Looking back, to the future of circulating tumor cells

Pharmacology and Therapeutics

Volumn 142, Issue 3, 2014, Pages 271-280

  Friedlander, Terence W ^a   Premasekharan, Gayatri ^b   Paris, Pamela L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CellSearch; Circulating tumor cells; EpCAM; Epithelial to mesenchymal transition; Stem cells

Indexed keywords

BIOLOGICAL MARKER; TUMOR MARKER;

APOPTOSIS; BASEMENT MEMBRANE; BREAST TUMOR; CANCER GROWTH; CANCER STEM CELL; CELL INVASION; CELL ISOLATION; CELL SELECTION; CELL SIZE; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CIRCULATING TUMOR CELL; CULTURAL ANTHROPOLOGY; EPITHELIAL MESENCHYMAL TRANSITION; GENOMICS; HUMAN; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; METASTASIS; NONHUMAN; PATHOGENESIS; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; REVIEW; RNA SEQUENCE; SINGLE CELL ANALYSIS; SURVIVAL; TUMOR CELL; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; CELL COUNT; CELL SEPARATION; CLINICAL TRIAL (TOPIC); CULTURE TECHNIQUE; TUMOR EMBOLISM;

ANIMALS; BIOMARKERS, TUMOR; CELL COUNT; CELL CULTURE TECHNIQUES; CELL SEPARATION; CLINICAL TRIALS AS TOPIC; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; NEOPLASTIC CELLS, CIRCULATING;

EID: 84898906740     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.12.011     Document Type: Review

References (120)

1. B. Aktas, M. Tewes, T. Fehm, S. Hauch, R. Kimmig, and S. Kasimir-Bauer Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients Breast Cancer Res 11 2009 R46
2. M. Al-Hajj, M.S. Wicha, A. Benito-Hernandez, S.J. Morrison, and M.F. Clarke Prospective identification of tumorigenic breast cancer cells Proc Natl Acad Sci U S A 100 2003 3983 3988 (Pubitemid 36418143)
3. C. Alix-Panabières, J.-P. Brouillet, M. Fabbro, H. Yssel, T. Rousset, and T. Maudelonde et al. Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients J Immunol Methods 299 2005 177 188 (Pubitemid 40725934)
4. W.J. Allard, J. Matera, M.C. Miller, M. Repollet, M.C. Connelly, and C. Rao et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases Clin Cancer Res 10 2004 6897 6904 (Pubitemid 39383039)
5. A.J. Armstrong, M.S. Marengo, S. Oltean, G. Kemeny, R.L. Bitting, and J.D. Turnbull et al. Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers Mol Cancer Res 9 2011 997 1007
6. T.R. Ashworth A case of cancer in which cells similar to those in the tumours were seen in the blood after death Med J Aust 14 1869 146 149
7. G. Attard, and J.S. de Bono Utilizing circulating tumor cells: challenges and pitfalls Curr Opin Genet Dev 21 2011 50 58
8. I. Baccelli, A. Schneeweiss, S. Riethdorf, A. Stenzinger, A. Schillert, and V. Vogel et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay Nat Biotechnol 31 2013 539 544
9. M.K. Baker, K. Mikhitarian, W. Osta, K. Callahan, R. Hoda, and F. Brescia et al. Molecular detection of breast cancer cells in the peripheral blood of advanced-stage breast cancer patients using multimarker real-time reverse transcription-polymerase chain reaction and a novel porous barrier density gradient centrifugation technology Clin Cancer Res 9 2003 4865 4871 (Pubitemid 37323291)
10. P. Balasubramanian, J.C. Lang, K.R. Jatana, B. Miller, E. Ozer, and M. Old et al. Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck PLoS One 7 2012 e42048
11. M. Balic, N. Dandachi, G. Hofmann, H. Samonigg, H. Loibner, and A. Obwaller et al. Comparison of two methods for enumerating circulating tumor cells in carcinoma patients Cytometry B Clin Cytom 68B 2005 25 30 (Pubitemid 41566360)
