메뉴 건너뛰기




Volumn 93, Issue , 2014, Pages 37-47

Inactivation of PI3K/Akt pathway and upregulation of PTEN gene are involved in daucosterol, isolated from Salvia sahendica, induced apoptosis in human breast adenocarcinoma cells

Author keywords

Apoptosis; Daucosterol; PI3K AKT signaling; PTEN; Salvia sahendica

Indexed keywords

APOPTOSIS; BIOTECHNOLOGY; CANCER; CONCENTRATION (COMPOSITION); DICOTYLEDON; DISEASE TREATMENT; ENZYME ACTIVITY; ETHNOBOTANY; GENE EXPRESSION; INHIBITION; MEDICINAL PLANT; MORPHOLOGY; PLANT EXTRACT; STEROL; TUMOR;

EID: 84898850675     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2014.03.010     Document Type: Article
Times cited : (31)

References (48)
  • 2
    • 1842335728 scopus 로고    scopus 로고
    • Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa
    • Awad A.B., Hernandez A.Y.T., Fink C.S., Mendel S.L. Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa. Nutrition and Cancer 1997, 27:210-215.
    • (1997) Nutrition and Cancer , vol.27 , pp. 210-215
    • Awad, A.B.1    Hernandez, A.Y.T.2    Fink, C.S.3    Mendel, S.L.4
  • 3
    • 0035728953 scopus 로고    scopus 로고
    • Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells
    • Awad A.B., Williams H., Fink C.S. Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutrition and Cancer 2001, 40:157-164.
    • (2001) Nutrition and Cancer , vol.40 , pp. 157-164
    • Awad, A.B.1    Williams, H.2    Fink, C.S.3
  • 4
    • 0042839732 scopus 로고    scopus 로고
    • Cytotoxic activity of some lichen extracts on murine and human cancer cell lines
    • Bézivin C., Tomasi S., Lohezic-Le Devehat F., Boustie J. Cytotoxic activity of some lichen extracts on murine and human cancer cell lines. Phytomedicine 2003, 10:499-503.
    • (2003) Phytomedicine , vol.10 , pp. 499-503
    • Bézivin, C.1    Tomasi, S.2    Lohezic-Le Devehat, F.3    Boustie, J.4
  • 5
    • 0030433856 scopus 로고    scopus 로고
    • Beta-sitosterol and beta-sitosterol gylcoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination
    • Boulic P.J.D., Etsebeth S., Liebenberg R.W. Beta-sitosterol and beta-sitosterol gylcoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination. International Journal of Immunopharmacology 1996, 18:693-700.
    • (1996) International Journal of Immunopharmacology , vol.18 , pp. 693-700
    • Boulic, P.J.D.1    Etsebeth, S.2    Liebenberg, R.W.3
  • 7
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: Akt ion on multiple fronts
    • Brazil D.P., Yang Z.Z., Hemmings B.A. Advances in protein kinase B signalling: Akt ion on multiple fronts. Trends in Biochemical Sciences 2004, 29:233-242.
    • (2004) Trends in Biochemical Sciences , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 9
    • 0035921762 scopus 로고    scopus 로고
    • Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer
    • Chen X., Thakkar H., Tyan F., Gim S., Robinson H., Lee C. Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. Oncogene 2001, 20:6073-6083.
    • (2001) Oncogene , vol.20 , pp. 6073-6083
    • Chen, X.1    Thakkar, H.2    Tyan, F.3    Gim, S.4    Robinson, H.5    Lee, C.6
  • 10
    • 33645865550 scopus 로고    scopus 로고
    • A causal relationship discovery based approach to identifying active components of herbal medicine
    • Cheng Y., Wang Y., Wang X.W. A causal relationship discovery based approach to identifying active components of herbal medicine. Computational Biology and Chemistry 2006, 30:146-154.
    • (2006) Computational Biology and Chemistry , vol.30 , pp. 146-154
    • Cheng, Y.1    Wang, Y.2    Wang, X.W.3
  • 11
    • 33745950626 scopus 로고    scopus 로고
    • Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
    • Chipuk J.E., Bouchier-Hayes L., Green D.R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death and Differentiation 2006, 13:1396-1402.
    • (2006) Cell Death and Differentiation , vol.13 , pp. 1396-1402
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Green, D.R.3
  • 15
    • 84883742380 scopus 로고    scopus 로고
    • Dietary supplementation with Salvia sahendica attenuates acetylcholinesterase activity and increases mitochondrial transcription factor A and antioxidant proteins in the hippocampus of amyloid beta-injected rats
    • Foolad F., Khodagholi F. Dietary supplementation with Salvia sahendica attenuates acetylcholinesterase activity and increases mitochondrial transcription factor A and antioxidant proteins in the hippocampus of amyloid beta-injected rats. Journal of Pharmacy and Pharmacology 2013, 65:1555-1562.
    • (2013) Journal of Pharmacy and Pharmacology , vol.65 , pp. 1555-1562
    • Foolad, F.1    Khodagholi, F.2
  • 17
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/Akt - a major therapeutic target
