Rapid identification of chemical constituents in traditional Chinese medicine Fufang preparation Xianling Gubao capsule by LC-linear ion trap/orbitrap mass spectrometry

American Journal of Chinese Medicine

Volumn 41, Issue 5, 2013, Pages 1181-1198

  Dai, Yi ^a   Tu, Feng Juan ^b   Yao, Zhi Hong ^a   Ding, Bo ^a   Xu, Wen ^c   Qiu, Xiao Hui ^c   Yao, Xin Sheng ^a,b  

^a JINAN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Flavonol Glycosides; HPLC MSn; Prenylated Flavonoids; TCM Fufang Preparation; Xianling Gubao

Indexed keywords

3' HYDROXYICARITIN; 4' METHOXYNORICARINTIN; AGLYCONE; ALKALOID; CHALCONE DERIVATIVE; CHLOROGENIC ACID; COUMARIN DERIVATIVE; FLAVONOID; FLAVONOID GLYCOSIDE; FLAVONONE; GLYCOSIDE; HERBACEOUS AGENT; ICARITIN; IRIDOID; ISOFLAVONE; KAEMPFEROL; LIGNAN; LOGANIN; NORANHYDROICARITIN; NORICARITIN; PHENETHYL ALCOHOL GLYCOSIDE; PHENOL DERIVATIVE; PHENOLIC ACID; QUERCETIN; SALIDROSIDE; SAPONIN; SUGAR; TANSHINONE; UNCLASSIFIED DRUG; XANTHONE C GLYCOSIDE; XIANLING GUBAO EXTRACT;

ARTICLE; CHINESE MEDICINE; DRUG IDENTIFICATION; DRUG SCREENING; ION TRAP MASS SPECTROMETRY; MASS SPECTROMETRY; ORBITRAP MASS SPECTROMETRY; QUALITY CONTROL;

CAPSULES; CARBOHYDRATE CONFORMATION; CARBOHYDRATES; CHALCONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVONES; FLAVONOIDS; FLAVONOLS; GLYCOSIDES; MASS SPECTROMETRY; PRENYLATION; QUALITY CONTROL; XANTHONES;

EID: 84885919290     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500808     Document Type: Article

References (18)

1. Ablajan, K., Z. Abliz, X.Y. Shang, J.M. He, R.P. Zhang and J.G. Shi. Structural characterization of flavonol 3,7-di-O-glycosides and determination of the glycosylation position by using negative ion electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 41: 352-360, 2006.
2. Clifford, M.N., K.L. Johnston, S. Knight and N. Kuhnert. Hierarchical scheme for LC-MSn identification of chlorogenic acids. J. Agric. Food Chem. 51: 2900-2911, 2003.
3. Ferreres, F., R. Llorach and A. Gil-lzquierdo. Characterization of the interglycosidic linkage in di-, tri-, tetra- and pentaglycosylated flavonoids and differentiation of positional isomers by liquid chromatography/electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 39: 312-321, 2004.
4. Gattuso, G., C. Caristi, C. Gargiulli, E. Bellocco, G. Toscano and U. Leuzzi. Flavonoid glycosides in Bergamot juice (Citrus bergamia Risso). J. Agric. Food Chem. 54: 3929-3935, 2006.
5. Hertog, M.G.L., P.C.H. Hollman and D.P. Venema. Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Food Chem. 40: 1591-1598, 1992.
6. Li, X., Y.F. Zhang, X. Zeng, L. Yang and Y.H. Deng. Chemical profiling of bioactive constituents in Sarcandra glabra and its preparations using ultra-high-pressure liquid chromatography coupled with LTQ Orbitrap mass spectrometry. Rapid Commun. Mass Spectrom. 25: 2439-2447, 2011.
7. Liu, A.H., H. Guo, M. Ye, Y.H. Lin, H.H. Sun, M. Xu and D.A. Guo. Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. J. Chromatogr. A. 1161: 170-182, 2007.
8. Oh, K.Y., J.H. Lee, M.J. Curtis-Long, J.K. Cho, J.Y. Kim, W.S. Lee and K.H. Park. Glycosidase inhibitory phenolic compounds from the seed of Psoralea corylifolia. Food Chem. 121: 940-945, 2010.
9. Qiao, S.Y., J.F. Guo, Y.M. Zhao and S. Zhang. Rapid discovery and analysis of C-glycosylflavones from Stellaria media (L) Cyr. by MS/MS. Chin. J. Nat. Med. 1: 120-123, 2003.
10. Rarch, R.E., X.S. Miao and C.D. Metcalfe. A fragmentation study of a flavone triglycoside, kaempferol-3-O-robinoside-7-O-rhamnoside. Rapid Commun. Mass Spectrom. 18: 931-934, 2004.
11. Simons, R., J.P. Vincken, M.C. Bohin, T.F.M. Kuijpers, M.A. Verbruggen and H. Gruppen. Identification of prenylated pterocarpans and other isoflavonoids in Rhizopus spp. elicited soya bean seedlings by electrospray ionisation mass spectrometry. Rapid Commun. Mass Spectrom. 25: 55-65, 2011.
12. Tu, F.J., Y. Dai, Z.H. Yao, X.L. Wang, X.S. Yao and L. Qin. Flavonol glycosides from Epimedium pubescens. Chem. Pharm. Bull. 59: 1317-1321, 2011.
13. Wang, K., Z.Y. Zhu, L. Yang, Y. Gao, W.Y. Liu, H. Zhang and Y.F. Chai. Detection, characterization and identification of major constituents in Zhimu-Baihe herb-pair extract by fast highperformance liquid chromatography and time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage. Rapid Commun. Mass Spectrom. 25: 9-19, 2011.
14. Wang, X.L., G. Zhang, Y.X. He, L.Z. Zheng, F.J. Tu, X.S. Yao and L. Qin. XLGB-B prevents bone loss in OVX mice by inhibiting bone remodeling. Bone 47: S433-S433, 2010.
15. Wang, Y., L.L. Zhou and R. Li. The study progress in Dipsacus asper Wall. Lishizhen Med. Mater. Med. Res. 13: 233-234, 2002.
16. Yin, S., C.Q. Fan, Y. Wang, L. Dong and H.M. Yue. Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-Activity relationship study. Bioorgan. Med. Chem. 12: 4387-4392, 2004.
17. Zhao, H.Y., J.H. Sun, M.X. Fan, L. Fan, L. Zhou, Z. Li, J. Han, B.R. Wang and D.A. Guo. Analysis of phenolic compounds in Epimedium plants using liquid chromatography coupled with electrospray ionization mass spectrometry. J. Chromatogr. A 1190: 157-181, 2008.
18. Zhu, H.M., L. Qin, P. Garnero, H.K. Genant, G. Zhang, K.R. Dai, X.S. Yao, G.S. Gu, Y.Q. Hao, Z.S. Li, Y.L. Zhao, W.L. Li, J.W. Yang, X. Zhao, D.P. Shi, T. Fuerst, Y. Lu, H.L. Li, X.L. Zhang, C.S. Li, J.X. Zhao, Q.L. Wu and S.J. Zhao. The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis. Bone 47: S457-S458, 2010.