Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo

Stem Cells

Volumn 32, Issue 5, 2014, Pages 1124-1135

  Stevens, Brett M ^a   Folts, Christopher J ^a   Cui, Wanchang ^a,b   Bardin, Addie L ^a   Walter, Kevin ^a   Carson Walter, Eleanor ^a   Vescovi, Angelo ^c   Noble, Mark ^a,d  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Glioblastoma c Cbl; Redox; Redox Fyn c Cbl pathway; Tumor initiating cell; Tumor initiation

Indexed keywords

ANTIGEN; BETA PIX PROTEIN; CARMUSTINE; CBL PROTEIN; COOL 1 PROTEIN; MEMBRANE PROTEIN; NOTCH1 RECEPTOR; TEMOZOLOMIDE; TRANSCRIPTION FACTOR SOX2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ALKYLATING AGENT; ARHGEF7 PROTEIN, HUMAN; CBL PROTEIN, HUMAN; DACARBAZINE; PROTEIN BINDING; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER RESISTANCE; CARCINOGENESIS; CELL DIVISION; CELL FUNCTION; CONTROLLED STUDY; GENE REPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; TUMOR ASSOCIATED LEUKOCYTE; ANALOGS AND DERIVATIVES; ANIMAL; CANCER STEM CELL; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; MULTICELLULAR SPHEROID; NONOBESE DIABETIC MOUSE; PATHOLOGY; RNA INTERFERENCE; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR VOLUME; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BLOTTING, WESTERN; CARMUSTINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DACARBAZINE; FLOW CYTOMETRY; GLIOBLASTOMA; HEK293 CELLS; HUMANS; MALE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-CBL; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN; TUMOR CELLS, CULTURED;

EID: 84898933319     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1644     Document Type: Article

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