메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages 205-212

Metreleptin for metabolic disorders associated with generalized or partial lipodystrophy

Author keywords

Diabetes mellitus; Hypertriglyceridemia; Insulin resistance; Leptin therapy; Lipodystrophy; Metreleptin; Steatohepatitis

Indexed keywords

GLUCOSE; METRELEPTIN;

EID: 84899067628     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/17446651.2014.894877     Document Type: Article
Times cited : (11)

References (47)
  • 1
    • 80655145234 scopus 로고    scopus 로고
    • Clinical review: Lipodystrophies: Genetic and acquired body fat disorders
    • Garg A. Clinical review: lipodystrophies: genetic and acquired body fat disorders. J Clin Endocrinol Metab 2011;96(11): 3313-25
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.11 , pp. 3313-3325
    • Garg, A.1
  • 2
    • 77953939677 scopus 로고    scopus 로고
    • Clinical classification and treatment of congenital and acquired lipodystrophy
    • Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract 2010;16(2): 310-23
    • (2010) Endocr Pract , vol.16 , Issue.2 , pp. 310-323
    • Chan, J.L.1    Oral, E.A.2
  • 4
    • 84878656502 scopus 로고    scopus 로고
    • Leptin?s role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals
    • Moon HS, Dalamaga M, Kim SY, et al. Leptin?s role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocr Rev 2013; 34(3):377-412
    • (2013) Endocr Rev , vol.34 , Issue.3 , pp. 377-412
    • Moon, H.S.1    Dalamaga, M.2    Kim, S.Y.3
  • 6
    • 84880036446 scopus 로고    scopus 로고
    • Balancing the fat: Lipid droplets and human disease
    • Krahmer N, Farese RV Jr, Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med 2013;5(7):905-15
    • (2013) EMBO Mol Med , vol.5 , Issue.7 , pp. 905-915
    • Krahmer, N.1    Farese Jr., R.V.2    Walther, T.C.3
  • 7
    • 0344442411 scopus 로고    scopus 로고
    • Phenotypic Heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes
    • DOI 10.1210/jc.2003-030835
    • Simha V, Garg A. Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. J Clin Endocrinol Metab 2003; 88(11):5433-7 (Pubitemid 37452750)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.11 , pp. 5433-5437
    • Simha, V.1    Garg, A.2
  • 9
    • 0036093225 scopus 로고    scopus 로고
    • Serum adiponectin and leptin levels in patients with lipodystrophies
    • Haque WA, Shimomura I, Matsuzawa Y, Garg A. Serum adiponectin and leptin levels in patients with lipodystrophies. J Clin Endocrinol Metab 2002;87(5):2395
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.5 , pp. 2395
    • Haque, W.A.1    Shimomura, I.2    Matsuzawa, Y.3    Garg, A.4
  • 10
    • 0037339129 scopus 로고    scopus 로고
    • Clinical features and metabolic derangements in acquired generalized lipodystrophy case reports and review of the literature
    • DOI 10.1097/00005792-200303000-00007
    • Misra A, Garg A. Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore) 2003;82(2):129-46 (Pubitemid 36331644)
    • (2003) Medicine , vol.82 , Issue.2 , pp. 129-146
    • Misra, A.1    Garg, A.2
  • 11
    • 1542642958 scopus 로고    scopus 로고
    • Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: Report of 35 cases and review of the literature
    • DOI 10.1097/01.md.0000111061.69212.59
    • Misra A, Peethambaram A, Garg A. Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature. Medicine (Baltimore) 2004;83(1):18-34 (Pubitemid 38124853)
    • (2004) Medicine , vol.83 , Issue.1 , pp. 18-34
    • Misra, A.1    Peethambaram, A.2    Garg, A.3
  • 12
    • 84881513620 scopus 로고    scopus 로고
    • The clinical approach to the detection of lipodystrophy - An AACE consensus statement
    • Handelsman Y, Oral EA, Bloomgarden ZT, et al. The clinical approach to the detection of lipodystrophy - an AACE consensus statement. Endocr Pract 2013;19(1):107-16
    • (2013) Endocr Pract , vol.19 , Issue.1 , pp. 107-116
    • Handelsman, Y.1    Oral, E.A.2    Bloomgarden, Z.T.3
  • 13
    • 84885977479 scopus 로고    scopus 로고
    • Novel forms of lipodystrophy: Why should we care?
    • Rother KI, Brown RJ. Novel forms of lipodystrophy: why should we care? Diabetes Care 2013;36(8):2142-5
    • (2013) Diabetes Care , vol.36 , Issue.8 , pp. 2142-2145
    • Rother, K.I.1    Brown, R.J.2
  • 15
    • 11344293751 scopus 로고    scopus 로고
    • Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    • DOI 10.1056/NEJMra041811
    • Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005;352(1):48-62 (Pubitemid 40075680)
