  • 41
    • 64049116467 scopus 로고    scopus 로고
    • CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin
    • PMID:19224637
    • Hegel JK, Knieke K, Kolar P, Reiner SL, Brunner-Weinzierl MC. CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. Eur J Immunol 2009; 39:883-93; PMID:19224637; http://dx.doi.org/10.1002/eji.200838770.
    • (2009) Eur J Immunol , vol.39 , pp. 883-893
    • Hegel, J.K.1    Knieke, K.2    Kolar, P.3    Reiner, S.L.4    Brunner-Weinzierl, M.C.5
  • 43
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: an overview of preclinical and translational research
    • PMID:23390376
    • Grosso JF, Jure-Kunkel MN. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 2013; 13:5; PMID:23390376.
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 44
    • 84874889330 scopus 로고    scopus 로고
    • Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
    • PMID:23460531
    • Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer Res 2013; 19:997-1008; PMID:23460531; http://dx.doi.org/10.1158/1078-0432.CCR-12-2214.
    • (2013) Clin Cancer Res , vol.19 , pp. 997-1008
    • Melero, I.1    Grimaldi, A.M.2    Perez-Gracia, J.L.3    Ascierto, P.A.4
  • 45
    • 80051925716 scopus 로고    scopus 로고
    • 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection
    • PMID:21742975
    • Vezys V, Penaloza-MacMaster P, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. J Immunol 2011; 187:1634-42; PMID:21742975; http://dx.doi. org/10.4049/jimmunol.1100077.
    • (2011) J Immunol , vol.187 , pp. 1634-1642
    • Vezys, V.1    Penaloza-MacMaster, P.2    Barber, D.L.3    Ha, S.J.4    Konieczny, B.5    Freeman, G.J.6    Mittler, R.S.7    Ahmed, R.8
  • 46
    • 34250156711 scopus 로고    scopus 로고
    • Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo
    • PMID:17325342
    • Xiao H, Huang B, Yuan Y, Li D, Han LF, Liu Y, Gong W, Wu FH, Zhang GM, Feng ZH. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res 2007; 13:1823-30; PMID:17325342; http://dx.doi.org/10.1158/1078-0432.CCR-06-2154.
    • (2007) Clin Cancer Res , vol.13 , pp. 1823-1830
    • Xiao, H.1    Huang, B.2    Yuan, Y.3    Li, D.4    Han, L.F.5    Liu, Y.6    Gong, W.7    Wu, F.H.8    Zhang, G.M.9    Feng, Z.H.10
  • 47
    • 79959375167 scopus 로고    scopus 로고
    • Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
    • PMID:21623380
    • Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol 2011; 12:663-71; PMID:21623380; http://dx.doi. org/10.1038/ni.2046.
    • (2011) Nat Immunol , vol.12 , pp. 663-671
    • Kao, C.1    Oestreich, K.J.2    Paley, M.A.3    Crawford, A.4    Angelosanto, J.M.5    Ali, M.A.6    Intlekofer, A.M.7    Boss, J.M.8    Reiner, S.L.9    Weinmann, A.S.10
  • 49
    • 84885716979 scopus 로고    scopus 로고
    • TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
    • PMID:23734331
    • Sakuishi K, Ngiow SF, Sullivan JM, Teng MW, Kuchroo VK, Smyth MJ, Anderson AC. TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer. Oncoimmunology 2013; 2:e23849; PMID:23734331; http://dx.doi.org/10.4161/onci.23849.
    • (2013) Oncoimmunology , vol.2
    • Sakuishi, K.1    Ngiow, S.F.2    Sullivan, J.M.3    Teng, M.W.4    Kuchroo, V.K.5    Smyth, M.J.6    Anderson, A.C.7
  • 50
    • 84862865552 scopus 로고    scopus 로고
    • LAG-3 in Cancer Immunotherapy
    • PMID:21086108
    • Goldberg MV, Drake CG. LAG-3 in Cancer Immunotherapy. Curr Top Microbiol Immunol 2011; 344:269-78; PMID:21086108; http://dx.doi. org/10.1007/82_2010_114.
    • (2011) Curr Top Microbiol Immunol , vol.344 , pp. 269-278
    • Goldberg, M.V.1    Drake, C.G.2
  • 51
    • 84886945237 scopus 로고    scopus 로고
    • A molecular profile of T-cell exhaustion in cancer
    • PMID:22737618
    • Speiser DE. A molecular profile of T-cell exhaustion in cancer. Oncoimmunology 2012; 1:369-71; PMID:22737618; http://dx.doi.org/10.4161/onci.18342.
    • (2012) Oncoimmunology , vol.1 , pp. 369-371
    • Speiser, D.E.1
  • 52
    • 79953041310 scopus 로고    scopus 로고
    • Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function
    • PMID:21389874
    • Hernandez-Chacon JA, Li Y, Wu RC, Bernatchez C, Wang Y, Weber JS, Hwu P, Radvanyi LG. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother 2011; 34:236-50; PMID:21389874; http://dx.doi. org/10.1097/CJI.0b013e318209e7ec.
    • (2011) J Immunother , vol.34 , pp. 236-250
    • Hernandez-Chacon, J.A.1    Li, Y.2    Wu, R.C.3    Bernatchez, C.4    Wang, Y.5    Weber, J.S.6    Hwu, P.7    Radvanyi, L.G.8
  • 53
    • 40049091217 scopus 로고    scopus 로고
    • 4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulationdependent rescue of functionally impaired HIVspecific CD8 T cells
    • PMID:18056369
    • Wang C, Wen T, Routy JP, Bernard NF, Sekaly RP, Watts TH. 4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulationdependent rescue of functionally impaired HIVspecific CD8 T cells. J Immunol 2007; 179:8252-63; PMID:18056369.
    • (2007) J Immunol , vol.179 , pp. 8252-8263
    • Wang, C.1    Wen, T.2    Routy, J.P.3    Bernard, N.F.4    Sekaly, R.P.5    Watts, T.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.