Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt

Tumor Biology

Volumn 35, Issue 3, 2014, Pages 1819-1825

  Du, Lei ^a   Mei, Hai Feng ^a   Yin, Xue ^a   Xing, Yi Qiao ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Aster tataricus; Bax Bcl 2; Caspase; Glioma; Polysaccharide

Indexed keywords

ANTINEOPLASTIC AGENT; ARABINOSE; ASTER TATARICUS POLYSACCHARIDE; CASPASE 3; CASPASE 8; CASPASE 9; GALACTOSE; GLUCOSE; MANNOSE; MONOSACCHARIDE; POLYSACCHARIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RHAMNOSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; ASTER TATARICUS; CANCER INHIBITION; CANCER TRANSPLANTATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; ENZYME ACTIVATION; GLIOMA; GLIOMA CELL; IN VITRO STUDY; IN VIVO STUDY; ION EXCHANGE; MALE; MEDICINAL PLANT; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SOLVENT EXTRACTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASTER PLANT; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ENZYME ACTIVATION; GLIOMA; IN SITU NICK-END LABELING; MALE; MOLECULAR WEIGHT; PHYTOTHERAPY; PLANT EXTRACTS; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84898904941     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1243-8     Document Type: Article

References (41)

1. Ohgaki H, Kleihues P. Epidemiology and etiology of gliomas. Acta Neuropathol. 2005;109:93-108.
2. Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors. Neurol Clin. 2007;25:867-90.
3. Merchant TE, Pollack IF, Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol. 2010;20:58-66.
4. Parajuli P, Mathupala S, Mittal S, Sloan AE. Dendritic cell-based active specific immunotherapy for malignant glioma. Expert Opin Biol Ther. 2007;7:439-48.
5. Lu DY, Chang CS, Yeh WL, Tang CH, Cheung CW, Leung YM, et al. The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways. Phytomedicine. 2012;19:1093-100.
6. Fresco P, Borges F, Diniz C, Marques MP. New insights on the anticancer properties of dietary polyphenols. Med Res Rev. 2006;26:747-66.
7. Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: promising anticancer agents. Med Res Rev. 2003;23:519-34.
8. Chen H, Ju Y, Li J, Yu M. Antioxidant activities of polysaccharides from Lentinus edodes and their significance for disease prevention. Int J Biol Macromol. 2012;50:214-8.
9. Li C, Cai J, Geng J, Li Y, Wang Z, Li R. Purification, characterization and anticancer activity of a polysaccharide from Panax ginseng. Int J Biol Macromol. 2012;51:968-73.
10. Xin T, Zhang F, Jiang Q, Chen C, Huang D, Li Y, et al. The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro. Int J Biol Macromol. 2012;51:788-93.
11. Cui B, Chen Y, Liu S, Wang J, Li S, Wang Q, et al. Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats. Int J Biol Macromol. 2012;51:314-8.
12. Cui J, Chisti Y. Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production. Biotechnol Adv. 2003;21:109-22.
13. Zhang M, Cui SW, Cheng PCK, Wang Q. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trends Food Sci Technol. 2007;18:4-19.
14. Lan MB, Guo J, Zhao HL, Yuan HH. Antioxidant and anti-tumor activities of purified polysaccharides with low molecular weights from Magnolia officinalis. J Med Plant Res. 2012;6:1025-34.
15. Ye CL, Hu WL, Dai DH. Extraction of polysaccharides and the antioxidant activity from the seeds of Plantago asiatica L. Int J Biol Macromol. 2011;49:466-70.
16. Miao S, Mao X, Pei R, Miao S, Xiang C, Lv Y, et al. Antitumor activity of polysaccharides from Lepista sordida against laryngocarcinoma in vitro and in vivo. Int J Biol Macromol. 2013;60:235-40.
