Development of azole resistance in aspergillus fumigatus during azole therapy associated with change in virulence

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Arendrup, Maiken Cavling ^a   Mavridou, Eleftheria ^b   Mortensen, Klaus Leth ^a   Snelders, Eveline ^b   Frimodt Møller, Niels ^a   Khan, Humara ^c   Melchers, Willem J G ^b   Verweij, Paul E ^c  

^a STATENS SERUM INSTITUT   (Denmark)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ESBJERG HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANIDULAFUNGIN; CASPOFUNGIN; CYTOCHROME P450; CYTOCHROME P450 51A; ECHINOCANDIN; ITRACONAZOLE; POSACONAZOLE; UNCLASSIFIED DRUG; VORICONAZOLE; ANTIFUNGAL AGENT; PYRROLE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLUS FUMIGATUS; CASE REPORT; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; DRUG TREATMENT FAILURE; FUNGAL GENE; FUNGAL MORPHOLOGY; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS ISOLATION; GENE EXPRESSION; GENOTYPE; HUMAN; INVASIVE ASPERGILLOSIS; LUNG ASPERGILLOSIS; LUNG FIBROSIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SPUTUM CULTURE; SURVIVAL RATE; ANIMAL; DRUG COMBINATION; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOGENICITY; VIRULENCE;

ASPERGILLUS FUMIGATUS; MUS;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZOLES; DRUG RESISTANCE, FUNGAL; DRUG THERAPY, COMBINATION; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; MICE; VIRULENCE;

EID: 77956302523     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010080     Document Type: Article

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