HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Huang, Liangqian ^a   Yu, Zhenhai ^b   Zhang, Teng ^a   Zhao, Xiaoping ^a   Huang, Gang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 40; OXYGEN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TUMOR CELL;

CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; GLUCOSE; GLYCOLYSIS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; PYRUVATE KINASE;

EID: 84899058278     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092949     Document Type: Article

References (37)

1. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
2. Warburg O (1956) On the origin of cancer cells. Science 123: 309-314.
3. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
4. Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, et al. (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7: 77-85. (Pubitemid 40126384)
5. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metabolism 7: 11-20.
6. Dombrauckas JD, Santarsiero BD, Mesecar AD (2005) Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 44: 9417-9429. (Pubitemid 40962040)
7. Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (2005) Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15: 300-308. (Pubitemid 41058775)
8. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, et al. (2012) EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis. Molecular Cell 48: 771-784.
9. Yang W, Xia Y, Hawke D, Li X, Liang J, et al. (2012) PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150: 685-696.
10. Yang W, Xia Y, Ji H, Zheng Y, Liang J, et al. (2011) Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature 480: 118-122.
11. Sterrenberg JN, Blatch GL, Edkins AL (2011) Human DNAJ in cancer and stem cells. Cancer Letters 312: 129-142.
12. Qiu XB, Shao YM, Miao S, Wang L (2006) The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cellular and Molecular Life Sciences 63: 2560-2570. (Pubitemid 44800711)
13. Jaattela M (1999) Heat shock proteins as cellular lifeguards. Annals of Medicine 31: 261-271.
14. Mitra A, Shevde LA, Samant RS (2009) Multi-faceted role of HSP40 in cancer. Clin Exp Metastasis 26: 559-567.
15. Yu L (2012) DNAJC25 is downregulated in hepatocellular carcinoma and is a novel tumor suppressor gene. Oncology Letters.
16. Wang CC (2006) HDJ-2 as a Target for Radiosensitization of Glioblastoma Multiforme Cells by the Farnesyltransferase Inhibitor R115777 and the Role of the p53/p21 Pathway. Cancer Research 66: 6756-6762.
17. Mitra A, Fillmore RA, Metge BJ, Rajesh M, Xi Y, et al. (2008) Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer. Breast Cancer Research 10.
18. Soo ETL, Yip GWC, Lwin ZM, Kumar SD, Bay BH (2008) Heat shock proteins as novel therapeutic targets in cancer. In Vivo 22: 311-315.
19. Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress & Chaperones 10: 86-103. (Pubitemid 40942470)
20. Jo S, Kallo I, Bardoczi Z, Arrojo e Drigo R, Zeold A, et al. (2012) Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism. Journal of Neuroscience 32: 8491-8500.
21. Qi M, Zhang J, Zeng W, Chen X (2013) DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner. Biochim Biophys Acta 1839: 62-69.
22. Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, et al. (2012) Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest 122: 2417-2427.
23. Pike LS, Smift AL, Croteau NJ, Ferrick DA, Wu M (2011) Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochimica Et Biophysica Acta-Bioenergetics 1807: 726-734.
24. Anastasiou D, Yu YM, Israelsen WJ, Jiang JK, Boxer MB, et al. (2012) Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (vol 8, pg 839, 2012). Nature Chemical Biology 8: 1008-1008.
25. Yu Z, Huang L, Zhang T, Yang F, Xie L, et al. (2013) PIM2 phosphorylates PKM2 and promotes Glycolysis in Cancer Cells. J Biol Chem.
26. Wu SF, Le HY (2013) Dual roles of PKM2 in cancer metabolism. Acta Biochimica Et Biophysica Sinica 45: 27-35.
27. Lv L, Li D, Zhao D, Lin R, Chu Y, et al. (2011) Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell 42: 719-730.
28. Minami Y, Hohfeld J, Ohtsuka K, Hartl FU (1996) Regulation of the heat-shock protein 70 reaction cycle by the mammalian DnaJ homolog, Hsp40. THE JOURNAL OF BIOLOGICAL CHEMISTRY 271: 19617-19624. (Pubitemid 26271642)
29. Newington JT, Rappon T, Albers S, Wong DY, Rylett RJ, et al. (2012) Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and reactive oxygen species production. J Biol Chem 287: 37245-37258.
30. Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337.
31. Chaneton B, Gottlieb E (2012) Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci 37: 309-316.
32. Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, et al. (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491: 458-+.
33. Keller KE, Tan IS, Lee YS (2012) SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions. Science 338: 1069-1072.
34. Guo CX, Linton A, Jalaie M, Kephart S, Ornelas M, et al. (2013) Discovery of 2-((1H-benzo[d]imidazol-1-yl) methyl)-4H-pyrido [1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorganic & Medicinal Chemistry Letters 23: 3358-3363.
35. Gao XL, Wang HZ, Yang JJ, Chen J, Jie J, et al. (2013) Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals. Journal of Biological Chemistry 288: 15971-15979.
36. Chen J, Jiang Z, Wang B, Wang Y, Hu X (2012) Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2. Cancer Lett 316: 204-210.
37. Ohtsuka K, Hata M (2000) Molecular chaperone function of mammalian Hsp70 and Hsp40 - a review. Int J Hyperthermia 16: 231-245. (Pubitemid 30391859)