    • (2005) New England Journal of Medicine , vol.352 , Issue.1 , pp. 48-62
    • Grinspoon, S.1    Carr, A.2
  • 17
    • 0036724616 scopus 로고    scopus 로고
    • Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy
    • Colombo C, Cutson JJ, Yamauchi T, et al. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes 2002;51(9):2727-33 (Pubitemid 34970925)
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2727-2733
    • Colombo, C.1    Cutson, J.J.2    Yamauchi, T.3    Vinson, C.4    Kadowaki, T.5    Gavrilova, O.6    Reitman, M.L.7
  • 18
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401(6748):73-6
    • (1999) Nature , vol.401 , Issue.6748 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3
  • 20
    • 34347253938 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: Variation of concentration-dependent parameters according to assay
    • DOI 10.1210/jc.2006-2864
    • Chan JL, Wong SL, Orlova C, et al. Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentrationdependent parameters according to assay. J Clin Endocrinol Metab 2007;92(6): 2307-11 (Pubitemid 46997138)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.6 , pp. 2307-2311
    • Chan, J.L.1    Wong, S.L.2    Orlova, C.3    Raciti, P.4    Mantzoros, C.S.5
  • 21
    • 84879467338 scopus 로고    scopus 로고
    • Metreleptin: First global approval
    • Chou K, Perry CM. Metreleptin: first global approval. Drugs 2013;73(9):989-97
    • (2013) Drugs , vol.73 , Issue.9 , pp. 989-997
    • Chou, K.1    Perry, C.M.2
  • 22
    • 84899058207 scopus 로고    scopus 로고
    • Bristol Myers Squibb Press release, [Last accessed 11 December 2013]
    • Bristol Myers Squibb Press release. FDA Advisory Committee Votes on Investigational Medicine Metreleptin. Available from: http://news.bms.com/ pressrelease/ rd-news/fda-advisory-committeevotes- investigational-medicine- metreleptin [Last accessed 11 December 2013]
    • FDA Advisory Committee Votes on Investigational Medicine Metreleptin
  • 23
    • 21344447493 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with generalized lipodystrophy
    • DOI 10.2337/diabetes.54.7.1994
    • Javor ED, Cochran EK, Musso C, et al. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 2005;54(7):1994-2002 (Pubitemid 40911261)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1994-2002
    • Javor, E.D.1    Cochran, E.K.2    Musso, C.3    Young, J.R.4    DePaoli, A.M.5    Gorden, P.6
  • 24
    • 84862951024 scopus 로고    scopus 로고
    • Clinical effects of long-term metreleptin treatment in patients with lipodystrophy
    • Chan JL, Lutz K, Cochran E, et al. Clinical effects of long-term metreleptin treatment in patients with lipodystrophy. Endocr Pract 2011;17(6):922-32
    • (2011) Endocr Pract , vol.17 , Issue.6 , pp. 922-932
    • Chan, J.L.1    Lutz, K.2    Cochran, E.3
  • 25
    • 33846950833 scopus 로고    scopus 로고
    • Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy
    • Ebihara K, Kusakabe T, Hirata M, et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J Clin Endocrinol Metab 2007;92(2):532-41
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.2 , pp. 532-541
    • Ebihara, K.1    Kusakabe, T.2    Hirata, M.3
  • 28
    • 84928214445 scopus 로고    scopus 로고
    • Consequences of stopping and restarting leptin in an adolescent with lipodystrophy
    • Kamran F, Rother KI, Cochran E, et al. Consequences of stopping and restarting leptin in an adolescent with lipodystrophy. Horm Res Paediatr 2012;78(5-6):320-5
    • (2012) Horm Res Paediatr , vol.78 , Issue.5-6 , pp. 320-325
    • Kamran, F.1    Rother, K.I.2    Cochran, E.3
  • 29
    • 0043172530 scopus 로고    scopus 로고
    • Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy
    • DOI 10.2337/diacare.26.1.30
    • Simha V, Szczepaniak LS, Wagner AJ, et al. Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care 2003;26(1):30-5 (Pubitemid 36928991)
    • (2003) Diabetes Care , vol.26 , Issue.1 , pp. 30-35
    • Simha, V.1    Szczepaniak, L.S.2    Wagner, A.J.3    Depaoli, A.M.4    Garg, A.5
  • 32
    • 84879130540 scopus 로고    scopus 로고
    • The liver diseases of lipodystrophy: The long-term effect of leptin treatment
    • Safar Zadeh E, Lungu AO, Cochran EK, et al. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol 2013;59(1):131-7
    • (2013) J Hepatol , vol.59 , Issue.1 , pp. 131-137
    • Safar Zadeh, E.1    Lungu, A.O.2    Cochran, E.K.3
  • 33