12. N. Benali-Furet, F. Ye, S. Ezaoui, M. Avril, F. Boitier, and A. Carlotti et al. Ex vivo expansion of CTCs in culture isolated by size from patients with melanoma 9th Annual Internation Symposium on Minimal Residual Cancer. Paris 2013
13. G. Berx, E. Raspe, G. Christofori, J.P. Thiery, and J.P. Sleeman Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer Clin Exp Metastasis 24 2007 587 597 (Pubitemid 50000849)
14. U. Bilkenroth, H. Taubert, D. Riemann, U. Rebmann, H. Heynemann, and A. Meye Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation Int J Cancer 92 2001 577 582 (Pubitemid 32319433)
15. G.T. Budd, M. Cristofanilli, M.J. Ellis, A. Stopeck, E. Borden, and M.C. Miller et al. Circulating tumor cells versus imaging-predicting overall survival in metastatic breast cancer Clin Cancer Res 12 2006 6403 6409 (Pubitemid 44799711)
16. O. Camara, A. Kavallaris, H. Noschel, M. Rengsberger, C. Jorke, and K. Pachmann Seeding of epithelial cells into circulation during surgery for breast cancer: the fate of malignant and benign mobilized cells World J Surg Oncol 4 2006 67
17. T. Cangiano, J. Liao, J. Naitoh, F. Dorey, R. Figlin, and A. Belldegrun Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy J Clin Oncol 17 1999 523 528 (Pubitemid 29075238)
18. G.M. Cann, Z.G. Gulzar, S. Cooper, R. Li, S. Luo, and M. Tat et al. mRNA-Seq of single prostate cancer circulating tumor cells reveals recapitulation of gene expression and pathways found in prostate cancer PLoS One 7 2012 e49144
19. Z. Cao, B. Shang, G. Zhang, L. Miele, F.H. Sarkar, and Z. Wang et al. Tumor cell-mediated neovascularization and lymphangiogenesis contrive tumor progression and cancer metastasis Biochim Biophys Acta 1836 2013 273 286
20. B.P. Casavant, R. Mosher, J.W. Warrick, L.J. Maccoux, S.M.F. Berry, and J.T. Becker et al. A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells Methods 2013
21. H.C. Chen, Y.T. Zhu, S.Y. Chen, and S.C. Tseng Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition Lab Invest 92 2012 676 687
22. S.J. Cohen, C.J. Punt, N. Iannotti, B.H. Saidman, K.D. Sabbath, and N.Y. Gabrail et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer J Clin Oncol 26 2008 3213 3221
23. J. Comijn, G. Berx, P. Vermassen, K. Verschueren, L. van Grunsven, and E. Bruyneel et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion Mol Cell 7 2001 1267 1278 (Pubitemid 32607360)
24. M. Cristofanilli, G.T. Budd, M.J. Ellis, A. Stopeck, J. Matera, and M.C. Miller et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer N Engl J Med 351 2004 781 791 (Pubitemid 39095313)
25. S.J. Dawson, D.W. Tsui, M. Murtaza, H. Biggs, O.M. Rueda, and S.F. Chin et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer N Engl J Med 368 2013 1199 1209
26. J.S. De Bono, H.I. Scher, R.B. Montgomery, C. Parker, M.C. Miller, and H. Tissing et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer Clin Cancer Res 14 2008 6302 6309
27. I. Desitter, B.S. Guerrouahen, N. Benali-Furet, J. Wechsler, P.A. Jänne, and Y. Kuang et al. A New Device for Rapid Isolation by Size and Characterization of Rare Circulating Tumor Cells Anticancer Res 31 2011 427 441
28. L.A. Diaz Jr., R.T. Williams, J. Wu, I. Kinde, J.R. Hecht, and J. Berlin et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers Nature 486 2012 537 540
29. T. Fan, Q. Zhao, J.J. Chen, W.T. Chen, and M.L. Pearl Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer Gynecol Oncol 112 2009 185 191
