Leptin activates hepatic 5′-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: A potential mechanism for improvement of fatty liver in lipodystrophy by leptin

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40441-40447

  Miyamoto, Licht ^a,d   Ebihara, Ken ^a,b   Kusakabe, Toru ^a   Aotani, Daisuke ^a   Yamamoto Kataoka, Sachiko ^a   Sakai, Takeru ^a   Aizawa Abe, Megumi ^a,b   Yamamoto, Yuji ^a   Fujikura, Junji ^a   Hayashi, Tatsuya ^c   Hosoda, Kiminori ^a,b   Nakao, Kazuwa ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASE; AMPK ACTIVITY; BLOOD GLUCOSE LEVEL; CENTRAL NERVOUS SYSTEMS; DOWN-REGULATION; ENERGY HOMEOSTASIS; FAT ACCUMULATION; FATTY LIVER; LIPODYSTROPHY; METABOLIC DISORDERS; PATHOPHYSIOLOGICAL; POTENTIAL MECHANISM; SKELETAL MUSCLE; SYMPATHETIC NERVES; SYMPATHETIC NERVOUS SYSTEMS; THERAPEUTIC EFFECTS;

GLUCOSE; MAMMALS; METABOLISM; MUSCLE;

HORMONES;

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ALPHA 1 ADRENERGIC RECEPTOR; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; PLACEBO; PRAZOSIN; PROPRANOLOL; TRIACYLGLYCEROL;

ADRENERGIC ACTIVITY; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; INFUSION PUMP; LIPODYSTROPHY; LIPOLYSIS; LIVER; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SKELETAL MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; FATTY LIVER; FEMALE; HEPATOCYTES; HUMANS; LEPTIN; LIPODYSTROPHY; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; SYMPATHETIC NERVOUS SYSTEM;

MUS;

EID: 84870022667     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.384545     Document Type: Article

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