    • Hanada M., Feng J., Hemmings B.A. Structure, regulation and function of PKB/Akt - a major therapeutic target. Biochemical Biophysical Acta 2004, 1697:3-16.
    • (2004) Biochemical Biophysical Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 18
    • 0026754691 scopus 로고
    • Dose-dependent effects of dietary phytosterols on epithelial cell proliferation of the murine colon
    • Janezic S.A., Rao A.V. Dose-dependent effects of dietary phytosterols on epithelial cell proliferation of the murine colon. Food and Chemical Toxicology 1992, 30:611-616.
    • (1992) Food and Chemical Toxicology , vol.30 , pp. 611-616
    • Janezic, S.A.1    Rao, A.V.2
  • 20
    • 2442574038 scopus 로고    scopus 로고
    • β-Sitosterol, β-sitosterol glucoside, and a mixture of β-sitosterol and β-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic
    • Ju Y.H., Clausen L.M., AllredK F., Almada A.L., Helferich W.G. β-Sitosterol, β-sitosterol glucoside, and a mixture of β-sitosterol and β-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic. Journal of Nutrition 2004, 134:1145-1151.
    • (2004) Journal of Nutrition , vol.134 , pp. 1145-1151
    • Ju, Y.H.1    Clausen, L.M.2    AllredK, F.3    Almada, A.L.4    Helferich, W.G.5
  • 21
    • 84871830226 scopus 로고    scopus 로고
    • Dietary supplementation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid beta-injected rats
    • Khodagholi K., Ashabi G. Dietary supplementation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid beta-injected rats. Behavioural Brain Research 2013, 15:62-69.
    • (2013) Behavioural Brain Research , vol.15 , pp. 62-69
    • Khodagholi, K.1    Ashabi, G.2
  • 22
    • 1542395634 scopus 로고    scopus 로고
    • Hydroxylation at C40 or C6 is essential for apoptosisinducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species
    • Ko C.H., Shen S.C., Chen Y.C. Hydroxylation at C40 or C6 is essential for apoptosisinducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species. Free Radical Biology and Medicine 2004, 36:897-910.
    • (2004) Free Radical Biology and Medicine , vol.36 , pp. 897-910
    • Ko, C.H.1    Shen, S.C.2    Chen, Y.C.3
  • 23
    • 34247177491 scopus 로고    scopus 로고
    • Immunoregulatory activity by daucosterol, a β-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice
    • Lee J.H., Lee L.Y., Park J.H., Jung H.S., Kimb J.S., Kangb S.S. Immunoregulatory activity by daucosterol, a β-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice. Vaccine 2007, 25:3834-3840.
    • (2007) Vaccine , vol.25 , pp. 3834-3840
    • Lee, J.H.1    Lee, L.Y.2    Park, J.H.3    Jung, H.S.4    Kimb, J.S.5    Kangb, S.S.6
  • 25
    • 33644851854 scopus 로고    scopus 로고
    • Cadmiuminduces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture
    • Lopez E., Arce C., Oset-Gasque M.J., Canadas S., Gonzalez M.P. Cadmiuminduces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radical Biology and Medicine 2006, 40:940-995.
    • (2006) Free Radical Biology and Medicine , vol.40 , pp. 940-995
    • Lopez, E.1    Arce, C.2    Oset-Gasque, M.J.3    Canadas, S.4    Gonzalez, M.P.5
  • 26
    • 78649287785 scopus 로고    scopus 로고
    • Evaluation of the antibacterial activity of Salvia sahendica and Phlomis caucasica
    • (Tabriz University of Medical Sciences)
    • Lotfipour F., Samiee M., Nazemiyeh H. Evaluation of the antibacterial activity of Salvia sahendica and Phlomis caucasica. Pharmaceutical sciences, Journal of Faculty of Pharmacy 2007, 1:29-34. (Tabriz University of Medical Sciences).
    • (2007) Pharmaceutical sciences, Journal of Faculty of Pharmacy , vol.1 , pp. 29-34
    • Lotfipour, F.1    Samiee, M.2    Nazemiyeh, H.3
  • 27
    • 2142853088 scopus 로고    scopus 로고
    • Detection of mitochondrial localization of p53
    • Mihara M., Moll U.M. Detection of mitochondrial localization of p53. Methods in Molecular Biology 2003, 234:203-209.
    • (2003) Methods in Molecular Biology , vol.234 , pp. 203-209
    • Mihara, M.1    Moll, U.M.2
  • 30
    • 42749090904 scopus 로고    scopus 로고
    • β-Sitosterol induces G2/M arrest endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways
    • Moon D.O., Kim M.O., Choi Y.H., Kim G.Y. β-Sitosterol induces G2/M arrest endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Cancer Letters 2008, 264:181-191.
    • (2008) Cancer Letters , vol.264 , pp. 181-191
    • Moon, D.O.1    Kim, M.O.2    Choi, Y.H.3    Kim, G.Y.4
  • 33
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunology Methods 1991, 139:271-279.
    • (1991) Journal of Immunology Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 34
    • 0034672108 scopus 로고    scopus 로고
    • Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2
    • Osseni R.A., Rat P., Bogdan A., Warnet J.M., Touitou Y. Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2. Life Sciences 2000, 68:387-399.