30. I.J. Fidler The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis Eur J Cancer 9 1973 223 227
31. B. Franken, M.R. de Groot, W.J. Mastboom, I. Vermes, J. van der Palen, and A.G. Tibbe et al. Circulating tumor cells, disease recurrence and survival in newly diagnosed breast cancer Breast Cancer Res 14 2012 R133
32. T.W. Friedlander, V.T. Ngo, H. Dong, G. Premasekharan, V. Weinberg, and S. Doty et al. Detection and characterization of invasive circulating tumor cells (ictcs) derived from men with metastatic castration resistant prostate cancer (mCRPC) Int J Cancer 2013 (in press, epub ahead of print)
33. P.R.C. Gascoyne, J. Noshari, T.J. Anderson, and F.F. Becker Isolation of rare cells from cell mixtures by dielectrophoresis Electrophoresis 30 2009 1388 1398
34. S. Giordano, A. Maffe, T.A. Williams, S. Artigiani, P. Gual, and A. Bardelli et al. Different point mutations in the met oncogene elicit distinct biological properties Faseb J 14 2000 399 406 (Pubitemid 30086077)
35. A. Gradilone, C. Raimondi, C. Nicolazzo, A. Petracca, O. Gandini, and B. Vincenzi et al. Circulating tumour cells lacking cytokeratin in breast cancer: the importance of being mesenchymal J Cell Mol Med 15 2011 1066 1070
36. V. Gupta, I. Jafferji, M. Garza, V.O. Melnikova, D.K. Hasegawa, and R. Pethig et al. ApoStream, a new dielectrophoretic device for antibody independent isolation and recovery of viable cancer cells from blood Biomicrofluidics 6 2012
37. D.F. Hayes, M. Cristofanilli, G.T. Budd, M.J. Ellis, A. Stopeck, and M.C. Miller et al. Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival Clin Cancer Res 12 2006 4218 4224
38. W. He, S.A. Kularatne, K.R. Kalli, F.G. Prendergast, R.J. Amato, and G.G. Klee et al. Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands Int J Cancer 123 2008 1968 1973
39. K.T. Helzer, H.E. Barnes, L. Day, J. Harvey, P.R. Billings, and A. Forsyth Circulating tumor cells are transcriptionally similar to the primary tumor in a murine prostate model Cancer Res 69 2009 7860 7866
40. C. Hodgkinson, C. Morrow, R. Metcalf, L. Carter, D. Nonaka, and D. Rothwell et al. The identification of circulating micro-RNAs (miRNA) to monitor tumour burden in mice bearing small cell lung cancer (SCLC) xenografts established from patient derived circulating tumour cells (CTCs) 9th International Symposium on Minimal Residual Cancer. Paris 2013
41. H.B. Hsieh, D. Marrinucci, K. Bethel, D.N. Curry, M. Humphrey, and R.T. Krivacic et al. High speed detection of circulating tumor cells Biosens Bioelectron 21 2006 1893 1899
42. A.D. Hughes, J. Mattison, J.D. Powderly, B.T. Greene, and M.R. King Rapid isolation of viable circulating tumor cells from patient blood samples J Vis Exp 2012 e4248
43. H. Iinuma, T. Watanabe, K. Mimori, M. Adachi, N. Hayashi, and J. Tamura et al. Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer J Clin Oncol 29 2011 1547 1555
44. I. Ivanov, J. Stojcic, A. Stanimirovic, E. Sargent, R.K. Nam, and S.O. Kelley Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples Anal Chem 85 2012 398 403
45. G. Kallergi, M.A. Papadaki, E. Politaki, D. Mavroudis, V. Georgoulias, and S. Agelaki Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients Breast Cancer Res 13 2011 R59
46. S. Kasimir-Bauer, O. Hoffmann, D. Wallwiener, R. Kimmig, and T. Fehm Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells Breast Cancer Res 14 2012 R15
