Cell protection induced by beta-sitosterol: Inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity

Archives of Toxicology

Volumn 82, Issue 9, 2008, Pages 615-622

  Paniagua Perez R ^a   Madrigal Bujaidar, E ^b   Reyes Cadena, S ^a   Alvarez Gonzalez I ^b   Sanchez Chapul L ^a   Perez Gallaga J ^a   Hernandez N ^a   Flores Mondragon G ^a   Velasco, O ^a  

^a INSTITUTO NACIONAL DE REHABILITACIÓN   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Antigenotoxicity; Antioxidant; Beta sitosterol; Doxorubicin

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; DOXORUBICIN; FREE RADICAL; HLA ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; SITOSTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW CELL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ERYTHROCYTE; GENOTOXICITY; IN VITRO STUDY; LYMPHOCYTOPOIESIS; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; TREATMENT OUTCOME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; CELL PROLIFERATION; DOXORUBICIN; FREE RADICAL SCAVENGERS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MICE; MICRONUCLEUS TESTS; PROTECTIVE AGENTS; SISTER CHROMATID EXCHANGE; SITOSTEROLS;

MUS;

EID: 50649123243     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0277-3     Document Type: Article

References (50)

1. JL Aguilar P Rojas A Marcelo A Plaza R Bauer E Reininger CA Klaas I Merfort 2002 Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae) J Ethnopharmacol 81 271 276
2. M Antolovich PD Prenzler E Patsalides S McDonald K Robards 2002 Methods for testing antioxidant activity Analyst 127 183 198
3. AB Awad CS Fink 2000 Phytosterols as anticancer dietary components: evidence and mechanism of action J Nutr 130 2127 2130
4. AB Awad RL von Holtz JP Cone CS Fink YC Chen 1998 beta-Sitosterol inhibits the growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle Anticancer Res 18 471 479
5. RR Berges J Windeler HJ Trampisch T Senge 1995 Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group Lancet 345 1529 1532
6. RR Berges A Kassen T Senge 2000 Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up BJU Int 85 842 846
7. PJ Bouic 2001 The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years Curr Opin Clin Nutr Metab Care 4 471 475
8. PJ Bouic S Etsebeth RW Leibenberg CF Albrecht K Pegel PP Van Jaarsveld 1996 beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination Int J Immunopharmacol 18 693 700
9. PJ Bouic A Clark J Lamprecht M Freestone EJ Pool RW Liebenberg D Kotze PP van Jaarsveld 1999 The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation Int J Sports Med 20 258 262
10. U Breytenbach A Clark J Lamprecht P Bouic 2001 Flow cytometric analysis of the Th1-Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus (HIV) receiving a plant sterol/sterolin mixture Cell Biol Int 25 43 49
11. HC Chen 2001 Molecular mechanisms of sterol absorption J Nutr 131 2603 2605
12. RH Delaporte MH Sarragiotto OS Takemura GM Sanchez BP Filho CV Nakamura 2004 Evaluation of antioedematogenic free radical scavenging and antimicrobial activities of aerial parts of Tillandisiastreptocarpa Baker-Bromeliaceae J Ethnopharmacol 95 229 233
13. S Gorinstein O Martin-Belloso E Katrich A Lojek M Cìz N Gligelmo-Miguel R Harnenkit YS Park ST Jung S Trakhtenberg 2003 Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging test J Nutr Biochem 14 154 159
14. MB Gupta R Nath N Srivastava K Shanker K Kishor KP Bhargava 1980 Anti-inflammatory and antipyretic activities of beta-sitosterol Planta Med 39 157 163
15. C Han H Ding B Casto GD Stoner SM D'Ambrosio 2005 Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries Nutr Cancer 51 207 217
16. P Haydn Pritchard M Li C Zamfir T Lukic E Novak MH Moghadasian 2003 Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol™) tall oil-derived phytosterols in apo E-deficient mice Cardiovasc Drugs Ther 17 443 449
17. HF Hendriks EJ Brink GW Meijer HM Princen FY Ntanios 2003 Safety of long-term consumption of plant sterol esters-enriched spread Eur J Clin Nutr 57 681 692
18. A Hernandez-Ceruelos E Madrigal-Bujaidar C de la Cruz 2004 Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow Toxicol Lett 135 103 110
19. GK Jayaprakasha KK Mandadi SM Poulose Y Jadegoud GA Nagana Gowda BS Patil 2007 Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf Bioorg Med Chem 15 4923 4932
20. YH Ju LM Claussen KF Allred AL Almada WG Helferich 2004 Beta-sistosterol, beta-sistoterol glucoside, and a mixture of beta-sitosterol and beta-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice J Nutr 134 1139 1144
21. A Kassen R Berges T Senge 2000 Effect of beta-sitosterol on transforming growth factor-beta-1 expression and translocation protein kinase C alpha in human prostate stromal cells in vitro Eur Urol 37 735 741
