Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer

Journal of Urology

Volumn 191, Issue 5, 2014, Pages 1429-1438

  Hsu, Jui Ling ^a   Lee, Yean Jang ^c   Leu, Wohn Jenn ^a   Dong, Yu Shun ^c   Pan, Shiow Lin ^b   Uang, Biing Jiun ^d   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHANGHUA UNIVERSITY OF EDUCATION   (Taiwan)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

apoptosis; castration resistant; Dendrobium; glutathione; mitochondria; prostatic neoplasms

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYTOCHROME C; GLUTATHIONE; MONILIFORMEDIQUINONE; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TROLOX C; UNCLASSIFIED DRUG; CASPASE 2; CASPASE 7; CASPASE 8; DNA A; NATURAL PRODUCT; PACLITAXEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CASTRATION RESISTANT PROSTATE CANCER; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRESS; CELL SYNCHRONIZATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; G1 PHASE CELL CYCLE CHECKPOINT; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; S PHASE CELL CYCLE CHECKPOINT; TUMOR VOLUME; CANCER GROWTH; CANCER SIZE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL LEVEL; CELLULAR STRESS RESPONSE; CYTOTOXICITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL STRESS; MITOCHONDRION; PROSTATE CANCER CELL LINE; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

APOPTOSIS; CASTRATION-RESISTANT; DENDROBIUM; GLUTATHIONE; MITOCHONDRIA; PROSTATIC NEOPLASMS;

ANTINEOPLASTIC AGENTS; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; GLUTATHIONE; HUMANS; MALE; MITOCHONDRIA; PHENANTHRENES; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; QUINONES; TUMOR CELLS, CULTURED;

EID: 84899044681     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.11.102     Document Type: Article

References (30)

1. C. Alifrangis, C. O'Hanlon-Brown, and M. Tuthill et al. New drugs for prostate cancer BJU Int 109 2012 1801
2. M. Lakshminarasimhan, and C. Steegborn Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets Exp Gerontol 46 2011 174
3. V. Gogvadze, S. Orrenius, and B. Zhivotovsky et al. Mitochondria as targets for cancer chemotherapy Semin Cancer Biol 19 2009 57
4. B. Leber, F. Geng, and J. Kale et al. Drugs targeting Bcl-2 family members as an emerging strategy in cancer Expert Rev Mol Med 12 2010 e28
5. C. Garrido, L. Galluzzi, and M. Brunet et al. Mechanisms of cytochrome c release from mitochondria Cell Death Differ 13 2006 1423
6. M. Marí, A. Morales, and A. Colell et al. Mitochondrial glutathione, a key survival antioxidant Antioxid Redox Signal 11 2009 2685
7. J.L. Hsu, S.L. Pan, and Y.F. Ho et al. Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer J Urol 185 2011 1967
8. S. Singh, A.R. Khan, and A.K. Gupta Role of glutathione in cancer pathophysiology and therapeutic interventions J Exp Ther Oncol 9 2012 303
9. D. Hamilton, and G. Batist Glutathione analogues in cancer treatment Curr Oncol Rep 6 2004 116
10. R.L. Singhal, and R. Vijayvargiya Studies on glutathione metabolism in ventral prostate and chemically induced prostatic carcinoma in rats Biosci Rep 3 1983 241
11. S. Thangaraj, W.S. Tsao, and Y.W. Luo et al. Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer Tetrahedron 67 2011 6166
12. P. Skehan, R. Storeng, and D. Scudiero et al. New colorimetric cytotoxicity assay for anticancer-drug screening J Natl Cancer Inst 82 1990 1107
13. P.C. Chiang, S.C. Lin, and S.L. Pan et al. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways Biochem Pharmacol 79 2010 162
14. Y. Liang, S.Y. Lin, and F.C. Brunicardi et al. DNA damage response pathways in tumor suppression and cancer treatment World J Surg 33 2009 661
15. J. Smith, L.M. Tho, and N. Xu et al. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer Adv Cancer Res 108 2010 73
16. I. Vasilevskaya, and P.J. O'Dwyer Role of Jun and Jun kinase in resistance of cancer cells to therapy Drug Resist Updat 6 2003 147
17. Y.C. Chen, P.H. Lu, and J.L. Hsu et al. ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N′-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers Toxicol Appl Pharmacol 257 2011 412
18. B. Zhivotovsky, and S. Orrenius Caspase-2 function in response to DNA damage Biochem Biophys Res Commun 331 2005 859
19. D. De Zio, M. Bordi, and F. Cecconi Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival Int J Cell Biol 2012 2012 752420
20. S. Coppola, and L. Ghibelli GSH extrusion and the mitochondrial pathway of apoptotic signalling Biochem Soc Trans 28 2000 56
21. C. Friesen, Y. Kiess, and K.M. Debatin A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells Cell Death Differ 11 suppl. 2004 S73
22. D.M. Townsend, and K.D. Tew The role of glutathione-S-transferase in anti-cancer drug resistance Oncogene 22 2003 7369
23. B.J. Evison, M. Pastuovic, and R.A. Bilardi et al. M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe Biochem Pharmacol 82 2011 1604
24. H.C. Reinhardt, and M.B. Yaffe Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2 Curr Opin Cell Biol 21 2009 245
25. G.M. Lai, R.F. Ozols, and R.C. Young et al. Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines J Natl Cancer Inst 81 1989 535
26. J. Markovic, J.L. García-Gimenez, and A. Gimeno et al. Role of glutathione in cell nucleus Free Radic Res 44 2010 721
27. J. Markovic, N.J. Mora, and A.M. Broseta et al. The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts PLoS One 4 2009 e6413
28. E. Shaulian AP-1 - the Jun proteins: oncogenes or tumor suppressors in disguise? Cell Signal 22 2010 894
29. E. Bossy-Wetzel, L. Bakiri, and M. Yaniv Induction of apoptosis by the transcription factor c-Jun EMBO J 16 1997 1695
30. S. Leppä, and D. Bohmann Diverse functions of JNK signaling and c-Jun in stress response and apoptosis Oncogene 18 1999 6158