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Volumn 52, Issue 3, 2014, Pages 311-319

An invertebrate model to evaluate virulence in Aspergillus fumigatus: The role of azole resistance

Author keywords

cyp51A gene; isogenic mutants; Nonmammalian model

Indexed keywords

ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE;

EID: 84898910571     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1093/mmy/myt022     Document Type: Article
Times cited : (34)

References (30)
  • 1
    • 21344451158 scopus 로고    scopus 로고
    • Evolution of antifungal-drug resistance: Mechanisms and pathogen fitness
    • Anderson JB. Evolution of antifungal-drug resistance: Mechanisms and pathogen fitness. Nat Rev Microbiol 2005; 3: 547-556.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 547-556
    • Anderson, J.B.1
  • 2
    • 13244298189 scopus 로고    scopus 로고
    • Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma
    • Chen J, Li H, Li R, Bu D,Wan Z. Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma. J Antimicrob Chemother 2005; 55: 31-37.
    • (2005) J Antimicrob Chemother , vol.55 , pp. 31-37
    • Chen, J.1    Li, H.2    Li, R.3    Bu Dwan, Z.4
  • 3
    • 0037417050 scopus 로고    scopus 로고
    • A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus
    • Diaz-Guerra TM, Mellado E, Cuenca-Estrella M, Rodriguez-Tudela JL. A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus. Antimicrob Agents Chemother 2003; 47: 1120-1124.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1120-1124
    • Diaz-Guerra, T.M.1    Mellado, E.2    Cuenca-Estrella, M.3    Rodriguez-Tudela, J.L.4
  • 4
    • 3042531281 scopus 로고    scopus 로고
    • Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs
    • Mellado E, Garcia-Effron G, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL. Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs. Antimicrob Agents Chemother 2004; 48: 2747-2750.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2747-2750
    • Mellado, E.1    Garcia-Effron, G.2    Alcazar-Fuoli, L.3    Cuenca-Estrella, M.4    Rodriguez-Tudela, J.L.5
  • 5
    • 19544388244 scopus 로고    scopus 로고
    • Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility
    • Mellado E, Garcia-Effron G, Buitrago MJ et al. Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility. Antimicrob Agents Chemother 2005; 49: 2536-2538.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2536-2538
    • Mellado, E.1    Garcia-Effron, G.2    Buitrago, M.J.3
  • 6
    • 34250223076 scopus 로고    scopus 로고
    • A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations
    • Mellado E, Garcia-Effron G, Alcazar-Fuoli L et al. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob Agents Chemother 2007; 51: 1897-1904.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1897-1904
    • Mellado, E.1    Garcia-Effron, G.2    Alcazar-Fuoli, L.3
  • 7
  • 8
    • 67650657544 scopus 로고    scopus 로고
    • Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure
    • Howard SJ, Cerar D, Anderson MJ et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 2009; 15: 1068-1076.
    • (2009) Emerg Infect Dis , vol.15 , pp. 1068-1076
    • Howard, S.J.1    Cerar, D.2    Anderson, M.J.3
  • 9
    • 77956302523 scopus 로고    scopus 로고
    • Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence
    • Arendrup MC, Mavridou E, Mortensen KL et al. Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence. PLoS One 2010; 5: E10080.
    • (2010) PLoS One , vol.5
    • Arendrup, M.C.1    Mavridou, E.2    Mortensen, K.L.3
  • 10
    • 22844434430 scopus 로고    scopus 로고
    • The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence
    • Clemons KV, Stevens DA. The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence. Med Mycol 2005; 43 (Suppl 1): S101-S110.
    • (2005) Med Mycol , vol.43 , Issue.SUPPL. 1
    • Clemons, K.V.1    Stevens, D.A.2
  • 11
    • 1242351240 scopus 로고    scopus 로고
    • Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens
    • Kavanagh K, Reeves EP. Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens. FEMS Microbiol Rev 2004; 28: 101-112.
    • (2004) FEMS Microbiol Rev , vol.28 , pp. 101-112
    • Kavanagh, K.1    Reeves, E.P.2
  • 12
    • 0034913684 scopus 로고    scopus 로고
    • Vertebrate innate immunity resembles a mosaic of invertebrate immune responses
    • Salzet M. Vertebrate innate immunity resembles a mosaic of invertebrate immune responses. Trends Immunol 2001; 22: 285-288.
    • (2001) Trends Immunol , vol.22 , pp. 285-288
    • Salzet, M.1
  • 13
    • 0037063976 scopus 로고    scopus 로고
    • Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae
    • Brennan M, Thomas DY, Whiteway M, Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunol Med Microbiol 2002; 34: 153-157.
    • (2002) FEMS Immunol Med Microbiol , vol.34 , pp. 153-157
    • Brennan, M.1    Thomas, D.Y.2    Whiteway, M.3    Kavanagh, K.4
  • 14
    • 21544439035 scopus 로고    scopus 로고
    • Worms and flies as genetically tractable animal models to study host-pathogen interactions
    • Mylonakis E, Aballay A.Worms and flies as genetically tractable animal models to study host-pathogen interactions. Infect Immun 2005; 73: 3833-3841.
    • (2005) Infect Immun , vol.73 , pp. 3833-3841
    • Mylonakis, E.1    Aballay, A.2
  • 15
    • 38549111944 scopus 로고    scopus 로고