22. K Keplinger G Laus M Wurm MP Dierich H Teppner 1999 Uncaria tomentosa (Willd.) DC. - ethnomedicinal use and new pharmacological, toxicological and botanical results J Ethnopharmacol 64 23 34
23. MA Khan J Mustafa J Musarrat 2003 Mechanism of DNA strand breakage induced by photosensitized tetracycline-Cu(II) complex Mutat Res 525 109 119
24. KF Klippel DM Hiltl B Schipp 1997 A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group Br J Urol 80 427 432
25. N Kocak H Ustun MD Gulkac AO Kanli A Borazan A Yilmaz 2004 Effects of 10alpha,25-dihydroxyvitamin D3 on doxorubicin-induced chromosomal aberrations in rat bone marrow cells Acta Oncol 43 204 208
26. JC Lim JH Park M Budesinsky A Kasal YH Han BS Koo SI Lee DU Lee 2005 Antimutagenic constituents from the thorns of Gleditsia sinensis Chem Pharm Bull 53 561 564
27. WH Ling PJ Jones 1995 Dietary phytosterols: a review of metabolism, benefits and side effects Life Sci 57 195 206
28. E Madrigal-Santillán E Madrigal-Bujaidar R Marquez-Marquez A Reyes 2006 Antigenotoxic effect of Saccharomyces cereviciae on the damage produced in mice fed with aflatoxin B(1) contaminated corn Food Chem Toxicol 44 2058 2063
29. B Melichar M Tousková J Dvorák P Jandik O Kopecký 2001 The peripheral blood leukocyte phenotype in patients with breast cancer: effect of doxorubicin/paclitaxel combination chemotherapy Immunopharmacol Immunotoxicol 23 163 173
30. H Mizutani S Oikawa Y Hiraku M Murata M Kojima M Kawanishi 2003 Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper (II) and NADPH-cytochrome P450 reductase Cancer Sci 94 686 691
31. Z Ovesna A Vachalkova K Horvathova 2004 Taraxasterol and beta-sitosterol: new naturally compounds with chemoprotective/chemopreventive effects Neoplasma 51 407 414
32. R Paniagua-Perez E Madrigal-Bujaidar CS Reyes GJ Perez MO Velasco D Molina 2002 Sister chromatid exchanges produced by imipramine and desipramine in mouse bone marrow cells treated in vivo Toxicol Lett 132 123 129
33. R Paniagua-Perez E Madrigal-Bujaidar S Reyes-Cadena D Molina-Jasso JP Gallaga A Silva-Miranda O Velazco N Hernández G Chamorro 2005 Genotoxic and cytotoxic studies of Beta-sitosterol and pteropodine in mouse J Biomed Biotechnol 2005 242 247
34. KY Park KD Jung SH Rhee YH Choi 2003 Antimutagenic effects of doenjang (Koren fermented soypaste) and its active compounds Mutat Res 523-524 43 53
35. KI Pegel 1997 The importance of sitosterol and sitosterolin in human and animal nutrition S Afr J Sci 93 263 268
36. RF Raicht BI Cohen EP Fazzini AN Sarwal M Takahashi 1980 Protective effect of plant sterols against chemically induced colon tumors in rats Cancer Res 40 403 405
37. R Rizzi F Re A Bianchi V De Feo F de Simone L Bianchi LA Stivala 1993 Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts J Ethnopharmacol 38 63 77
38. M Romero-Jimenez J Campos-Sanchez M Analla A Muñoz-Serrano A Alonso-Moraga 2005 Genotoxicity and anti-genotoxicity of some traditional medicinal herbs Mutat Res 585 147 155
39. A Russo R Aquaviva A Campisi V Sorrenti C Di Giacomo G Virgata ML Barcellona A Vanilla 2000 Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors Cell Biol Toxicol 16 91 98
40. A Sarkar BK Saha R Basak I Mukhopadhyay R Karmakar M Chatterjee 2000 Anticlastogenic potential of 1alpha,25-dihydroxyvitamin D3 in murine lymphoma Cancer Lett 150 1 13
41. RD Snyder PJ Gillies 2002 Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells Environ Mol Mutagen 40 266 276
42. G Takemura H Fujiwara 2007 Doxorubicin-induced cardiomyophaty from the cardiotoxic mechanisms to management Prog Cardiovasc Dis 49 330 352
43. GR Takeoka LT Dao 2003 Antioxidant constituents of almond [Prunus dulcis (Mill.) D. A. Webb] hulls J Agric Food Chem 51 496 501
44. H Tapiero DM Townsend KD Tew 2003 Phytosterols in the prevention of human pathologies Biomed Pharmacother 57 321 325
45. IM Villaseñor P Lemon A Palileo JB Bremner 1996 Antigenotoxic spinasterol from Cucurbita maxima flowers Mutat Res 360 89 93
46. IM Villaseñor J Angelada AP Canlas D Echegoyen 2002 Bioactivity studies on beta-sitosterol and its glucoside Phytother Res 16 417 421
47. M Vivancos JJ Moreno 2005 beta-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages Free Radic Biol Med 39 91 97
48. RL von Holtz CS Fink AB Awad 1998 beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells Nutr Cancer 32 8 12
49. XY Zhang WG Li YJ Wu MT Gao 2005 Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice J Pharm Pharmacol 57 1043 1052
50. XY Zhang WG Li YJ Wu TZ Zehng W Li SY Qu NF Liu 2005 Protoanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism Int Immunopharmacol 5 1247 1257