Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth

Nature Cell Biology

Volumn 8, Issue 9, 2006, Pages 945-956

  Feng, Qiyu ^a   Baird, Dan ^a   Peng, Xu ^a   Wang, Jianbin ^a   Ly, Thi ^a   Guan, Jun Lin ^a   Cerione, Richard A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN CDC42; PROTEIN KINASE P60; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL STRAIN 3T3; CELL TRANSFORMATION; COMPLEX FORMATION; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN CELL; MALE; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ENDOCYTOSIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NIH 3T3 CELLS; ONCOGENE PROTEIN PP60(V-SRC); PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 33748136028     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1453     Document Type: Article

References (29)

1. Blume-Jensen, P. & Hunter, T. Oncogenic kinase signalling. Nature 411, 355-365 (2001).
2. Libermann, T. A. et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313, 144-147 (1985).
3. Pavelic, K., Banjac, Z., Pavelic, J. & Spaventi, S. Evidence for a role of EGF receptor in the progression of human lung carcinoma. Anticancer Res. 13, 1133-1137 (1993).
4. Joazeiro, C. A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286, 309-312 (1999).
5. Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/ Sli-1. Mol. Cell 4, 1029-1040 (1999).
6. Waterman, H., Levkowitz, G., Alroy, I. & Yarden, Y. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J. Biol. Chem. 274, 22151-22154 (1999).
7. Duan, L. et al. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J. Biol. Chem. 278, 28950-28960 (2003).
8. Marmor, M. D. & Yarden, Y. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases. Oncogene 23, 2057-2070 (2004).
9. Thien, C. B. & Langdon, W. Y. Cbl: Many adaptations to regulate protein tyrosine kinases. Nature Rev. Mol. Cell Biol. 2, 294-307 (2001).
10. Jiang, X. & Sorkin, A. Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic 4, 529-543 (2003).
11. Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y. & Dikic, I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 416, 183-187 (2002).
12. Wu, W. J., Tu, S. & Cerione, R. A. Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation. Cell 114, 715-725 (2003).
13. Bagrodia, S., Taylor, S. J., Jordon, K. A., Van Aelst, L. & Cerione, R. A. A novel regulator of p21-activated kinases. J. Biol. Chem. 273, 23633-23636 (1998).
14. Manser, E. et al. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192 (1998).
15. Oh, W. K. et al. Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem. Biophys. Res. Commun. 235, 794-798 (1997).
16. Cerione, R. A. & Zheng, Y. The Dbl family of oncogenes. Curr. Opin. Cell Biol. 8, 216-222 (1996).
17. Whitehead, I. P., Campbell, S., Rossman, K. L. & Der, C. J. Dbl family proteins. Biochim. Biophys. Acta. 1332, F1-F23 (1997).
18. Feng, Q., Baird, D. & Cerione, R. A. Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J. 23, 3492-3504 (2004).
19. Baird, D., Feng, Q. & Cerione, R. A. The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade. Curr. Biol. 15, 1-10 (2005).
20. Feng, Q., Albeck, J. G., Cerione, R. A. & Yang, W. Regulation of the Cool/Pix proteins: Key binding partners of the Cdc42/Rac targets, the p21-activated kinases. J. Biol. Chem. 277, 5644-5650 (2002).
21. Flanders, J. A. et al. The Cbl proteins are binding partners for the Cool/Pix family of p21-activated-kinase-binding proteins. FEBS Lett. 550, 119-123 (2003).
22. Guan, J. L. & Shalloway, D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692 (1992).
23. Jozic, D. et al. Cbl promotes clustering of endocytic adaptor proteins. Nature Struct. Mol. Biol. 12, 972-979 (2005).
24. Levitzki, A. & Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267, 1782-1788 (1995).
25. Wilson, L. K. & Parsons, S. J. Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src. Oncogene 5, 1471-1480 (1990).
26. Schmidt, M. H. H., Husnjak, K., Szymkiewicz, I., Haglund, K. & Dikic, I. Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecules bPix. Oncogene 25, 3071-3078 (2006).
27. Johnson, P. J., Coussens, P. M., Danko, A. V. & Shalloway, D. Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells. Mol. Cell Biol. 5, 1073-1083 (1985).
28. Park, H. S. et al. Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol. Cell Biol. 24, 4384-4394 (2004).
29. Melkoumian, Z. K., Peng, X., Gan, B., Wu, X. & Guan, J. L. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res. 65, 6676-6684 (2005).