    • 84886801675 scopus 로고    scopus 로고
    • Post-liver transplant leptin results in resolution of severe recurrence of lipodystrophy-associated nonalcoholic steatohepatitis
    • Casey SP, Lokan J, Testro A, et al. Post-liver transplant leptin results in resolution of severe recurrence of lipodystrophy-associated nonalcoholic steatohepatitis. Am J Transplant 2013; 13(11):3031-4
    • (2013) Am J Transplant , vol.13 , Issue.11 , pp. 3031-3034
    • Casey, S.P.1    Lokan, J.2    Testro, A.3
  • 34
    • 84858027751 scopus 로고    scopus 로고
    • Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety
    • Simha V, Subramanyam L, Szczepaniak L, et al. Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety. J Clin Endocrinol Metab 2012;97(3):785-92
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.3 , pp. 785-792
    • Simha, V.1    Subramanyam, L.2    Szczepaniak, L.3
  • 35
    • 33947283865 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy
    • DOI 10.1016/j.metabol.2006.11.010, PII S0026049506004355
    • Park JY, Javor ED, Cochran EK, et al. Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy. Metabolism 2007;56(4): 508-16 (Pubitemid 46427848)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 508-516
    • Park, J.Y.1    Javor, E.D.2    Cochran, E.K.3    DePaoli, A.M.4    Gorden, P.5
  • 36
    • 33745781499 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy
    • DOI 10.1210/jc.2005-1545
    • Lee JH, Chan JL, Sourlas E, et al. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab 2006;91(7):2605-11 (Pubitemid 44024625)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.7 , pp. 2605-2611
    • Lee, J.H.1    Chan, J.L.2    Sourlas, E.3    Raptopoulos, V.4    Mantzoros, C.S.5
  • 37
    • 65249130126 scopus 로고    scopus 로고
    • The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia
    • Mulligan K, Khatami H, Schwarz JM, et al. The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. J Clin Endocrinol Metab 2009;94(4):1137-44
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.4 , pp. 1137-1144
    • Mulligan, K.1    Khatami, H.2    Schwarz, J.M.3
  • 38
    • 79959364721 scopus 로고    scopus 로고
    • Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: A pilot study
    • Magkos F, Brennan A, Sweeney L, et al. Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study. Metabolism 2011;60(7): 1045-9
    • (2011) Metabolism , vol.60 , Issue.7 , pp. 1045-1049
    • Magkos, F.1    Brennan, A.2    Sweeney, L.3
  • 39
    • 84866734963 scopus 로고    scopus 로고
    • Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome
    • Sekhar RV, Jahoor F, Iyer D, et al. Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome. Metabolism 2012;61(10): 1395-403
    • (2012) Metabolism , vol.61 , Issue.10 , pp. 1395-1403
    • Sekhar, R.V.1    Jahoor, F.2    Iyer, D.3
  • 41
    • 84867256114 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy
    • Aotani D, Ebihara K, Sawamoto N, et al. Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy. J Clin Endocrinol Metab 2012;97(10):3663-71
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.10 , pp. 3663-3671
    • Aotani, D.1    Ebihara, K.2    Sawamoto, N.3
  • 42
    • 77953356804 scopus 로고    scopus 로고
    • Gluttony sloth and the metabolic syndrome: A roadmap to lipotoxicity
    • Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 2010;21(6):345-52
    • (2010) Trends Endocrinol Metab , vol.21 , Issue.6 , pp. 345-352
    • Unger, R.H.1    Scherer, P.E.2
  • 43
    • 84870022667 scopus 로고    scopus 로고
    • Leptin activates hepatic 5?-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: A potential mechanism for improvement of fatty liver in lipodystrophy by leptin
    • Miyamoto L, Ebihara K, Kusakabe T, et al. Leptin activates hepatic 5?-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin. J Biol Chem 2012;287(48):40441-7
    • (2012) J Biol Chem , vol.287 , Issue.48 , pp. 40441-40447
    • Miyamoto, L.1    Ebihara, K.2    Kusakabe, T.3
  • 47
    • 77952692495 scopus 로고    scopus 로고
    • Resistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: An immunological origin
    • Beltrand J, Lahlou N, Le Charpentier T, et al. Resistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: an immunological origin. Eur J Endocrinol 2010;162(6):1083-91
    • (2010) Eur J Endocrinol , vol.162 , Issue.6 , pp. 1083-1091
    • Beltrand, J.1    Lahlou, N.2    Le Charpentier, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.