Dendritic peptide-based carriers for gene delivery

Current Drug Delivery

Volumn 6, Issue 4, 2009, Pages 338-342

  Coles, Daniel J ^a   Toth, Istvan ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cell penetrating peptides; Dendrimers; Gene delivery; Non viral carriers

Indexed keywords

CELL PENETRATING PEPTIDE; DENDRIMER; DRUG CARRIER; OLIGONUCLEOTIDE; POLYAMIDOAMINE; POLYETHYLENEIMINE; POLYLYSINE;

DRUG RESEARCH; DRUG STRUCTURE; GENE TARGETING; GENE THERAPY; PRIORITY JOURNAL; REVIEW;

DENDRIMERS; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; OLIGONUCLEOTIDES; PEPTIDES;

EID: 68949088286     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720109789000465     Document Type: Review

References (33)

1. Edelstein, M. L.; Abedi, M. R.; Wixon, J. Gene therapy clinical trials worldwide to 2007 - an update. J. Gene Med., 2007, 9, 833-842
2. Gene Therapy, U.S. DOE Human Genome Project, http://www.ornl.gov/sci/ techresources/Human-Genome/medicine/g enetherapy.shtml (accessed 05/05/09).
3. Toth, I.; Sakthivel, T.; Wilderspin, A. F.; Bayele, H.; O'Donnell, M.; Perry, D. J.; Pasi, K. J.; Lee, C. A.; Florence, A. T. Novel cationic lipidic peptide dendrimer vectors - In vitro gene delivery. Stp Pharma Sci., 1999, 9, 93-99
4. Lee, M.; Kim, S. W. Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm. Res., 2005, 22, 1-10. (Pubitemid 40558140)
5. Masotti, A.; Mossa, G.; Cametti, C.; Ortaggi, G.; Bianco, A.; Del Grosso, N.; Malizia, D.; Esposito, C. Comparison of different commercially available cationic liposome-DNA lipoplexes: Parameters influencing toxicity and transfection efficiency. Colloids Surf., B, 2009, 68, 136-144
6. Duncan, R.; Izzo, L., Dendrimer biocompatibility and toxicity. Adv. Drug Deliv. Rev. 2005, 57, 2215-2237
7. Gillies, E. R.; Frechet, J. M. J. Dendrimers and dendritic polymers in drug delivery. Drug Discov. Today, 2005, 10, 35-43.
8. Boas, U.; Heegaard, P. M. H. Dendrimers in drug research. Chem. Soc. Rev., 2004, 33, 43-63.
9. Eliyahu, H.; Barenholz, Y.; Domb, A. J. Polymers for DNA delivery. Molecules, 2005, 10, 34-64.
10. Lee, J. S.; Huh, J.; Ahn, C. H.; Lee, M.; Park, T. G. Synthesis of novel biodegradable cationic dendrimers. Macromol. Rapid Commun., 2006, 27, 1608-1614
11. Nam, H. Y.; Hahn, H. J.; Nam, K.; Choi, W. H.; Jeong, Y.; Kim, D. E.; Park, J. S. Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Int. J. Pharm., 2008, 363, 199-205.
12. Singh, P.; Gupta, U.; Asthana, A.; Jain, N. K. Folate and Folate- PEG-PAMAM Dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice. Bioconjug. Chem., 2008, 19, 2239-2252
13. Patil, M. L.; Zhang, M.; Betigeri, S.; Taratula, O.; He, H.; Minko, T. Surface-modified and internally cationic polyamidoamine dendrimers for efficient siRNA delivery. Bioconjug. Chem., 2008, 19, 1396-1403. (Pubitemid 352032339)
14. Kiselev, A. V.; Il'ina, P. L.; Egorova, A. A.; Baranov, A. N.; Guryanov, I. A.; Bayanova, N. V.; Tarasenko, II; Lesina, E. A.; Vlasov, G. P.; Baranov, V. S. Lysine dendrimers as vectors for delivery of genetic constructs to eukaryotic cells. Russ. J. Genet., 2007, 43, 593-600.
15. Boyd, B. J.; Kaminskas, L. M.; Karellas, P.; Krippner, G.; Lessene, R.; Porter, C. J. H. Cationic poly-L-lysine dendrimers: Pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats. Mol. Pharm., 2006, 3, 614-627