47. S. Kim, S.I. Han, M.J. Park, C.W. Jeon, Y.D. Joo, and I.H. Choi et al. Circulating tumor cell microseparator based on lateral magnetophoresis and immunomagnetic nanobeads Anal Chem 85 2013 2779 2786
48. B.J. Kirby, M. Jodari, M.S. Loftus, G. Gakhar, E.D. Pratt, and C. Chanel-Vos et al. Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device PLoS One 7 2012 e35976
49. T. Kojima, Y. Hashimoto, Y. Watanabe, S. Kagawa, F. Uno, and S. Kuroda et al. A simple biological imaging system for detecting viable human circulating tumor cells J Clin Invest 119 2009 3172 3181
50. M.I. Kokkinos, R. Wafai, M.K. Wong, D.F. Newgreen, E.W. Thompson, and M. Waltham Vimentin and epithelial-mesenchymal transition in human breast cancer-observations in vitro and in vivo Cells Tissues Organs 185 2007 191 203 (Pubitemid 46957486)
51. R.T. Krivacic, A. Ladanyi, D.N. Curry, H.B. Hsieh, P. Kuhn, and D.E. Bergsrud et al. A rare-cell detector for cancer Proc Natl Acad Sci U S A 101 2004 10501 10504 (Pubitemid 38955770)
52. P.A. Liberti, C.G. Rao, and L.W.M.M. Terstappen Optimization of ferrofluids and protocols for the enrichment of breast tumor cells in blood J Magn Magn Mater 225 2001 301 307 (Pubitemid 32335309)
53. H.-C. Lin, H.-C. Hsu, C.-H. Hsieh, H.-M. Wang, C.-Y. Huang, and W. Min-Hsien et al. A negative selection system PowerMag for effective leukocyte depletion and enhanced detection of EpCAM positive and negative circulating tumor cells Clin Chim Acta 419 2013 77 84
54. H.K. Lin, S. Zheng, A.J. Williams, M. Balic, S. Groshen, and H.I. Scher et al. Portable Filter-Based Microdevice for Detection and Characterization of Circulating Tumor Cells Clin Cancer Res 16 2010 5011 5018
55. Z. Liu, A. Fusi, E. Klopocki, A. Schmittel, I. Tinhofer, and A. Nonnenmacher et al. Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients J Transl Med 9 2011 70
56. J. Lu, T. Fan, Q. Zhao, W. Zeng, E. Zaslavsky, and J.J. Chen et al. Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients Int J Cancer 126 2010 669 683
57. Y.-T. Lu, L. Zhao, Q. Shen, M.A. Garcia, D. Wu, and S. Hou et al. NanoVelcro Chip for CTC enumeration in prostate cancer patients Methods 2013
58. M. Mego, S.A. Mani, B.N. Lee, C. Li, K.W. Evans, and E.N. Cohen et al. Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy Int J Cancer 130 2012 808 816
59. M. Mego, M. Mego, M. Mego, S. Mani, C. Li, and E. Andreoupolou et al. Circulating Tumor Cells (CTCs) and Epithelial Mesenchymal Transition (EMT) in Breast Cancer: Describing the Heterogeneity of Microscopic Disease Thirty-Second Annual CTRC-AACR San Antonio Breast Cancer Symposium 2009 San Antonio, TX USA
60. A. Meye, U. Bilkenroth, U. Schmidt, S. Fussel, K. Robel, and A.M. Melchior et al. Isolation and enrichment of urologic tumor cells in blood samples by a semi-automated CD45 depletion autoMACS protocol Int J Oncol 21 2002 521 530
61. C. Mihalcioiu CTC collection via apheresis with ability to culture and grow in mice 9th Annual Internation Symposium on Minimal Residual Cancer. Paris 2013
62. D.T. Miyamoto, R.J. Lee, S.L. Stott, D.T. Ting, B.S. Wittner, and M. Ulman et al. Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer Cancer Discov 2 2012 995 1003
63. B. Molnar, A. Ladanyi, L. Tanko, L. Sreter, and Z. Tulassay Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients Clin Cancer Res 7 2001 4080 4085 (Pubitemid 34044631)
