The genesis and unique properties of the lymphovascular tumor embolus are because of calpain-regulated proteolysis of E-cadherin

Oncogene

Volumn 32, Issue 13, 2013, Pages 1702-1713

  Ye, Y ^a   Tian, H ^a   Lange, A R ^a   Yearsley, K ^b   Robertson, F M ^c   Barsky, S H ^a,d,e  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d Whittemore Peterson Institute   (United States)

^e NEVADA CANCER INSTITUTE   (United States)

Author keywords

Calpain mediated proteolysis; E cadherin fragments; Lymphovascular emboli; Spheroidgenesis

Indexed keywords

BETA CATENIN; CALCIUM ION; CALPAIN; CALPAIN 1; CALPAIN 2; CALPEPTIN; CASPASE 3; GAMMA SECRETASE; MATRIX METALLOPROTEINASE; PODOPLANIN; PROTEIN ANTIBODY; TRANSCRIPTOME; UVOMORULIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; BLASTOCYST; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL JUNCTION; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INFLAMMATORY BREAST CANCER; LYMPHATIC SYSTEM DISEASE; LYMPHOVASCULAR TUMOR EMBOLISM; METASTASIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; TUMOR CELL; TUMOR EMBOLISM; TUMOR SPHEROID; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOOD VESSELS; CADHERINS; CALPAIN; CARCINOMA; CELL ADHESION; CELL LINE, TUMOR; CELL SURVIVAL; EMBOLISM; FEMALE; HUMANS; INFLAMMATORY BREAST NEOPLASMS; LYMPHATIC VESSELS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEOLYSIS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84875906505     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.180     Document Type: Article

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