    • (2000) Life Sciences , vol.68 , pp. 387-399
    • Osseni, R.A.1    Rat, P.2    Bogdan, A.3    Warnet, J.M.4    Touitou, Y.5
  • 35
    • 50649123243 scopus 로고    scopus 로고
    • Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity
    • Paniagua-Pérez R., Madrigal-Bujaidar E., Reyes-Cadena S. Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. Achieves of Toxicology 2008, 82:615-622.
    • (2008) Achieves of Toxicology , vol.82 , pp. 615-622
    • Paniagua-Pérez, R.1    Madrigal-Bujaidar, E.2    Reyes-Cadena, S.3
  • 36
    • 0032977906 scopus 로고    scopus 로고
    • Plant sterols and sterolin: a review of their immunemodulating properties
    • Patrick J.D., Lamprecht J.H. Plant sterols and sterolin: a review of their immunemodulating properties. Alternative Medicine Review 1999, 4:170-177.
    • (1999) Alternative Medicine Review , vol.4 , pp. 170-177
    • Patrick, J.D.1    Lamprecht, J.H.2
  • 37
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano H., Carney D., Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 2004, 7:97-110.
    • (2004) Drug Resistance Updates , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 38
    • 0018872473 scopus 로고
    • Protective effect of plant sterols against chemically induced colon tumors in rats
    • Raicht R.F., Cohen B.I., Fazzini E.P., Sarwal A.N., Takahashi M. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Research 1980, 40:403-405.
    • (1980) Cancer Research , vol.40 , pp. 403-405
    • Raicht, R.F.1    Cohen, B.I.2    Fazzini, E.P.3    Sarwal, A.N.4    Takahashi, M.5
  • 40
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri B.A., Huang L., Wood M., Cheng J.Q., Testa J.R. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Molecular Carcinogenesis 1998, 21:81-86.
    • (1998) Molecular Carcinogenesis , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 41
    • 34548441231 scopus 로고    scopus 로고
    • Antibacterial and antioxidant activities of the essential oils and various extracts of Salvia sahendica in different henological stages
    • Salehi P., Sonboli A., Ebrahimi S.N., Yousefzadi M. Antibacterial and antioxidant activities of the essential oils and various extracts of Salvia sahendica in different henological stages. Chemistry of Natural Compounds 2007, 43:328-330.
    • (2007) Chemistry of Natural Compounds , vol.43 , pp. 328-330
    • Salehi, P.1    Sonboli, A.2    Ebrahimi, S.N.3    Yousefzadi, M.4
  • 42
    • 33947125330 scopus 로고
    • Prunasin, daucosterin and sitosterol from the bitter seeds of Prunus amygdalus
    • Schwarzmaier U. Prunasin, daucosterin and sitosterol from the bitter seeds of Prunus amygdalus. Phytochemistry 1972, 11:2358-2360.
    • (1972) Phytochemistry , vol.11 , pp. 2358-2360
    • Schwarzmaier, U.1
  • 43
    • 79960447260 scopus 로고    scopus 로고
    • Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells
    • Shaerzadeh F., Ahmadiani A., Esmaeili M.A., Ansari N., Asadi S., Tusi S.K. Antioxidant and antiglycating activities of Salvia sahendica and its protective effect against oxidative stress in neuron-like PC12 cells. Journal of Natural Medicines 2011, 65:455-465.
    • (2011) Journal of Natural Medicines , vol.65 , pp. 455-465
    • Shaerzadeh, F.1    Ahmadiani, A.2    Esmaeili, M.A.3    Ansari, N.4    Asadi, S.5    Tusi, S.K.6
  • 44
    • 80755139521 scopus 로고    scopus 로고
    • Neuroprotective effect of Salvia sahendica is mediated by restoration of mitochondrial function and inhibition of endoplasmic reticulum stress
    • Shaerzadeh F., Alamdary S.Z., Esmaeili M.A., Sarvestani N.N., Khodagholi F. Neuroprotective effect of Salvia sahendica is mediated by restoration of mitochondrial function and inhibition of endoplasmic reticulum stress. Neurochemistry Research 2011, 36:2216-2226.
    • (2011) Neurochemistry Research , vol.36 , pp. 2216-2226
    • Shaerzadeh, F.1    Alamdary, S.Z.2    Esmaeili, M.A.3    Sarvestani, N.N.4    Khodagholi, F.5
  • 45
    • 0033519705 scopus 로고    scopus 로고
    • Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
    • Shimizu S., Narita M., Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999, 3:483-487.
    • (1999) Nature , vol.3 , pp. 483-487
    • Shimizu, S.1    Narita, M.2    Tsujimoto, Y.3
  • 48
    • 33744989211 scopus 로고    scopus 로고
    • Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase
    • Xiong Y., Liu X., Lee C.P., Chua B.H., Ho Y.S. Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase. Free Radical Biology and Medicine 2006, 41:46-55.
    • (2006) Free Radical Biology and Medicine , vol.41 , pp. 46-55
    • Xiong, Y.1    Liu, X.2    Lee, C.P.3    Chua, B.H.4    Ho, Y.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.