16. Bikram, M.; Ahn, C. H.; Chae, S. Y.; Lee, M. Y.; Yockman, J. W.; Kim, S. W. Biodegradable poly(ethylene glycol)-co-poly(L-lysine)- g-histidine multiblock copolymers for nonviral gene delivery. Macromolecules, 2004, 37, 1903-1916
17. Hartmann, L.; Haefele, S.; Peschka-Suess, R.; Antonietti, M.; Borner, H. G., Tailor-made poly(amidoamine)s for controlled complexation and condensation of DNA. Chem. Eur. J., 2008, 14, 2025-2033
18. Wen, Y. T.; Pan, S. R.; Luo, X.; Zhang, X.; Zhang, W.; Feng, M. A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector. Bioconjug. Chem., 2009, 20, 322-332
19. Intra, J.; Salem, A. K. Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. J. Control. Release, 2008, 130, 129-138
20. Ko, Y. T.; Kale, A.; Hartner, W. C. Papahadjopoulos-Sternberg, B.; Torchilin, V. P. Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery. J. Control. Release, 2009, 133, 132-138
21. Choi, S.; Lee, K. D. Enhanced gene delivery using disulfide-crosslinked low molecular weight polyethylenimine with listeriolysin o-polyethylenimine disulfide conjugate. J. Control. Release, 2008, 131, 70-76.
22. Wimmer, N.; Marano, R. J.; Kearns, P. S.; Rakoczy, E. P.; Toth, I. Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. Bioorg. Med. Chem. Lett., 2002, 12, 2635-2637 (Pubitemid 35245297)
23. Marano, R. J.; Wimmer, N.; Kearns, P. S.; Thomas, B. G.; Toth, I.; Brankov, M.; Rakoczy, P. E. Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp. Eye Res., 2004, 79, 525-535
24. Marano, R. J.; Toth, I.; Wimmer, N.; Brankov, M.; Rakoczy, P. E. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther., 2005, 12, 1544-1550
25. Blanchfield, J.; Toth, I. Lipid, sugar and liposaccharide based delivery systems 2. Curr. Med. Chem., 2004, 11, 2375-2382
26. Parekh, H. S.; Marano, R. J.; Rakoczy, E. P.; Blanchfield, J.; Toth, I. Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorg. Med. Chem., 2006, 14, 4775-4780 (Pubitemid 43767118)
27. Coles, D. J.; Yang, S.; Esposito, A.; Mitchell, D.; Minchin, R. F.; Toth, I. The synthesis and characterisation of a novel dendritic system for gene delivery. Tetrahedron, 2007, 63, 12207-12214 (Pubitemid 47600285)
28. Deshayes, S.; Morris, M. C.; Divita, G.; Heitz, F. Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cell. Mol. Life Sci., 2005, 62, 1839-1849 (Pubitemid 41188523)
29. Kerkis, A.; Hayashi, M. A. F.; Yamane, T.; Kerkis, I. Properties of cell penetrating peptides (CPPs). IUBMB Life, 2006, 58, 7-13.
30. Vaysse, L.; Gregory, L. G.; Harbottle, R. P.; Perouzel, E.; Tolmachov, O.; Coutelle, C. Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo. J. Gene Med., 2006, 8, 754-763 (Pubitemid 43919282)
31. Coles, D. J.; Yang, S.; Minchin, R. F.; Toth, I. The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry. Biopolymers, 2008, 90, 651-654
32. Yang, S.; Coles, D. J.; Esposito, A.; Mitchell, D. J.; Toth, I.; Minchin, R. F. Cellular uptake of self-assembled cationic peptide- DNA complexes: Multifunctional role of the enhancer chloroquine. J. Control. Release, 2009, 135, 159-165
33. Cho, Y. W.; Kim, J. D.; Park, K. Polycation gene delivery systems: escape from endosomes to cytosol. J. Pharm. Pharmacol., 2003, 55, 721-734 (Pubitemid 36752715)