Hepatitis C virus attenuates interferon-induced major histocompatibility complex class i expression and decreases CD8+ T cell effector functions

Gastroenterology

Volumn 146, Issue 5, 2014, Pages

  Kang, Wonseok ^a,b   Sung, Pil Soo ^a   Park, Su Hyung ^c   Yoon, Sarah ^d   Chang, Dong Yeop ^a   Kim, Seungtaek ^b   Han, Kwang Hyub ^b   Kim, Ja Kyung ^b   Rehermann, Barbara ^c   Chwae, Yong Joon ^d   Shin, Eui Cheol ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d Ajou University School of Medicine   (South Korea)

Author keywords

Adaptive Immune Response; Antigen Presentation; Immune Evasion; JFH 1; Keywords

Indexed keywords

HLA A2 ANTIGEN; INITIATION FACTOR 2ALPHA; INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN KINASE R; SHORT HAIRPIN RNA; VIRUS PROTEIN;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COCULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EFFECTOR CELL; FLOW CYTOMETRY; GENE SILENCING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE EVASION; IMMUNOPRECIPITATION; IN VITRO STUDY; INFECTION RATE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; VIRAL CLEARANCE; VIRUS CULTURE;

ADAPTIVE IMMUNE RESPONSE; ANTIGEN PRESENTATION; IMMUNE EVASION; JFH-1;

ADAPTIVE IMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DNA REPLICATION; DNA, VIRAL; DOWN-REGULATION; EIF-2 KINASE; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; GENOTYPE; HEPACIVIRUS; HEPATOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERONS; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84898990603     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.01.054     Document Type: Article

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