Riboflavin-UVA treatment in the management of edema and nonhealing ulcers of the cornea

Journal of Refractive Surgery

Volumn 25, Issue 9, 2009, Pages

  Ehlers, Niels ^a   Hjortdal, Jesper ^a   Nielsen, Kim ^a   Søndergaard, Anders ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOFLAVIN; SODIUM CHLORIDE;

ABRASION; ADULT; AGED; CLINICAL ARTICLE; CONFERENCE PAPER; CONGENITAL CORNEA DYSTROPHY; CONTROLLED STUDY; CORNEA EDEMA; CORNEA THICKNESS; CORNEA ULCER; CROSS LINKING; DRUG EFFECT; EYE INJURY; FEMALE; FOLLOW UP; GLAUCOMA; HUMAN; IRRADIATION; KERATOPATHY; MALE; POSTOPERATIVE CARE; PRIORITY JOURNAL; ULCER HEALING; ULTRAVIOLET A RADIATION; VISION;

AGED; AGED, 80 AND OVER; COLLAGEN; CORNEAL EDEMA; CORNEAL STROMA; CORNEAL ULCER; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RIBOFLAVIN; ULTRAVIOLET RAYS;

EID: 73249136705     PISSN: 1081597X     EISSN: None     Source Type: Journal    
DOI: 10.3928/1081597X-20090813-08     Document Type: Conference Paper

References (14)

1. Spörl E, Huhle M, Kasper M, Seiler T. Increased rigidity of the cornea caused by intrastromal cross-linking [German]. Ophthalmologe. 1997;94:902-906.
2. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
3. Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus. J Cataract Refract Surg. 2008;34:796-801.
4. Kumar V, Lockerbie O, Keil SD, Ruane PH, Platz MS, Martin CB, Ravanat J-L, Cadet J, Goodrich RP. Riboflavin and UV-light based pathogen reduction: extent and consequences of DNA damage at the molecular level. Photochem Photobiol. 2004;80:15-21.
5. Martins SA, Combs JC, Noguera G, Camacho W, Wittmann P, Walther R, Cano M, Dick J, Behrens A. Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. Invest Ophthalmol Vis Sci. 2008;49:3402-3408.
6. Ehlers N, Hjortdal J. Ribofl avin-ultraviolet light induced cross-linking in endothelial decompensation. Acta Ophthalmol. 2008;86:549-551.
7. Ytteborg J, Dohlman CH. Corneal edema and intraocular pressure. II. Clinical results. Arch Ophthalmol. 1965;74:477-484.
8. Hedbys BO, Dohlman CH. A new method for the determination of the swelling pressure of the corneal stroma in vitro. Exp Eye Res. 1963;2:122-129.
9. Olsen T, Sperling S. The swelling pressure of the human corneal stroma as determined by a new method. Exp Eye Res. 1987;44:481-490.
10. Schnitzler E, Spörl E, Seiler T. Irradiation of cornea with ultraviolet light and riboflavin administration as a new treatment for erosive corneal processes, preliminary results in four patients [German]. Klin Monatsbl Augenheilkd. 2000;217:190-193.
11. Ehlers N, Sperling S. A technical improvement of the Haag-Streit pachometer. Acta Ophthalmol. 1977;55:333-336.
12. Wollensak G, Aurich H, Wirbelauer C, Pham D-T. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res. 2009;41:114-117.
13. Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: laboratory investigation and first clinical case. J Refract Surg. 2008;24:S730-S736.
14. Spoerl E, Wollensak G, Seiler T. Increased resistance of cross-linked cornea against enzymatic digestion. Curr Eye Res. 2004;29:35-40.