64. J.G. Moreno, S.M. O'Hara, S. Gross, G. Doyle, H. Fritsche, and L.G. Gomella et al. Changes in circulating carcinoma cells in patients with metastatic prostate cancer correlate with disease status Urology 58 2001 386 392 (Pubitemid 32816356)
65. T.M. Morgan, P.H. Lange, and R.L. Vessella Detection and characterization of circulating and disseminated prostate cancer cells Front Biosci 12 2007 3000 3009
66. V. Muller, S. Riethdorf, B. Rack, W. Janni, P.A. Fasching, and E. Solomayer et al. Prognostic impact of circulating tumor cells assessed with the CellSearch System and AdnaTest Breast in metastatic breast cancer patients: the DETECT study Breast Cancer Res 14 2012 R118
67. M. Murtaza, S.J. Dawson, D.W. Tsui, D. Gale, T. Forshew, and A.M. Piskorz et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA Nature 497 2013 108 112
68. P.C. Nowell The clonal evolution of tumor cell populations Science 194 1976 23 28
69. M. Oft, J. Peli, C. Rudaz, H. Schwarz, H. Beug, and E. Reichmann TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells Genes Dev 10 1996 2462 2477 (Pubitemid 26341881)
70. C.A. Olsson, G.M. de Vries, A.J. Raffo, M.C. Benson, K. O'Toole, and Y. Cao et al. Preoperative Reverse Transcriptase Polymerase Chain Reaction for Prostate Specific Antigen Predicts Treatment Failure Following Radical Prostatectomy J Urol 155 1996 1557 1562 (Pubitemid 26126948)
71. E. Ozkumur, A.M. Shah, J.C. Ciciliano, B.L. Emmink, D.T. Miyamoto, and E. Brachtel et al. Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells Sci Transl Med 5 2013 179ra147
72. P.L. Paris, Y. Kobayashi, Q. Zhao, W. Zeng, S. Sridharan, and T. Fan et al. Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer Cancer Lett 277 2009 164 173
73. S. Park, B. Lee, I. Kim, I. Choi, K. Hong, and Y. Ryu et al. Immunobead RT-PCR versus regular RT-PCR amplification of CEA mRNA in peripheral blood J Cancer Res Clin Oncol 127 2001 489 494 (Pubitemid 32662506)
74. A. Parker, S. W. E. White, F. Juhn, G. Otto, and G. Frampton et al. Profiling the tumor genome using circulating tumor cells Advances in Genome Biology and Technology (AGBT) 2012
75. M. Partridge, E. Phillips, R. Francis, and S.R. Li Immunomagnetic separation for enrichment and sensitive detection of disseminated tumour cells in patients with head and neck SCC J Pathol 189 1999 368 377 (Pubitemid 29489222)
76. P. Paterlini-Brechot, and N.L. Benali Circulating tumor cells (CTC) detection: Clinical impact and future directions Cancer Lett 253 2007 180 204 (Pubitemid 47017533)
77. D.J. Peeters, B. De Laere, G.G. Van den Eynden, S.J. Van Laere, F. Rothe, and M. Ignatiadis et al. Semiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting Br J Cancer 108 2013 1358 1367
78. K. Polyak, and W.C. Hahn Roots and stems: stem cells in cancer Nat Med 12 2006 296 300 (Pubitemid 43355075)
79. K. Polyak, and R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat Rev Cancer 9 2009 265 273
80. R.L. Prentice Surrogate endpoints in clinical trials: definition and operational criteria Stat Med 8 1989 431 440 (Pubitemid 19105891)
81. E. Punnoose, T. E. D. Marrinucci, C.L. Amler, H. Koeppen, and P.H. Patel et al. Evaluation of PTEN status in circulating tumor cells (CTCs) and matched tumor tissue from patients with castrate-resistant prostate cancer (CRPC) American Society of Clinical Oncology (ASCO) 2013
82. S. Riethdorf, V. Muller, L. Zhang, T. Rau, S. Loibl, and M. Komor et al. Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial Clin Cancer Res 16 2010 2634 2645