17. Cai JP, Wu YJ, Li C, Feng MY, Shi QT, Li R, et al. Panax ginseng polysaccharide suppresses metastasis via modulating Twist expression in gastric cancer. Int J Biol Macromol. 2013;57:22-5.
18. Liu T, Ye L, Guan X, Liang X, Li C, Sun Q, et al. Immunopontentiating and antitumor activities of a polysaccharide from Pulsatilla chinensis (Bunge) Regel. Int J Biol Macromol. 2013;54:225-9.
19. Zeng G, Ju Y, Shen H, Zhou N, Huang L. Immunopontentiating activities of the purified polysaccharide from evening primrose in H22 tumor-bearing mice. Int J Biol Macromol. 2013;52:280-5.
20. Wu J, Zhou J, Lang Y, Yao L, Xu H, Shi H, et al. A polysaccharide from Armillaria mellea exhibits strong in vitro anticancer activity via apoptosis-involved mechanisms. Int J Biol Macromol. 2012;51:663-7.
21. Zhang Y, Wang Q, Wang T, Zhang H, Tian Y, Luo H, et al. Inhibition of human gastric carcinoma cell growth in vitro by a polysaccharide from Aster tataricus. Int J Biol Macromol. 2012;51:509-13.
22. Ye M, Liu JK, Lu ZX, Zhao Y, Liu SF, Li LL, et al. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett. 2005;579:3437-43.
23. Zhou WB, Tao YJ, Xu HM, Chen KL, Zeng GZ, Ji CJ, et al. Three new antiviral triterpenes from Aster tataricus. Z Naturforsch B J Chem Sci. 2010;65:1393-6.
24. Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, et al. New antitumour cyclic astin analogues: synthesis, conformation and bioactivity. J Pept Sci. 2004;10:92-102.
25. Ng TB, Liu F, Lu Y, Cheng CH, Wang Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp Biochem Physiol C Toxicol Pharmacol. 2003;136:109-15.
26. Staub AM. Removal of protein-Sevag method. Methods Carbohydr Chem. 1965;5:5-6.
27. Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. Colorimetric method for determination of sugars and related substances. Anal Chem. 1956;28:350-6.
28. Filisetti-Cozzi TMCC, Carpita NC. Measurement of uronic acids without interference from neutral sugars. Anal Biochem. 1991;197:157-62.
29. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein binding. Anal Biochem. 1976;72:248-54.
30. Du Z, Liu H, Zhang Z, Li P. Antioxidant and anti-inflammatory activities of Radix Isatidis polysaccharide in murine alveolar macrophages. Int J Biol Macromol. 2013;58:329-35.
31. Liu J, Zhang C, Wang Y, Yu H, Liu H, Wang L, et al. Structural elucidation of a heteroglycan from the fruiting bodies of Agaricus blazei Murill. Int J Biol Macromol. 2011;49:716-20.
32. Wu H, Guo H, Zhao R. Effect of Lycium barbarum polysaccharide on the improvement of antioxidant ability and DNA Damage in NIDDM rats. Yakugaku Zasshi. 2006;126:365-71.
33. Zhou F, Lv O, Zheng Y, Wang J, Hu P, Wang Z, et al. Inhibitory effect of Pulsatilla chinensis polysaccharides on glioma. Int J Biol Macromol. 2012;50:1322-6.
34. Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, et al. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005;33:726-37.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-75.
36. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Gene Dev. 1999;13:1899-911.
37. Petit PX, Susin SA, Zamzami N, Mignotte B, Kroemer G. Mitochondria and programmed cell death: back to the future. FEBS Lett. 1996;396:7-13.
38. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 1999;68:383-424.
39. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol. 1999;144:281-92.
40. Mullonkal CJ, Toledo-Pereyra LH. Akt in ischemia and reperfusion. J Invest Surg. 2007;20:195-203.
41. Fan Y, Sun C, Gao X, Wang F, Li X, Kassim RM, et al. Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways. Mol Med Rep. 2012;5:1185-90.