In vivo calcium and phosphate iontophoresis for the topical treatment of osteoporosis

Physical Therapy

Volumn 92, Issue 2, 2012, Pages 289-297

  Gomez, Izabella ^a,b   Szabó, Andrea ^c   Pap, Lajos ^b,d   Boda, Krisztina ^e   Szekanecz, Zoltán ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d Höhere Technische Lehranstalt Technische Informatik   (Austria)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ESTRADIOL; PHOSPHATE;

ANIMAL; ARTICLE; BIOMECHANICS; BONE DENSITY; FEMALE; IONTOPHORESIS; METABOLIC BONE DISEASE; METHODOLOGY; OSTEOPOROSIS; OVARIECTOMY; RAT; SPRAGUE DAWLEY RAT; TIBIA;

ANIMALS; BIOMECHANICS; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; ESTRADIOL; FEMALE; IONTOPHORESIS; OSTEOPOROSIS; OVARIECTOMY; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 84856742322     PISSN: 00319023     EISSN: 15386724     Source Type: Journal    
DOI: 10.2522/ptj.20100400     Document Type: Article

References (25)

1. Zethraeus N, Borgstrom F, Strom O, et al. Cost-effectiveness of the treatment and prevention of osteoporosis: a review of the literature and a reference model. Osteoporos Int. 2007;18:9-23.
2. Poor G. Osteoporosis care in Hungary. Bull World Health Organ. 1999;77:429-430.
3. Kothawala P, Badamgarav E, Ryu S, et al. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007;82: 1493-1501.
4. Cauley JA, Seeley DG, Ensrud K, et al. Estrogen replacement therapy and fractures in older women: study of Osteoporotic Fractures Research Group. Ann Intern Med. 1995;122:9-16.
5. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA. 2002;288:321-333.
6. Pickar JH, Mirkin S. Tissue-selective agents: selective estrogen receptor modulators and the tissue-selective estrogen complex. Menopause Int. 2010;16:121-128.
7. Riesz E. Electro-calcium-stasis therapy of false ankylosis, retarded callus formation and Sudeck's atrophy [article in undetermined language]. Orv Hetil. 1952;93: 886-889.
8. Riesz E. Treatment of delayed callus formation, Sudeck's atrophy and pseudarthrosis with calcium-electrostasis. Ther Hung. 1953;4:15-21.
9. Riesz E. Pseudoarthrosis, prolonged, bad callus formation: therapy of Sudeck's atrophy by calcium electrostasis [article in Hungarian]. Orv Hetil. 1956;97:600-604.
10. Pap L, Gomez I, Pap L Jr, et al. Development of natural calcium- and phosphatedonating microparticles and a new iontophoretic apparatus for the topical treatment of local osteoporosis: preliminary in vitro and in vivo studies. Joint Bone Spine. 2010;77:426-431.
11. Varava GN, Podorozhnaia RP, Genesina TI, Sukmanskii VB. The effect of magnesium sulfate electrophoresis and galvanization on the mineralization of teeth and bones [article in Russian]. Stomatologiia (Mosk). 1990;69:12-14.
12. Antonic M, Kokanovic R, Vujicic M, Dokovic V. Effect of iontophoresis using calcium, phosphorus, galvanic current and vitamin D on the speed of bone-defect healing in a dog [article in Croatian]. Zb Vojnomed Akad. 1975:29-32.
13. Suzuki Y, Nagase Y, Iga K, et al. Prevention of bone loss in ovariectomized rats by pulsatile transdermal iontophoretic administration of human PTH(1-34). J Pharm Sci.2002;91:350-361.
14. Nakamura K, Katagai K, Mori K, et al. Transdermal administration of salmon calcitonin by pulse depolarizationiontophoresis in rats. Int J Pharm. 2001; 218:93-102.
15. Kalu DN, Liu CC, Salerno E, et al. Skeletal response of ovariectomized rats to low and high doses of 17 beta-estradiol. Bone Miner. 1991;14:175-187.
16. Canpolat S, Tug N, Seyran AD, et al. Effects of raloxifene and estradiol on bone turnover parameters in intact and ovariectomized rats. J Physiol Biochem. 2010;66: 23-28.
17. National Research Council. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC: The National Academies Press; 2011.
18. Szanto Z, Papp L, Konya J, et al. In vivo iontoforetic delivery of calcium ions. J Radioanal Nucl. 1999;241:45-49.
19. Joly J, Westhovens R, Borghs H, et al. Reference curve and diagnostic sensitivity for a new ultrasound device for the phalanges [correction of phalanages], the DBMsonic 1200, in Belgian women. Osteoporos Int. 1999;9:284-289.
20. Barkmann R, Kantorovich E, Singal C, et al. A new method for quantitative ultrasound measurements at multiple skeletal sites: first results of precision and fracture discrimination. J Clin Densitom. 2000;3:1-7.
21. Sims NA, Morris HA, Moore RJ, Durbridge TC. Estradiol treatment transiently increases trabecular bone volume in ovariectomized rats. Bone. 1996;19:455-461.
22. Pal S, Saha S. Effect of deformation rate on the flexural fracture behaviour of long bones. Med Biol Eng Comput. 1984;22: 251-254.
23. Sturmer EK, Seidlova-Wuttke D, Sehmisch S, et al. Standardized bending and breaking test for the normal and osteoporotic metaphyseal tibias of the rat: effect of estradiol, testosterone, and raloxifene. J Bone Miner Res. 2006;21:89-96.
24. Ortoft G, Oxlund H. Reduced strength of rat cortical bone after glucocorticoid treatment. Calcif Tissue Int. 1988;43:376-382.
25. Murphy J, Riley JP. A modified single solution method for the determination of phosphate in natural waters. Anal Chim Acta. 1962;7:31-36.