Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

Hepatology

Volumn 33, Issue 5, 2001, Pages 1282-1287

  Moradpour, Darius ^a   Grabscheid, Benno ^b   Kammer, Andreas R ^b   Schmidtke, Gunter ^c   Groettrup, Marcus ^c   Blum, Hubert E ^a   Cerny, Andreas ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME; TETRACYCLINE; VIRUS PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VIRUS EXPRESSION; VIRUS MORPHOLOGY; VIRUS VIRULENCE;

EID: 0035028458     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.23793     Document Type: Article

References (42)

1. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus
2. Hepatitis C, the clinical spectrum of disease
3. Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence
4. Interaction between hepatitis C virus and the immune system
5. Possible mechanism involving T lymphocyte response to non structural protein 3 in viral clearance in acute hepatitis C virus infection
6. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
7. Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
8. Analysis of a successful immune response against hepatitis C virus
9. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C
10. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C
11. Analysis of successful immune responses in persons infected with hepatitis C virus
12. Systems to culture hepatitis C virus
13. Viral strategies of immune evasion
14. Viral mechanisms of immune evasion
15. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
16. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein
17. Tightly regulated expression of the entire hepatitis C virus structural region in continuous human cell lines
18. Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
19. Subcellular localization, stability and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines
20. Hepatitis C virus glycoprotein complex localization in the endoplasmic reticulum involves a determinant for retention and not retrieval
21. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
22. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of the PKR-mediated control of protein synthesis
23. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
24. Expression and identification of hepatitis C virus polyprotein cleavage products
25. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
26. Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition
27. Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells
28. Genetic organization and diversity of the hepatitis C virus
29. Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-1 antigen-processing pathway
30. Peptide antigen production by the proteasome: Complexity provides efficiency
31. Inducible expression of the P, V, and NP genes of the paramyxovirus Simian virus 5 in cell lines and an examination of NP-P and NP-V interactions
32. Independent regulation of two separate gene activities in a continuous human cell line
33. The hepatitis C virus NS4A protein: Interactions with the NS4B and NS5A proteins
34. Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B
35. Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein
36. Flavivirus-induced up-regulation of MHC class I antigens; Implications for the induction of CD8+ T-cell-mediated autoimmunity
37. Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product
38. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1
39. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
40. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: Molecular mechanisms of kinase regulation
41. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
42. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein