Structural modifications and tissue response after standard epi-off and iontophoretic corneal crosslinking with different irradiation procedures

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 4, 2014, Pages 2526-2533

  Mastropasqua, Leonardo ^a   Lanzini, Manuela ^a   Curcio, Claudia ^a   Calienno, Roberta ^a   Mastropasqua, Rodolfo ^b   Colasante, Martina ^a   Mastropasqua, Alessandra ^c   Nubile, Mario ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c Campus Biomedico   (Italy)

Author keywords

Crosslinking; Iontophoresis; Keratoconus

Indexed keywords

CD34 ANTIGEN; COLLAGEN TYPE 1; INTERSTITIAL COLLAGENASE;

APOPTOSIS; ARTICLE; CADAVER; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA STROMA; CORNEA THICKNESS; CROSS LINKING; DEFORMATION AMPLITUDE INDEX; DEFORMITY; EPI OFF TECHNIQUE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IONTOPHORESIS; PRIORITY JOURNAL; PROCEDURES; TISSUE INJURY; ULTRAVIOLET A RADIATION;

CROSSLINKING; IONTOPHORESIS; KERATOCONUS;

CADAVER; COLLAGEN; CORNEA; CROSS-LINKING REAGENTS; HUMANS; IMMUNOHISTOCHEMISTRY; IONTOPHORESIS; KERATOCONUS; ULTRAVIOLET RAYS;

EID: 84898878244     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13363     Document Type: Article

References (40)

1. Prasad R, Koul V. Transdermal delivery of methotrexate: past, present and future prospects. Ther Deliv. 2012;3:315-325.
2. Dubinsky RM, Kabbani H, El-Chami Z, Boutwell C, Ali H. Practice parameter: treatment of post-herpetic neuralgia: an evidence-based report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2004;63: 959-965.
3. Gomez I, Szabò A, Pap L, Boda K, Szekanecz Z. In vivo calcium and phosphate iontophoresis for the topical treatment of osteoporosis. Phys Ter. 2012;92:289-297.
4. Gaudana R, Ananthula HK, Parenky A, Mitra AK. Ocular drug delivery. AAPS J. 2010;12:348-360.
5. Frucht-Pery J, Raiskup F, Mechoulam H, Shapiro M, Eljarrat-Binstock M, Domb A. Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. Cornea. 2006;25:1182-1186.
6. Jiang J, Gill HS, Ghate D, et al. Coated microneedles for drug delivery to the eye. Invest Ophthalmol Vis Sci. 2007;48:4038-4043.
7. Yasukawa T, Ogura Y, Tabata Y, Kimura H, Wiedemann P, Honda Y. Drug delivery systems for vitreoretinal disease. Prog Retin Eye Res. 2004;23:253-281.
8. Vinciguerra P, Rechichi M, Rosetta P, et al. High fluence iontophoretic corneal collagen crosslinking: in vivo OCT imaging of riboflavin penetration. J Refract Surg. 2013;29: 376-377.
9. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet Ainduced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
10. Henriquez MA, Izquierdo L, Bernilla C, et al. Riboflavin/ ultraviolet A corneal collagen crosslinking for the treatment of keratoconus: visual outcomes and Scheimpflug analysis. Cornea. 2011;30;281-286.
11. Spoerl E, Huhle M, Seiler T. Induction of crosslinks in corneal tissue. Exp Eye Res. 1998;66:97-103.
12. Kohlhaas M, Spoerl E, Schilde T, et al. Biomechanical evidence of the distribution of crosslinks in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg. 2006;32:279-283.
13. Abdelghaffar W, Hantera M, Elsabagh H. Corneal collagen crosslinking: promises and problems. Br J Ophthalmol. 2010; 94:1559-1560.
14. Koller T, Iseli HP, Hafezi F, et al. Scheimpflug imaging of corneas after collagen crosslinking. Cornea. 2009;28:510-515.
15. Richoz O, Mavrakanas N, Pajic B, Hafezi F. Corneal collagen crosslinking for ectasia after LASIK and photorefractive keratectomy: long term results. Ophthalmology. 2013;120: 1354-1359.
16. Makdoumi K, Mortensen J, Crafoord S. Infectious keratitis treated with corneal crosslinking. Cornea. 2010;29:1353-1358.
17. Ghanem RC, Santhiago MR, Berti TB, Thomaz S, Netto MV. Collagen crosslinking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg. 2010;36:273-276.
18. Ehlers N, Hjortdal J, Nielsen K, et al. Riboflavin UVA treatment in the management of edema and non healing ulcers of the cornea. J Refract Surg. 2009;25:S803-S806.
19. Abdelghaffar W, Hantera M, Elsabagh H. Corneal collagen crosslinking: promises and problems. Br J Ophthalmol. 2010; 94:1559-1560.
20. Raiskup F, Spoerl E. Corneal crosslinking with riboflavin and ultraviolet A. I. Principles. Ocul Surf. 2013;11:65-74.
21. Mencucci R, Marini M, Paladini I, et al. Effects of riboflavin/ UVA corneal crosslinking on keratocytes and collagen fibres in human cornea. Clin Exp Ophthalmol. 2010;38:49-56.
22. Messmer EM, Meyer P, Herwig MC, et al. Morphological and immunohistochemical changes after corneal crosslinking. Cornea. 2013;32:111-117.
23. Hashemi H, Seyedian MA, Miraftab M, Fotouhi A, Asgari S. Corneal collagen crosslinking with riboflavin and ultraviolet a irradiation for keratoconus: long-term results. Ophthalmology. 2013;120:1515-1520.
24. Hon Y, Lam AK. Corneal deformation measurement using Scheimpflug noncontact tonometry. Optom Vis Sci. 2013;90: 1-8.
25. Seppälä HP, Määttä M, Rautia M, et al. EMMPRIN and MMP-1 in keratoconus. Cornea. 2006;25:325-330.
26. Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003;29:1786-1790.
27. Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A. Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg. 2009;35:893-899.
28. Ashwin PT, McDonnell PJ. Collagen crosslinkage: a comprehensive review and directions for future research. Br J Ophthalmol. 2010;94:965-970.
29. Filippello M, Stagni E, O'Brart D. Transepithelial corneal collagen crosslinking: bilateral study. J Cataract Refract Surg. 2012;38:283-291.
30. Salman AG. Transepithelial corneal collagen crosslinking for progressive keratoconus in a pediatric age group. J Cataract Refract Surg. 2013;39:1164-1170.
31. Nemeth G, Hassan Z, Csutak A, Szalai E, Berta A, Modis L Jr. Repeatability of ocular biomechanical data measurements with a Scheimpflug-based noncontact device on normal corneas. J Refract Surg. 2013;29:558-563.
32. Reznicek L, Muth D, Kampik A, Neubauer AS, Hirneiss C. Evaluation of a novel Scheimpflug-based non-contact tonometer in healthy subjects and patients with ocular hypertension and glaucoma. Br J Ophthalmol. 2013;97:1410-1414.
33. Kling S, Marcos S. Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests. Refract Surg. 2013;29:490-497.
34. Beshtawi IM, O'Donnell C, Radhakrishnan H. Biomechanical properties of corneal tissue after ultraviolet-A-riboflavin crosslinking. J Cataract Refract Surg. 2013;39:451-462.
35. Mastropasqua L, Nubile M, Lanzini M, et al. Morphological modification of the cornea after standard and transepithelial corneal crosslinking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy. Cornea. 2013;32:855-861.
36. Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen crosslinking using riboflavin/ UVA treatment. Cornea. 2004;23:43-49.
37. Dua HS, Joseph A, Shanmuganathan VA, Jones RE. Stem cell differentiation and the effects of deficiency. Eye (Lond). 2003; 17:877-885.
38. Joseph A, Hossain P, Jham S, et al. Expression of CD34 and Lselectin on human corneal keratocytes. Invest Ophthalmol Vis Sci. 2003;44:4689-4692.
39. Bikbova G, Bikbov M. Transepithelial corneal collagen crosslinking by iontophoresis of riboflavin. Acta Ophthalmol. 2014; 92:e30-e34.
40. Mastropasqua L, Nubile M, Calienno R, et al. Corneal crosslinking: Intrastromal riboflavin concentration in iontophoresisassisted imbibition versus traditional and transepithelial techniques. Am J Ophthalmol. 2014;157:623-630.