Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Chouchani, Edward T ^a,b   Methner, Carmen ^a   Buonincontri, Guido ^a   Hu, Chou Hui ^a   Logan, Angela ^b   Sawiak, Stephen J ^a   Murphy, Michael P ^b   Krieg, Thomas ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); NDUFS4 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOENERGY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; GENE; GENE DISRUPTION; GENE LOSS; HEART FUNCTION; HEART MUSCLE FIBROSIS; HYPERTROPHIC CARDIOMYOPATHY; IN VIVO STUDY; MOUSE; NDUFS4 GENE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION; PROTEIN ANALYSIS; PROTEIN CARBONYLATION; PROTEIN DEPLETION; PROTEIN FUNCTION; ANIMAL; CARDIOMYOPATHY, HYPERTROPHIC; DEFICIENCY; DISEASE MODEL; ENZYME ACTIVATION; FEMALE; GENETICS; HEART MITOCHONDRION; HEART VENTRICLE; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

ANIMALS; APOPTOSIS; CARDIOMYOPATHY, HYPERTROPHIC; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; ENZYME ACTIVATION; FEMALE; HEART VENTRICLES; HYDROGEN PEROXIDE; MAGNETIC RESONANCE IMAGING, CINE; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; REACTIVE OXYGEN SPECIES; SEVERITY OF ILLNESS INDEX;

EID: 84899100159     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094157     Document Type: Article

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