    • Galleria mellonella and the study of fungal pathogenesis: Making the case for another genetically tractable model host
    • Mylonakis E. Galleria mellonella and the study of fungal pathogenesis: Making the case for another genetically tractable model host. Mycopathologia 2008; 165: 1-3.
    • (2008) Mycopathologia , vol.165 , pp. 1-3
    • Mylonakis, E.1
  • 16
    • 4444297435 scopus 로고    scopus 로고
    • Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella
    • Reeves EP, Messina CG, Doyle S, Kavanagh K. Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella. Mycopathologia 2004; 158: 73-79.
    • (2004) Mycopathologia , vol.158 , pp. 73-79
    • Reeves, E.P.1    Messina, C.G.2    Doyle, S.3    Kavanagh, K.4
  • 17
    • 33745020068 scopus 로고    scopus 로고
    • Susceptibility of larvae of Galleria mellonella to infection by Aspergillus fumigatus is dependent upon stage of conidial germination
    • Renwick J, Daly P, Reeves EP, Kavanagh K. Susceptibility of larvae of Galleria mellonella to infection by Aspergillus fumigatus is dependent upon stage of conidial germination. Mycopathologia 2006; 161: 377-384.
    • (2006) Mycopathologia , vol.161 , pp. 377-384
    • Renwick, J.1    Daly, P.2    Reeves, E.P.3    Kavanagh, K.4
  • 19
    • 0141992945 scopus 로고    scopus 로고
    • Use of turbidimetric growth curves for early determination of antifungal drug resistance of filamentous fungi
    • Meletiadis J, te Dorsthorst DT, Verweij PE. Use of turbidimetric growth curves for early determination of antifungal drug resistance of filamentous fungi. J Clin Microbiol 2003; 41: 4718-4725.
    • (2003) J Clin Microbiol , vol.41 , pp. 4718-4725
    • Meletiadis, J.1    Te Dorsthorst, D.T.2    Verweij, P.E.3
  • 21
    • 78049318458 scopus 로고    scopus 로고
    • Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria Denmark and Spain
    • Mortensen KL, Mellado E, Lass-Florl C et al. Environmental study of azole-resistant Aspergillus fumigatus and other aspergilli in Austria, Denmark, and Spain. Antimicrob Agents Chemother 2010; 54: 4545-4549.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4545-4549
    • Mortensen, K.L.1    Mellado, E.2    Lass-Florl, C.3
  • 22
    • 75749102569 scopus 로고    scopus 로고
    • Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene
    • Mavridou E, Bruggemann RJ, Melchers WJ, Mouton JW, Verweij PE. Efficacy of posaconazole against three clinical Aspergillus fumigatus isolates with mutations in the cyp51A gene. Antimicrob Agents Chemother 2010; 54: 860-865.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 860-865
    • Mavridou, E.1    Bruggemann, R.J.2    Melchers, W.J.3    Mouton, J.W.4    Verweij, P.E.5
  • 23
    • 79951500577 scopus 로고    scopus 로고
    • Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice
    • Slater JL, Gregson L, Denning DW, Warn PA. Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice. Med Mycol 2011; 49 (Suppl 1): S107-S113.
    • (2011) Med Mycol , vol.49 , Issue.SUPPL. 1
    • Slater, J.L.1    Gregson, L.2    Denning, D.W.3    Warn, P.A.4
  • 25
    • 0032819255 scopus 로고    scopus 로고
    • Presence of IL-1-and TNF-like molecules in Galleria mellonella (Lepidoptera) haemocytes and in an insect cell line Fromestigmene acraea (Lepidoptera)
    • Wittwer D, Franchini A, Ottaviani E,Wiesner A. Presence of IL-1-and TNF-like molecules in Galleria mellonella (Lepidoptera) haemocytes and in an insect cell line Fromestigmene acraea (Lepidoptera). Cytokine 1999; 11: 637-642.
    • (1999) Cytokine , vol.11 , pp. 637-642
    • Wittwer, D.1    Franchini, A.2    Ottaviani, E.3    Wiesner, A.4
  • 27
    • 84879573848 scopus 로고    scopus 로고
    • Fungal virulence in a lepidopteran model is an emergent property with deterministic features
    • Garcia-Solache MA, Izquierdo-Garcia D, Smith C, Bergman A, Casadevall A. Fungal virulence in a lepidopteran model is an emergent property with deterministic features. MBio 2013; 4: E00100-e00113.
    • (2013) MBio , vol.4
    • Garcia-Solache, M.A.1    Izquierdo-Garcia, D.2    Smith, C.3    Bergman, A.4    Casadevall, A.5
  • 28
    • 84879926068 scopus 로고    scopus 로고
    • The non-mammalian host Galleria mellonella can be used to study the virulence of the fungal pathogen Candida tropicalis and the efficacy of antifungal drugs during infection by this pathogenic yeast
    • Mesa-Arango AC, Forastiero A, Bernal-Martinez L et al. The non-mammalian host Galleria mellonella can be used to study the virulence of the fungal pathogen Candida tropicalis and the efficacy of antifungal drugs during infection by this pathogenic yeast. Med Mycol 2013; 51: 461-472.
    • (2013) Med Mycol , vol.51 , pp. 461-472
    • Mesa-Arango, A.C.1    Forastiero, A.2    Bernal-Martinez, L.3
  • 29
    • 0022255535 scopus 로고
    • Invertebrate immunity-A primer for the nonspecialist
    • Ratcliffe NA. Invertebrate immunity-A primer for the nonspecialist. Immunol Lett 1985; 10: 253-270.
    • (1985) Immunol Lett , vol.10 , pp. 253-270
    • Ratcliffe, N.A.1
  • 30
    • 0345096508 scopus 로고    scopus 로고
    • Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella
    • Bergin D, Brennan M, Kavanagh K. Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella. Microbes Infect 2003; 5: 1389-1395.
    • (2003) Microbes Infect , vol.5 , pp. 1389-1395
    • Bergin, D.1    Brennan, M.2    Kavanagh, K.3


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