83. A.C. Sabuncu, J.A. Liu, S.J. Beebe, and A. Beskok Dielectrophoretic separation of mouse melanoma clones Biomicrofluidics 4 2010
84. P. Savagner The epithelial-mesenchymal transition (EMT) phenomenon Ann Oncol 21 Suppl. 7 2010 vii89 vii92
85. H. Scher, G. Heller, and A. Molina Evaluation of a composite biomarker panel including circulating tumor cell enumeration as a surrogate for survival in metastatic castration-resistant prostate cancer 2013 European Cancer Congress Amsterdam, The Netherlands
86. H.I. Scher, G. Heller, A. Molina, T.S. Kheoh, G. Attard, and J. Moreira et al. Evaluation of circulating tumor cell (CTC) enumeration as an efficacy response biomarker of overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC): Planned final analysis (FA) of COU-AA-301, a randomized, double-blind, placebo-controlled, phase III study of abiraterone acetate (AA) plus low-dose prednisone (P) post docetaxel J Clin Oncol 29 2011
87. H.I. Scher, X. Jia, J.S. de Bono, M. Fleisher, K.J. Pienta, and D. Raghavan et al. Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data Lancet Oncol 10 2009 233 239
88. M. Schwab Encyclopedia of Cancer: SpringerReference In 2009 Springer-Verlag Berlin Heidelberg
89. G.L. Semenza Molecular mechanisms mediating metastasis of hypoxic breast cancer cells Trends Mol Med 18 2012 534 543
90. S. Shim, K. Stemke-Hale, A.M. Tsimberidou, J. Noshari, T.E. Anderson, and P.R.C. Gascoyne Antibody-independent isolation of circulating tumor cells by continuous-flow dielectrophoresis Biomicrofluidics 7 2013 011807
91. D. Shook, and R. Keller Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development Mech Dev 120 2003 1351 1383 (Pubitemid 37421168)
92. S. Sieben, C. Bergemann, A. Lübbe, B. Brockmann, and D. Rescheleit Comparison of different particles and methods for magnetic isolation of circulating tumor cells J Magn Magn Mater 225 2001 175 179 (Pubitemid 32335293)
93. S.K. Singh, C. Hawkins, I.D. Clarke, J.A. Squire, J. Bayani, and T. Hide et al. Identification of human brain tumour initiating cells Nature 432 2004 396 401 (Pubitemid 39551674)
94. M. Smalley, and A. Ashworth Stem cells and breast cancer: A field in transit Nat Rev Cancer 3 2003 832 844 (Pubitemid 37376981)
95. A. Strati, A. Markou, C. Parisi, E. Politaki, D. Mavroudis, and V. Georgoulias et al. Gene expression profile of circulating tumor cells in breast cancer by RT-qPCR BMC Cancer 11 2011 422
96. A. Stresemann, F. J. D. Niederacher, K. Raba, A. Schmitz, and M. Schwartz et al. A comprehensive comparison study: Capturing of CTCs by different technologies followed by molecular analysis Advances in Circulating Tumor Cells 2012
97. W. Tang, X. Hao, F. H. L. Li, and L. Xu Anti-CD44 antibody treatment inhibits pancreatic cancer metastasis and post-radiotherapy recurrence Cancer Res 71 2011
98. M. Thalgott, B. Rack, T. Maurer, M. Souvatzoglou, M. Eiber, and V. Kreß et al. Detection of circulating tumor cells in different stages of prostate cancer J Cancer Res Clin Oncol 139 2013 755 763
99. P.A. Theodoropoulos, H. Polioudaki, S. Agelaki, G. Kallergi, Z. Saridaki, and D. Mavroudis et al. Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer Cancer Lett 288 2010 99 106
100. K.H. Tkaczuk, O. Goloubeva, N.S. Tait, F. Feldman, M. Tan, and Z.P. Lum et al. The significance of circulating epithelial cells in Breast Cancer patients by a novel negative selection method Breast Cancer Res Treat 111 2008 355 364
101. A. Vincent-Salomon, and J.P. Thiery Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development Breast Cancer Res 5 2003 101 106 (Pubitemid 36348104)
102. G. Vona, L. Estepa, C. Béroud, D. Damotte, F. Capron, and B. Nalpas et al. Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer Hepatology 39 2004 792 797 (Pubitemid 38337659)
103. G. Vona, A. Sabile, M. Louha, V. Sitruk, S. Romana, and K. Schutze et al. Isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells Am J Pathol 156 2000 57 63 (Pubitemid 30644439)
104. L. Wang, W. Su, Z. Liu, M. Zhou, S. Chen, and Y. Chen et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma Biomaterials 33 2012 5107 5114
105. M.E. Warkiani, G. Guan, K.B. Luan, W.C. Lee, A.A.S. Bhagat, and P. Kant Chaudhuri et al. Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells Lab Chip 2014
106. S. Watanabe The metastasizability of tumor cells Cancer 7 1954 215 223
107. P.T. Went, A. Lugli, S. Meier, M. Bundi, M. Mirlacher, and G. Sauter et al. Frequent EpCam protein expression in human carcinomas Hum Pathol 35 2004 122 128 (Pubitemid 38133932)
108. M.S. Wicha, and D.F. Hayes Circulating tumor cells: not all detected cells are bad and not all bad cells are detected J Clin Oncol 29 2011 1508 1511
109. L. Xia, W. Huang, D. Tian, H. Zhu, X. Qi, and Z. Chen et al. Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma Hepatology 57 2013 610 624
110. L. Yang, J.C. Lang, P. Balasubramanian, K.R. Jatana, D. Schuller, and A. Agrawal et al. Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cells Biotechnol Bioeng 102 2009 521 534
111. D.R. Yates, M. Rouprêt, S.J. Drouin, E. Comperat, S. Ricci, and R. Lacave et al. Quantitative RT-PCR analysis of PSA and prostate-specific membrane antigen mRNA to detect circulating tumor cells improves recurrence-free survival nomogram prediction after radical prostatectomy Prostate 72 2012 1382 1388
112. Y. Ye, H. Tian, A.R. Lange, K. Yearsley, F.M. Robertson, and S.H. Barsky The genesis and unique properties of the lymphovascular tumor embolus are because of calpain-regulated proteolysis of E-cadherin Oncogene 32 2012 1702 1713
113. T. Yokobori, H. Iinuma, T. Shimamura, S. Imoto, K. Sugimachi, and H. Ishii et al. Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis Cancer Res 73 2013 2059 2069
114. M. Yu, A. Bardia, B.S. Wittner, S.L. Stott, M.E. Smas, and D.T. Ting et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition Science 339 2013 580 584
115. X. Yu, Y. Lin, X. Yan, Q. Tian, L. Li, and E.H. Lin CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality? Curr Colorectal Cancer Rep 7 2011 253 259
116. Z. Zhang, L. Han, L. Cao, X. Liang, Y. Liu, and H. Liu et al. Aggregation formation mediated anoikis resistance of BEL7402 hepatoma cells Folia Histochem Cytobiol 46 2008 331 336
117. S. Zhang, C.C. Wu, J.F. Fecteau, B. Cui, L. Chen, and L. Zhang et al. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 Proc Natl Acad Sci U S A 110 2013 6127 6132
118. S. Zheng, H. Lin, J.Q. Liu, M. Balic, R. Datar, and R.J. Cote et al. Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells J Chromatogr A 1162 2007 154 161 (Pubitemid 47187403)
119. S. Zheng, H.K. Lin, B. Lu, A. Williams, R. Datar, and R.J. Cote et al. 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood Biomed Microdevices 13 2011 203 213
120. R.E. Zigeuner, R. Riesenberg, H. Pohla, A. Hofstetter, and R. Oberneder Immunomagentic cell enrichment detects more disseminated cancer cells than immunocytochemistry in vitro J Urol 164 2000 1834 1837